Roles of the E6 and E7 Proteins in the Life Cycle of Low-Risk Human Papillomavirus Type 11

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis

2000 • 1,313 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

Telomerase activation by the E6 gene product of human papillomavirus type 16

1996 • 825 citations

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1993 • 537 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

HUMAN PAPILLOMAVIRUSES

1994 • 470 citations

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

1997 • 462 citations

The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300

1999 • 417 citations

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.

1992 • 327 citations

The Human Papillomavirus Type 16 E6 Oncoprotein Can Down-Regulate p53 Activity by Targeting the Transcriptional Coactivator CBP/p300

1999 • 325 citations

Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins

2000 • 296 citations

Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation

1999 • 295 citations

Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein

2001 • 279 citations

Interaction of Papillomavirus E6 Oncoproteins with a Putative Calcium-Binding Protein

1995 • 272 citations

Differentiation-induced and constitutive transcription of human papillomavirus type 31b in cell lines containing viral episomes

1992 • 267 citations

Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms

1989 • 264 citations

Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins

2000 • 259 citations

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

1994 • 259 citations

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton

1997 • 258 citations

Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding Sites

2001 • 234 citations

The Human Papillomavirus Type 16 E7 Oncogene Is Required for the Productive Stage of the Viral Life Cycle

2000 • 226 citations

Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types.

1999 • 209 citations

In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression.

1996 • 198 citations

Multiple Functions of Human Papillomavirus Type 16 E6 Contribute to the Immortalization of Mammary Epithelial Cells

1999 • 198 citations

Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes

1999 • 198 citations

Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73

1998 • 194 citations

Human Papillomavirus Type 31 E5 Protein Supports Cell Cycle Progression and Activates Late Viral Functions upon Epithelial Differentiation

2003 • 193 citations

Cloning and Expression of the cDNA for E6-AP, a Protein that Mediates the Interaction of the Human Papillomavirus E6 Oncoprotein with p53

1993 • 190 citations

High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation

1996 • 189 citations

E Box-Dependent Activation of Telomerase by Human Papillomavirus Type 16 E6 Does Not Require Induction of c- myc

2001 • 187 citations

E3-Ubiquitin Ligase/E6-AP Links Multicopy Maintenance Protein 7 to the Ubiquitination Pathway by a Novel Motif, the L2G Box

1998 • 180 citations

Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

1998 • 132 citations

The biology of human papillomaviruses: from warts to cancer.

1993 • 117 citations

HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation

2001 • 117 citations

HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase

2000 • 104 citations

The Bovine Papillomavirus E6 Protein Binds to the LD Motif Repeats of Paxillin and Blocks Its Interaction with Vinculin and the Focal Adhesion Kinase

1997 • 91 citations

Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells

1996 • 88 citations

Genetic Analysis of High-Risk E6 in Episomal Maintenance of Human Papillomavirus Genomes in Primary Human Keratinocytes

2002 • 84 citations

Human Papillomavirus Oncoprotein E6 Binds to the C-Terminal Region of Human Minichromosome Maintenance 7 Protein

1998 • 80 citations

Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins

2001 • 73 citations

Human papillomavirus type 31b late gene expression is regulated through protein kinase C-mediated changes in RNA processing

1995 • 73 citations

Mechanism of HPV E6 proteins in cellular transformation

1996 • 70 citations

Human Papillomavirus Type 31 Replication Modes during the Early Phases of the Viral Life Cycle Depend on Transcriptional and Posttranscriptional Regulation of E1 and E2 Expression

2002 • 62 citations

Interaction of Zyxin, a Focal Adhesion Protein, with the E6 Protein from Human Papillomavirus Type 6 Results in Its Nuclear Translocation

2001 • 60 citations

Cellular Changes Induced by Low-Risk Human Papillomavirus Type 11 in Keratinocytes That Stably Maintain Viral Episomes

2001 • 59 citations

Gps2, a Protein Partner for Human Papillomavirus E6 Proteins

2001 • 56 citations

Role of E6 and E7 oncoproteins in HPV-induced anogenital malignancies

1996 • 43 citations

Differential regulation of human papillomavirus type 6 and 11 early promoters in cultured cells derived from laryngeal papillomas

1995 • 41 citations

The interaction between p53 and papillomaviruses

1999 • 41 citations

Mutational analysis of the discs large tumour suppressor identifies domains responsible for human papillomavirus type 18 E6-mediated degradation

2002 • 34 citations

Heterogeneity of papillomaviruses

1996 • 30 citations