Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein.

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

1996 • 904 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

1991 • 592 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

1992 • 389 citations

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1994 • 371 citations

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation

1990 • 358 citations

Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes.

1995 • 346 citations

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

1995 • 336 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.

1992 • 327 citations

A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.

1996 • 251 citations

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

1994 • 243 citations

DNA tumor virus transforming proteins and the cell cycle

1993 • 242 citations

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

1992 • 233 citations

Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation

1993 • 212 citations

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.

1990 • 197 citations

Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation

1995 • 195 citations

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein

1997 • 183 citations

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes

1992 • 177 citations

The retinoblastoma protein as a transcriptional repressor

1993 • 176 citations

The Human Papillomavirus E7 Oncoprotein Functionally Interacts with the S4 Subunit of the 26 S Proteasome

1997 • 148 citations

Human Papillomavirus E7 Oncoproteins Bind a Single Form of Cyclin E in a Complex with cdk2 and p107

1996 • 147 citations

Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding

1993 • 135 citations

The biology of human papillomaviruses: from warts to cancer.

1993 • 117 citations

Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex.

1993 • 113 citations

Association of p107 with Sp1: Genetically Separable Regions of p107 Are Involved in Regulation of E2F- and Sp1-Dependent Transcription

1995 • 98 citations

p21 Disrupts the Interaction between cdk2 and the E2F-p130 Complex

1996 • 86 citations

Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation.

1994 • 84 citations

Initiation of DNA synthesis by human papillomavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activity

1997 • 64 citations

Interactions Between Papillomavirus Proteins and Tumor Suppressor Gene Products

1994 • 61 citations

Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein

1992 • 56 citations

Accumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21

1997 • 55 citations

Activation of the c-fos gene by the HPV16 oncoproteins depends upon the cAMP-response element at -60

1994 • 45 citations

Prevalence of Epstein‐Barr virus and human papillomavirus in oral mucosa of HIV‐Infected patients

1992 • 44 citations

HPV16 E6 Oncoprotein Stimulates the Transforming Growth Factor-β1 Promoter in Fibroblasts through a Specific GC-Rich Sequence

1997 • 33 citations