Inflammatory Bowel Disease Mucosal Biopsies Have Specialized Lymphokine mRNA Profiles

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Hapten-induced model of chronic inflammation and ulceration in the rat colon

1989 • 706 citations

B-Cell Stimulatory Factor-1/Interleukin 4

1987 • 602 citations

Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis.

1985 • 462 citations

A Placebo-Controlled, Double-Blind, Randomized Trial of Cyclosporine Therapy in Active Chronic Crohn's Disease

1989 • 380 citations

Recent Developments in Nonspecific Inflammatory Bowel Disease

1982 • 341 citations

Intestinal permeability in patients with Crohn's disease and their healthy relatives

1989 • 305 citations

Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.

1991 • 277 citations

Differential activation requirements for virgin and memory T cells.

1988 • 271 citations

A comparative analysis of two models of colitis in rats

1992 • 265 citations

Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome.

1988 • 225 citations

Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis

1992 • 220 citations

CD4+ subset regulation in viral infection. Preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice.

1992 • 213 citations

Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease

1991 • 207 citations

Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis.

1992 • 202 citations

Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice

1993 • 193 citations

Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens.

1987 • 182 citations

Isolation and characterization of a colonic autoantigen specifically recognized by colon tissue-bound immunoglobulin G from idiopathic ulcerative colitis.

1985 • 164 citations

Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion.

1993 • 163 citations

Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells

1991 • 149 citations

The immunologic basis of inflammatory bowel disease

1986 • 140 citations

T cell antigen receptor V gene usage. Increases in V beta 8+ T cells in Crohn's disease.

1990 • 113 citations

T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine

1993 • 100 citations

The role of interleukin 2 in autoimmunity

1989 • 89 citations

Aberrant interleukin (IL)‐4 and IL‐5 production in vitro by CD4⁺ helper T cells from atopic subjects

1992 • 88 citations

Predominance of T_h1‐type T cells in synovial fluid of patients with Yersinia‐induced reactive arthritis

1992 • 86 citations

Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity

1985 • 85 citations

Pathogenetic and clinical relevance of cytokines in inflammatory bowel disease

1991 • 73 citations

T-cell activation in Crohn's disease

1990 • 71 citations

A Role for CD4⁺ T‐Cell Subsets Producing a Selective Pattern of Lymphokines in the Pathogenesis of Human Chronic Inflammatory and Allergic Diseases

1991 • 64 citations

Interleukin 5 and its receptor

1991 • 63 citations

Human mucosal T-cell cytotoxicity

1988 • 41 citations

Symptomatic Exacerbation of Crohn Disease after Treatment with High-Dose Interleukin-2

1993 • 41 citations

Ability of human colonic epithelium to express the 4F2 antigen, the common acute lymphoblastic leukemia antigen, and the transferrin receptor

1989 • 33 citations

Production of inflammatory cytokines in the intestinal lamina propria

1991 • 31 citations

Modulation of intestinal immune reactivity by interleukin 2

1988 • 29 citations

Evidence for an Altered T-Cell Receptor Repertoire in Crohn's Disease

1994 • 27 citations

Quantitative Measurement of Human T-Cell Receptor Vβ Subfamilies by Reverse Transcription-Polymerase Chain Reaction Using Synthetic Internal mRNA Standards

1993 • 21 citations

Limited T-cell receptor beta-chain diversity of a T-helper cell type 1-like response to Mycobacterium leprae

1992 • 17 citations

Neutrophil autoantibodies as disease markers for ulcerative colitis

1991 • 16 citations