Mechanisms of Human Papillomavirus-Induced Oncogenesis

The Hallmarks of Cancer

2000 • 27,569 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Papillomaviruses and cancer: from basic studies to clinical application

2002 • 3,873 citations

Proliferation, cell cycle and apoptosis in cancer

2001 • 3,236 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers

2000 • 3,004 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

DNA methylation and epigenetic inheritance

1990 • 2,198 citations

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

1983 • 2,011 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

1998 • 1,206 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

Modelling the molecular circuitry of cancer

2002 • 948 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

1996 • 904 citations

Telomerase activation by the E6 gene product of human papillomavirus type 16

1996 • 825 citations

From polyploidy to aneuploidy, genome instability and cancer

2004 • 798 citations

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

1987 • 760 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

1998 • 602 citations

Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

2001 • 592 citations

Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells

1995 • 577 citations

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1993 • 537 citations

Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis.

1995 • 529 citations

Stem cells of the skin epithelium

2003 • 516 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

2000 • 483 citations

Using GFP in FRET-based applications

1999 • 482 citations

Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix.

1996 • 470 citations

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

1997 • 462 citations

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21^Cip1-mediated inhibition of cdk2

1997 • 461 citations

THE PROGRESSION TO CARCINOMA OF VIRUS-INDUCED RABBIT PAPILLOMAS (SHOPE)

1935 • 454 citations

Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways

2000 • 442 citations

The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300

1999 • 417 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Interaction of the Bovine Papillomavirus E2 Protein with Brd4 Tethers the Viral DNA to Host Mitotic Chromosomes

2004 • 395 citations

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

1992 • 389 citations

Identification of the alpha6 integrin as a candidate receptor for papillomaviruses

1997 • 384 citations

The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability.

2002 • 382 citations

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.

1988 • 377 citations

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

1997 • 376 citations

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1994 • 371 citations

Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteins

2003 • 364 citations

Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes.

1995 • 346 citations

Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome

1987 • 341 citations

Emerging roles for E2F: Beyond the G1/S transition and DNA replication

2003 • 334 citations

Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein.

1996 • 329 citations

Specific interaction between HPV-16 E1–E4 and cytokeratins results in collapse of the epithelial cell intermediate filament network

1991 • 327 citations

Molecular cloning of viral DNA from human genital warts

1981 • 326 citations

The Human Papillomavirus Type 16 E6 Oncoprotein Can Down-Regulate p53 Activity by Targeting the Transcriptional Coactivator CBP/p300

1999 • 325 citations

Chapter 8: Human Papillomavirus and Skin Cancer

2003 • 324 citations

The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

1996 • 323 citations

The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth

1999 • 313 citations

Degradation of the Retinoblastoma Tumor Suppressor by the Human Papillomavirus Type 16 E7 Oncoprotein Is Important for Functional Inactivation and Is Separable from Proteasomal Degradation of E7

2001 • 312 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins.

1992 • 302 citations

Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis.

2003 • 298 citations

The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.

1987 • 294 citations

Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice.

1996 • 293 citations

Partial characterization of viral DNA from human genital warts (condylomata acuminata)

1980 • 279 citations

Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein

2001 • 279 citations

The papillomavirus E2 regulatory proteins.

1991 • 276 citations

Interaction of Papillomavirus E6 Oncoproteins with a Putative Calcium-Binding Protein

1995 • 272 citations

Human papillomavirus life cycle: active and latent phases

1999 • 271 citations

Destabilization of the RB Tumor Suppressor Protein and Stabilization of p53 Contribute to HPV Type 16 E7-Induced Apoptosis

1997 • 260 citations

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton

1997 • 258 citations

Common fragile sites are preferential targets for HPV16 integrations in cervical tumors

2003 • 247 citations

The Role of E6AP in the Regulation of p53 Protein Levels in Human Papillomavirus (HPV)-positive and HPV-negative Cells

1998 • 247 citations

Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter

2003 • 240 citations

Papillomavirus polypeptides E6 and E7 are zinc-binding proteins

1989 • 239 citations

The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties

1990 • 238 citations

Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding Sites

2001 • 234 citations

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

1995 • 234 citations

The Human Papillomavirus Type 16 E7 Oncogene Is Required for the Productive Stage of the Viral Life Cycle

2000 • 226 citations

The PDZ Ligand Domain of the Human Papillomavirus Type 16 E6 Protein Is Required for E6's Induction of Epithelial Hyperplasia In Vivo

2003 • 221 citations

The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes

1989 • 218 citations

The E5 gene from human papillomavirus type 16 is an oncogene which enhances growth factor-mediated signal transduction to the nucleus.

