Wild Type p53 Activity Contributes to Dependence on Hematopoietic Survival Factors

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

p53 function and dysfunction

1992 • 1,918 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Apoptosis: The Molecular Basis of Cell Death

1991 • 425 citations

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

1992 • 344 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

Regulation of the Human hsp70 Promoter by p53

1993 • 297 citations

Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells.

1993 • 280 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

p53: the ultimate tumor suppressor gene?

1992 • 209 citations

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.

1993 • 196 citations

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.

1993 • 162 citations

Growth Suppression of Friend Virus-Transformed Erythroleukemia Cells by p53 Protein Is Accompanied by Hemoglobin Production and Is Sensitive to Erythropoietin

1993 • 140 citations

The p53 tumor suppressor protein: meeting review.

1993 • 128 citations

Interferons and interleukin 6 suppress phosphorylation of the retinoblastoma protein in growth-sensitive hematopoietic cells.

1992 • 120 citations

p53 Mutations: Gains or losses?

1991 • 111 citations

The control of growth and differentiation in normal and leukemic blood cells

1990 • 79 citations

Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin.

1993 • 77 citations

Cell cycle regulation and the p53 tumor suppressor protein.

1992 • 52 citations