Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

Current protocols in molecular biology

1988 • 7,584 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction

2013 • 1,306 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1989 • 972 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

Immune interferon: a pleiotropic lymphokine with multiple effects

1985 • 676 citations

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

1989 • 667 citations

Structure of the human immune interferon gene

1982 • 510 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

1991 • 423 citations

Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.

1990 • 422 citations

Estrogen regulates the IFN-gamma promoter.

1991 • 409 citations

Genomic Sequencing and Methylation Analysis by Ligation Mediated PCR

1989 • 408 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

Diversity of Cytokine Synthesis and Function of Mouse CD4⁺ T Cells

1991 • 371 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.

1991 • 316 citations

Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.

1990 • 292 citations

A sensitive method for the detection of beta-galactosidase in transfected mammalian cells.

1991 • 283 citations

Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells.

1991 • 261 citations

Analysis of the AP-1 sites in the IL-2 promoter.

1992 • 179 citations

A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.

1991 • 178 citations

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.

1987 • 174 citations

Negative regulation of interleukin 2 transcription by the glucocorticoid receptor.

1992 • 164 citations

Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP ⁴⁰

1991 • 144 citations

Characterization of Antigen Receptor Response Elements within the Interleukin-2 Enhancer

1988 • 143 citations

Restricted production of interleukin 4 by activated human T cells.

1988 • 141 citations

Selectively increased production of interferon-gamma by subsets of Lyt-2+ and L3T4+ T cells identified by expression of Pgp-1.

1987 • 120 citations

Reduced interferon-gamma mRNA levels in human neonates. Evidence for an intrinsic T cell deficiency independent of other genes involved in T cell activation.

1986 • 118 citations

Structures of human genes coding for cytokine LD78 and their expression.

1990 • 118 citations

One-signal requirement for interferon-gamma production by human large granular lymphocytes.

1987 • 116 citations

The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.

1991 • 105 citations

Translational control of cytomegalovirus gene expression is mediated by upstream AUG codons

1988 • 104 citations

Interferons And Their Actions

1987 • 91 citations

Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes--those for GM-CSF, interleukin-4 (IL-4), and IL-5.

1991 • 87 citations

Regulation of expression of the human interferon gamma gene.

1985 • 84 citations

Molecular events involved in regulating human interferon-gamma gene expression during T cell activation.

1987 • 78 citations

Structure and function of the T cell antigen receptor.

1990 • 75 citations

Murine and Human T-Lymphocyte GATA-3 Factors Mediate Transcription through a cis-Regulatory Element within the Human T-Cell Receptor δ Gene Enhancer

1991 • 75 citations

Characterization of the human granulocyte-macrophage colony-stimulating factor promoter region by genetic analysis: correlation with DNase I footprinting.

1988 • 69 citations

Identification of enhancer-like elements in human IFN-gamma genomic DNA.

1990 • 61 citations

The human interferon‐γ gene contains an inducible promoter that can be transactivated by tax I and II

1991 • 58 citations

MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon

1991 • 54 citations

Decreased Granulocyte-Macrophage Colony-Stimulating Factor Production by Human Neonatal Blood Mononuclear Cells and T Cells

1992 • 54 citations

The Human Interferon‐γ Receptor System

1987 • 49 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1990 • 49 citations

The repeated sequence CATT(A/T) is required for granulocyte-macrophage colony-stimulating factor promoter activity.

1990 • 49 citations

A model of human cytokine regulation based on transfection of gamma interferon gene fragments directly into isolated peripheral blood T lymphocytes.

1990 • 44 citations

Gamma-interferon: an immunoregulatory lymphokine with immunotherapeutic potential.

1990 • 40 citations

Transmission Of Signals From The T Lymphocyte Antigen Receptor To The Genes Responsible For Cell Proliferation And Immune Function: The Missing Link

1990 • 34 citations

Transcription of HLA Class II Genes in the Absence of B-Cell-Specific Octamer-Binding Factor

1988 • 33 citations

Expression of human IFN-gamma genomic DNA in transgenic mice.

1989 • 28 citations

Characterization of nuclear protein binding to the interferon‐γ promoter in quiescent and activated human T cells

1992 • 27 citations

Human CD3⁻CD16⁺ natural killer cells express the hGATA‐3 T cell transcription factor and an unrearranged 2.3‐kb TcR δ transcript

1993 • 24 citations

Characterization of the Mouse Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Gene Promoter: Nuclear Factors That Interact with an Element Shared by Three Lymphokine Genes—Those for GM-CSF, Interleukin-4 (IL-4), and IL-5

1991 • 21 citations

Transcription of HLA class II genes in the absence of B-cell-specific octamer-binding factor.

1988 • 18 citations

Characterization of the Human Granulocyte-Macrophage Colony-Stimulating Factor Promoter Region by Genetic Analysis: Correlation with DNase I Footprinting

1988 • 15 citations

The Repeated Sequence CATT(A/T) Is Required for Granulocyte-Macrophage Colony-Stimulating Factor Promoter Activity

1990 • 13 citations

Structures of Human Genes Coding for Cytokine LD78 and Their Expression

1990 • 11 citations

University of Texas Medical Branch at Galveston

2000 • 9 citations