1992 • 207 citations

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21CIP-dependent pathways

2000 • 206 citations

Acquisition of High-Level Chromosomal Instability Is Associated with Integration of Human Papillomavirus Type 16 in Cervical Keratinocytes

2004 • 205 citations

Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes

1999 • 198 citations

Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype.

2001 • 197 citations

Human Papillomavirus Type 31 E5 Protein Supports Cell Cycle Progression and Activates Late Viral Functions upon Epithelial Differentiation

2003 • 193 citations

Cloning and Expression of the cDNA for E6-AP, a Protein that Mediates the Interaction of the Human Papillomavirus E6 Oncoprotein with p53

1993 • 190 citations

E Box-Dependent Activation of Telomerase by Human Papillomavirus Type 16 E6 Does Not Require Induction of c- myc

2001 • 187 citations

Mechanisms of cell transformation by papillomavirus E5 proteins

2001 • 186 citations

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein

1997 • 183 citations

Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes

1999 • 182 citations

Bovine Papillomavirus Type 1 Genomes and the E2 Transactivator Protein Are Closely Associated with Mitotic Chromatin

1998 • 178 citations

Transcriptional trans-activation by the human papillomavirus type 16 E2 gene product

1987 • 173 citations

Down Regulation of the Interleukin-8 Promoter by Human Papillomavirus Type 16 E6 and E7 through Effects on CREB Binding Protein/p300 and P/CAF

2002 • 169 citations

A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques

2003 • 164 citations

Quantitative Role of the Human Papillomavirus Type 16 E5 Gene during the Productive Stage of the Viral Life Cycle

2003 • 163 citations

The Binding of Histone Deacetylases and the Integrity of Zinc Finger-Like Motifs of the E7 Protein Are Essential for the Life Cycle of Human Papillomavirus Type 31

2004 • 162 citations

Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle Checkpoint

1998 • 153 citations

Destabilization of the Retinoblastoma Tumor Suppressor by Human Papillomavirus Type 16 E7 Is Not Sufficient To Overcome Cell Cycle Arrest in Human Keratinocytes

2001 • 153 citations

Human Papillomavirus Oncoprotein E6 Inactivates the Transcriptional Coactivator Human ADA3

2002 • 146 citations

PDZ domains-glue and guide.

2003 • 138 citations

Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300

2003 • 135 citations

Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.

1993 • 135 citations

Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding

1993 • 135 citations

Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

1998 • 132 citations

Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene

1989 • 128 citations

Evidence for a Nonallelic Heterogeneity of Epidermodysplasia Verruciformis with Two Susceptibility Loci Mapped to Chromosome Regions 2p21–p24 and 17q25

2000 • 128 citations

Derivation of human tumor cells in vitro without widespread genomic instability.

2001 • 126 citations

Evolving views of telomerase and cancer

2003 • 125 citations

The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints

1997 • 121 citations

Different mechanisms contribute to the E2-mediated transcriptional repression of human papillomavirus type 18 viral oncogenes

1997 • 120 citations

Centrosome Abnormalities and Genomic Instability by Episomal Expression of Human Papillomavirus Type 16 in Raft Cultures of Human Keratinocytes

2001 • 120 citations

HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation

2001 • 117 citations

Interaction of the HPV E7 proteins with the pCAF acetyltransferase

2003 • 115 citations

Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial Cells

2002 • 110 citations

Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein.

1997 • 110 citations

Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells

1997 • 110 citations

Roles of the E6 and E7 Proteins in the Life Cycle of Low-Risk Human Papillomavirus Type 11

2004 • 109 citations

Changes in cervical keratinocyte gene expression associated with integration of human papillomavirus 16.

