Reduced interferon-gamma (IFN-γ) secretion with increased IFN-γ mRNA expression in atopic dermatitis: evidence for a post-transcriptional defect

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.

1990 • 807 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

1991 • 641 citations

Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets.

1983 • 483 citations

Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.

1984 • 390 citations

Recombinant interferon gamma therapy for atopic dermatitis

1993 • 306 citations

Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies.

1986 • 302 citations

Sequential expression of genes involved in human T lymphocyte growth and differentiation.

1985 • 291 citations

Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production.

1983 • 288 citations

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

1992 • 284 citations

Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis

1992 • 277 citations

IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.

1990 • 262 citations

Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells.

1991 • 261 citations

Newer Concepts of Atopic Dermatitis

1977 • 259 citations

Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies

1983 • 244 citations

Regulation of Cytokine Gene Expression

1988 • 234 citations

Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells.

1989 • 228 citations

Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis

1991 • 224 citations

IL-4 and interferon-gamma production in children with atopic disease

1993 • 168 citations

Recombinant gamma interferon in treatment of patients with atopic dermatitis and elevated IgE levels

1990 • 158 citations

Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma.

1988 • 147 citations

Staphylococcal Skin Colonization in Children with Atopic Dermatitis: Prevalence, Persistence, and Transmission of Toxigenic and Nontoxigenic Strains

1992 • 139 citations

Evidence that defective interferon-gamma production in dermatitis patients is due to intrinsic abnormalities

1990 • 137 citations

Immune Dysregulation in Atopic Eczema

1992 • 117 citations

In vivo responses of CD4⁺ and CD8⁺ cells to bacterial superantigens

1992 • 109 citations

Defective IFN-gamma production in the human neonate. I. Dysregulation rather than intrinsic abnormality.

1985 • 104 citations

Kinetics of induction and molecular size of mRNAs encoding human interleukin-2 and γ-interferon

1982 • 104 citations

Increased Interleukin 6 Production by T Cells Derived from Patients with Atopic Dermatitis

1993 • 87 citations

Purified human interleukin-2 enhances induction of immune interferon

1983 • 85 citations

Soluble interleukin 2 receptor in atopic eczema.

1989 • 78 citations

Interleukin 2, interleukin 2 receptor, and interferon-γ synthesis and mRNA expression in phorbol myristate acetate and calcium lonophore A23187-stimulated T cells from elderly humans

1989 • 69 citations

Gamma‐Interferon is Produced by CD3+ and CD3‐ Lymphocytes

1987 • 64 citations

Modulation of Natural Killer Cell Activity in Patients with Atopic Dermatitis

1984 • 53 citations

Activation with superantigens induces programmed death in antigen‐primed CD4⁺ class II⁺ major histocompatibility complex T lymphocytes via a CD11a/CD18‐dependent mechanism

1993 • 51 citations

Dermatopathic Lymphadenitis12

1942 • 40 citations

Human CD4+ T cells expressing CD45RA acquire the lymphokine gene expression of CD45RO+ T-helper cells after activation in vitro.

1992 • 40 citations

Cytokine mRNA levels in antigen‐stimulated peripheral blood mononuclear cells

1989 • 38 citations

Production and secretion of interferon-gamma (IFN-γ) in children with atopic dermatitis

1994 • 35 citations

0KT3‐Induced Cytokine mRNA Expression in Human Peripheral Blood Mononuclear Cells Measured by Polymerase Chain Reaction

1992 • 31 citations

Selective Alterations in Natural Killer Cell Subsets in Patients with Atopic Dermatitis

1990 • 31 citations

Levels of Soluble Interleukin-2 Receptors Correlate with the Severity of Atopic Dermatitis

1990 • 30 citations

Spontaneous In Vivo Gene Transcription of Interleukin‐2, Interleukin‐3, Interleukin‐4, Interleukin‐6, Interferon‐Gamma, Interleukin‐2 Receptor (CD25) and Proto‐Oncogene c‐myc by Rheumatoid Synovial T Lymphocytes

1992 • 23 citations

Evidence for the presence of activated CD4 T cells with naive phenotype in the peripheral blood of patients with rheumatoid arthritis

1992 • 23 citations

Interleukin-1 release from peripheral blood monocytes and soluble interleukin-2 and CD8 receptors in serum from patients with atopic dermatitis.

1990 • 20 citations

Cytokine release from cultured peripheral blood mononuclear cells of patients with severe atopic dermatitis.

1989 • 20 citations

Interferon-γ mRNA expression upon in vitro T lymphocyte activation is decreased in rheumatoid arthritis patients

1990 • 14 citations

Lymphokine production by human peripheral blood lymphocytes: analysis by in situ hybridization.

1988 • 10 citations

Detection of Cytokine mRNA in Polyclonally‐, Antigen‐ or Allergen‐Stimulated Mononuclear Cells

1991 • 9 citations

In Situ Hybridization of Interferon‐Gamma Producing Peripheral Blood Mononuclear Cells

1991 • 8 citations

Diagnosis and Grading (Severity)

1989 • 7 citations

In vitro generation of IFN-gamma in relationship to in vivo concentration of IgE and IgG subclasses and Fc epsilon Rl/CD23 positive circulating lymphocytes in patients with severe atopic dermatitis (AD).

1989 • 6 citations