Human papillomavirus life cycle: active and latent phases

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Papillomavirus infections — a major cause of human cancers

1996 • 1,536 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Telomerase activation by the E6 gene product of human papillomavirus type 16

1996 • 825 citations

Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

1986 • 665 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

1998 • 602 citations

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1993 • 537 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

Latent Papillomavirus and Recurring Genital Warts

1985 • 485 citations

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21^Cip1-mediated inhibition of cdk2

1997 • 461 citations

Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma

1982 • 452 citations

Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.

1986 • 440 citations

The L1 Major Capsid Protein of Human Papillomavirus Type 11 Recombinant Virus-like Particles Interacts with Heparin and Cell-surface Glycosaminoglycans on Human Keratinocytes

1999 • 415 citations

Analysis of genomic sequences of 95 papillomavirus types: uniting typing, phylogeny, and taxonomy

1995 • 415 citations

Epidermal stem cells: markers, patterning and the control of stem cell fate

1998 • 398 citations

Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator

1990 • 396 citations

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

1992 • 389 citations

Identification of the alpha6 integrin as a candidate receptor for papillomaviruses

1997 • 384 citations

Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes.

1995 • 346 citations

Cancers of the anogenital region in renal transplant recipients: Analysis of 65 cases

1986 • 331 citations

Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA

1987 • 330 citations

Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein.

1996 • 329 citations

Laryngeal Papillomavirus Infection during Clinical Remission

1983 • 299 citations

Activation of BPV-1 replication in vitro by the transcription factor E2

1991 • 284 citations

The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells

1992 • 280 citations

Human papilloma viruses (HPV): Characterization of four different isolates

1977 • 280 citations

The papillomavirus E2 regulatory proteins.

1991 • 276 citations

Interaction of Papillomavirus E6 Oncoproteins with a Putative Calcium-Binding Protein

1995 • 272 citations

Differentiation-induced and constitutive transcription of human papillomavirus type 31b in cell lines containing viral episomes

1992 • 267 citations

Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms

1989 • 264 citations

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton

1997 • 258 citations

Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1.

1991 • 257 citations

Characterization of a New Type of Human Papillomavirus That Causes Skin Warts

1977 • 256 citations

The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties

1990 • 238 citations

The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.

1993 • 236 citations

The nucleotide sequence and genome organization of human papilloma virus type 11

1986 • 232 citations

Prevailing papillomavirus types in non-melanoma carcinomas of the skin in renal allograft recipients

1997 • 230 citations

Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication.

1993 • 200 citations

Detection of novel splicing patterns in a HPV16-containing keratinocyte cell line

1990 • 200 citations

Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes

1999 • 198 citations

Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome.

1989 • 195 citations

Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.

1995 • 184 citations

Transient replication of human papillomavirus DNAs

1992 • 177 citations

Bovine papilloma virus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin.

1993 • 165 citations

The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase.

1994 • 156 citations

Identification of a differentiation-inducible promoter in the E7 open reading frame of human papillomavirus type 16 (HPV-16) in raft cultures of a new cell line containing high copy numbers of episomal HPV-16 DNA

1996 • 153 citations

A C-Terminal Helicase Domain of the Human Papillomavirus E1 Protein Binds E2 and the DNA Polymerase α-Primase p68 Subunit

1998 • 152 citations

E1 protein of human papillomavirus is a DNA helicase/ATPase

1993 • 149 citations

Human Papillomavirus E7 Oncoproteins Bind a Single Form of Cyclin E in a Complex with cdk2 and p107

1996 • 147 citations

Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1

1994 • 143 citations

HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A.

1993 • 141 citations

Binding of the human papillomavirus E1 origin-recognition protein is regulated through complex formation with the E2 enhancer-binding protein.

1994 • 138 citations

Identification of Papillomaviruses in Butchers' Warts

1981 • 138 citations

The relationship between human papillomavirus and lower genital intraepithelial neoplasia in immunosuppressed women

1984 • 133 citations

Cloning of human papilloma virus genomic DNAs and analysis of homologous polynucleotide sequences

1980 • 133 citations

A human papilloma virus type 11 transcript encoding an E1^E4 protein

1987 • 125 citations

Papillomavirus and HPV typing

1997 • 124 citations

Human Papillomavirus DNA Replication

1999 • 121 citations

Malignant disease in renal transplant patients.