2002 • 107 citations

Human Papillomavirus Type 16 E7 Oncoprotein Can Induce Abnormal Centrosome Duplication through a Mechanism Independent of Inactivation of Retinoblastoma Protein Family Members

2003 • 107 citations

Recapitulation of the Effects of the Human Papillomavirus Type 16 E7 Oncogene on Mouse Epithelium by Somatic Rb Deletion and Detection of pRb-Independent Effects of E7 In Vivo

2003 • 105 citations

Expression of HPV16 E6 or E7 increases integration of foreign DNA.

1996 • 102 citations

Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteins

1992 • 99 citations

Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18

1997 • 97 citations

X-linked inheritance of epidermodysplasia verruciformis. Genetic and virologic studies of a kindred.

1985 • 97 citations

Identification of an α Helical Motif Sufficient for Association with Papillomavirus E6

1998 • 96 citations

The Bovine Papillomavirus E6 Protein Binds to the LD Motif Repeats of Paxillin and Blocks Its Interaction with Vinculin and the Focal Adhesion Kinase

1997 • 91 citations

Koilocytotic lesions of the cervix. The relationship of mitotic abnormalities to the presence of papillomavirus antigens and nuclear dna content

1984 • 90 citations

Characterization of a human papillomavirus from epidermodysplasia verruciformis lesions of a patient from upper‐volta

1981 • 88 citations

X-linked Inheritance of Epidermodysplasia Verruciformis

1985 • 86 citations

Human Papillomavirus Type 16 E6 and E7 Cause Polyploidy in Human Keratinocytes and Up-Regulation of G2-M-Phase Proteins

2004 • 86 citations

Genetic Analysis of High-Risk E6 in Episomal Maintenance of Human Papillomavirus Genomes in Primary Human Keratinocytes

2002 • 84 citations

Pathobiology of vulvar squamous neoplasia

1997 • 81 citations

Anal cancer: an HIV-associated cancer

2003 • 67 citations

The identification of a conserved binding motif within human papillomavirus type 16 E6 binding peptides, E6AP and E6BP.

1998 • 66 citations

Human adenovirus type 9-induced rat mammary tumors

1991 • 65 citations

A Genomic Approach Reveals a Novel Mitotic Pathway in Papillomavirus Carcinogenesis

2004 • 63 citations

The fabric of cancer cell biology—Weaving together the strands

2002 • 60 citations

Requirement for the Adenovirus type 9 E4 Region in Production of Mammary Tumors

1992 • 60 citations

E6 and E7 Oncoproteins Induce Distinct Patterns of Chromosomal Aneuploidy in Skin Tumors from Transgenic Mice

2004 • 55 citations

Dimerization of the Human Papillomavirus E7 Oncoproteinin Vivo

1995 • 53 citations

Cotransfection of HPV-18 and v-fos DNA Induces Tumorigenicity of Primary Human Keratinocytes

1993 • 48 citations

Identification of an Immunologically Distinct Papillomavirus From Lesions of Epidermodysplasia Verruciformis 2

1977 • 48 citations

Possible involvement of epidermodysplasia verruciformis human papillomaviruses in the immunopathogenesis of psoriasis: a proposed hypothesis

2003 • 40 citations

On the Viral Etiology of Epidermodysplasia Verruciformis

1966 • 39 citations

Übertragungsversuche mit spitzem Kondylom

1918 • 37 citations

OBSERVATIONS ON THE RELATION OF THE VIRUS CAUSING RABBIT PAPILLOMAS TO THE CANCERS DERIVING THEREFROM

1936 • 36 citations

OBSERVATIONS ON THE RELATION OF THE VIRUS CAUSING RABBIT PAPILLOMAS TO THE CANCERS DERIVING THEREFROM

1936 • 33 citations

Molecular pathways executing the “trophic sentinel” response in HPV-16 E7-expressing normal human diploid fibroblasts upon growth factor deprivation

2003 • 33 citations

Simultaneous human papilloma virus type 16 E7 and cdk inhibitor p21 expression induces apoptosis and cathepsin B activation

2004 • 31 citations

A recurrent gain of chromosome arm 3q in primary squamous carcinoma of the vagina

2003 • 24 citations

THE ETIOLOGY OF COMMON WARTS

1921 • 24 citations

Koilocytotic lesions of the cervix

1986 • 21 citations

Deleted Work

1955 • 0 citations