Regulation of interferon‐γ mRNA in a cytolytic T cell clone: Ca²⁺‐induced transcription followed by mRNA stabilization through activation of protein kinase C or increase in cAMP

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

1992 • 811 citations

Transcriptional regulation of hemoglobin switching in chicken embryos.

1981 • 800 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Comparison of three actin-coding sequences in the mouse; Evolutionary relationships between the actin genes of warm-blooded vertebrates

1986 • 678 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Cloning and expression of murine immune interferon cDNA.

1983 • 455 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

Estrogen regulates the IFN-gamma promoter.

1991 • 409 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant.

1992 • 301 citations

Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A.

1986 • 293 citations

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.

1991 • 293 citations

Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity.

1985 • 286 citations

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

1992 • 284 citations

Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.

1989 • 256 citations

The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs.

1991 • 222 citations

Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.

1990 • 218 citations

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

1993 • 203 citations

Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter.

1993 • 202 citations

Location of cAMP-Dependent Protein Kinase Type I with the TCR-CD3 Complex

1994 • 200 citations

Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP ⁴⁰

1991 • 144 citations

Cell specificity of granzyme gene expression.

1990 • 136 citations

Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes.

1993 • 129 citations

Tumor necrosis factor alpha-induced glucose transporter (GLUT-1) mRNA stabilization in 3T3-L1 preadipocytes. Regulation by the adenosine-uridine binding factor.

1992 • 112 citations

Interferon-γ: Producer cells, activation stimuli, and molecular genetic regulation

1990 • 110 citations

Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C.

1993 • 82 citations

Role of cAMP in regulating cytotoxic T lymphocyte adhesion and motility

1993 • 66 citations

MOLECULAR AND GENETIC INSIGHTS INTO T CELL ANTIGEN RECEPTOR STRUCTURE AND FUNCTION

1991 • 65 citations

Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay.

1992 • 63 citations

Identification of enhancer-like elements in human IFN-gamma genomic DNA.

1990 • 61 citations

Control of messenger RNA stability

1987 • 61 citations

The human interferon‐γ gene contains an inducible promoter that can be transactivated by tax I and II

1991 • 58 citations

Interactions between MHC-encoded products and cloned T-cells. I. Fine specificity of induction of proliferation and lysis

1982 • 55 citations

Transcriptional and posttranscriptional regulation of the interleukin-4 and interleukin-3 genes in human T cells

1993 • 49 citations

Early events of human T lymphocyte activation are associated with type I protein kinase A activity.

1993 • 45 citations

Actinomycin prevents the destabilization of neurofilament mRNA in primary sensory neurons.

1992 • 44 citations

The dual role of the cAMP-dependent protein kinase C alpha subunit in T-cell receptor-triggered T-lymphocytes effector functions.

1992 • 32 citations

Effect of prostaglandin E2 (PGE2) on IL-3/granulocyte-macrophage colony-stimulating factor production by T helper cells. Mode of stimulation and presence of costimulation can determine response to PGE2.

1993 • 32 citations

Characterization of nuclear protein binding to the interferon‐γ promoter in quiescent and activated human T cells

1992 • 27 citations

T-dependent destruction of thyroid isografts exposed to IFN-gamma.

1991 • 23 citations

An RNasin-resistant ribonuclease selective for interleukin 2 mRNA

1993 • 20 citations

Cyclic AMP synergy with Ca2+ for production of IFN-gamma by a cytolytic T cell clone is post-transcriptional.

1991 • 8 citations