1985 • 119 citations

Recruitment and loading of the E1 initiator protein: an ATP-dependent process catalysed by a transcription factor

1998 • 114 citations

The 68-kilodalton E1 protein of bovine papillomavirus is a DNA binding phosphoprotein which associates with the E2 transcriptional activator in vitro

1991 • 112 citations

Epidemiology of Human papillomavirus (HPV) infections and their associations with genital squamous cell cancer

1989 • 109 citations

The primary target cells of the high-risk cottontail rabbit papillomavirus colocalize with hair follicle stem cells

1996 • 101 citations

Interactions of the Papovavirus DNA Replication Initiator Proteins, Bovine Papillomavirus Type 1 E1 and Simian Virus 40 Large T Antigen, with Human Replication Protein A

1999 • 95 citations

Human Papillomavirus Type 31b E1 and E2 Transcript Expression Correlates with Vegetative Viral Genome Amplification

1998 • 94 citations

Differential Requirements for Conserved E2 Binding Sites in the Life Cycle of Oncogenic Human Papillomavirus Type 31

1998 • 92 citations

The Functions of Human Papillomavirus Type 11 E1, E2, and E2C Proteins in Cell-free DNA Replication

1995 • 88 citations

Human papillomavirus DNA: physical map.

1975 • 87 citations

A Comparative Analysis of the Interactions of the E6 Proteins from Cutaneous and Genital Papillomaviruses with p53 and E6AP in Correlation to Their Transforming Potential

1997 • 84 citations

Identification and mapping of human papillomavirus type 1 RNA transcripts recovered from plantar warts and infected epithelial cell cultures.

1987 • 84 citations

The bovine papillomavirus E2 protein modulates the assembly of but is not stably maintained in a replication-competent multimeric E1-replication origin complex.

1994 • 83 citations

Differentiation-Induced Changes in Promoter Usage for Transcripts Encoding the Human Papillomavirus Type 31 Replication Protein E1

1999 • 77 citations

Bovine papillomavirus E1 protein binds specifically DNA polymerase alpha but not replication protein A

1995 • 74 citations

Human papillomavirus type 31b late gene expression is regulated through protein kinase C-mediated changes in RNA processing

1995 • 73 citations

Cooperative assembly of the bovine papilloma virus E1 and E2 proteins on the replication origin requires an intact E2 binding site

1993 • 72 citations

Regression of papillomas induced by cottontail rabbit papillomavirus is associated with infiltration of CD8+ cells and persistence of viral DNA after regression

1997 • 71 citations

Human Papillomavirus Type 11 Transcripts Are Present at Low Abundance in Latently Infected Respiratory Tissues

1995 • 69 citations

Human Papillomavirus Type 18 E1 Protein Is Translated from Polycistronic mRNA by a Discontinuous Scanning Mechanism

1999 • 69 citations

New perspectives on retinoblastoma family functions in differentiation

1998 • 65 citations

Human Papillomavirus Oncoproteins Alter Differentiation-Dependent Cell Cycle Exit on Suspension in Semisolid Medium

1998 • 65 citations

DNA Replication of Human Papillomavirus Type 31 Is Modulated by Elements of the Upstream Regulatory Region That Lie 5′ of the Minimal Origin

1999 • 63 citations

Human papillomavirus (HPV) type 16 and 33 E6/E7 region transcripts in tonsillar carcinomas can originate from integrated and episomal HPV DNA

1992 • 59 citations

Characterization of human papillomavirus type 11 E1 and E2 proteins expressed in insect cells

1993 • 59 citations

Latent infection induced with cottontail rabbit papillomavirus. A model for human papillomavirus latency.

1994 • 56 citations

Regulation of Human Papillomavirus Type 31 Polyadenylation during the Differentiation-Dependent Life Cycle

1999 • 47 citations

Histological Distribution of Polymerase Chain Reaction-Amplified Human Papillomavirus 6 and 11 DNA in Penile Lesions

1992 • 44 citations

Differential regulation of human papillomavirus type 6 and 11 early promoters in cultured cells derived from laryngeal papillomas

1995 • 41 citations

Human papillomaviruses target differentiating epithelia for virion production and malignant conversion

1996 • 40 citations

Epidemiology of Human Papillomaviruses

1995 • 35 citations

HPV6 Variants from Malignant Tumors with Sequence Alterations in the Regulatory Region Do Not Reveal Differences in the Activities of the Oncogene Promoters but Do Contain Amino Acid Exchanges in the E6 and E7 Proteins

1996 • 33 citations

Molecular cloning and characterization of human papillomavirus type 7 DNA

1986 • 31 citations

Papillomaviruses and Carcinogenic Progression I

1987 • 30 citations

High-risk factors in gynecologic cancer

1981 • 26 citations

Does human papillomavirus infection play a role in non-melanoma skin cancer?

1996 • 16 citations