Nuclear Import of IκBα Is Accomplished by a Ran-Independent Transport Pathway

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1997 • 1,195 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

1998 • 1,184 citations

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

1997 • 1,144 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

Structure of an IκBα/NF-κB Complex

1998 • 792 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

Isolation of a protein that is essential for the first step of nuclear protein import

1994 • 710 citations

A Novel Receptor-Mediated Nuclear Protein Import Pathway

1996 • 669 citations

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

1997 • 628 citations

Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

1997 • 613 citations

The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

1998 • 563 citations

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

1995 • 511 citations

Distinct functions for the two importin subunits in nuclear protein import

1995 • 479 citations

Synthetic peptides as nuclear localization signals

1986 • 472 citations

The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex

1995 • 460 citations

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.

1994 • 453 citations

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

1995 • 442 citations

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

1995 • 430 citations

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin

1998 • 429 citations

Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm

1997 • 405 citations

THE NUCLEAR PORE COMPLEX

1995 • 383 citations

The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.

1989 • 367 citations

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

1997 • 365 citations

Sequence and characterization of cytoplasmic nuclear protein import factor p97.

1995 • 274 citations

An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of Ikappa Balpha

1999 • 264 citations

Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

1995 • 264 citations

Rel-Associated pp40: an Inhibitor of the Rel Family of Transcription Factors

1991 • 255 citations

RanBP1 is crucial for the release of RanGTP from importin β‐related nuclear transport factors

1997 • 250 citations

β-Catenin Can Be Transported into the Nucleus in a Ran-unassisted Manner

1999 • 235 citations

Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation

1999 • 232 citations

The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus.

1990 • 228 citations

The Specificity of the CRM1-Rev Nuclear Export Signal Interaction Is Mediated by RanGTP

1998 • 221 citations

Characterization of HIV-1 Vpr Nuclear Import: Analysis of Signals and Pathways

1998 • 186 citations

Requirement of Guanosine Triphosphate-Bound Ran for Signal-Mediated Nuclear Protein Export

1997 • 183 citations

Nucleocytoplasmic Shuttling Factors Including Ran and CRM1 Mediate Nuclear Export of NFAT In Vitro

1998 • 175 citations

Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis

1999 • 167 citations

Ran-unassisted Nuclear Migration of a 97-kD Component of Nuclear Pore–targeting Complex

1997 • 160 citations

Nuclear Localization of IκBα Is Mediated by the Second Ankyrin Repeat: the IκBα Ankyrin Repeats Define a Novel Class of cis-Acting Nuclear Import Sequences

1998 • 142 citations

Characterization of IκBα Nuclear Import Pathway

1999 • 116 citations

Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysis

1998 • 113 citations

Loss of IκBα-Mediated Control over Nuclear Import and DNA Binding Enables Oncogenic Activation of c-Rel

1998 • 47 citations

I kappa B-alpha-mediated inhibition of nuclear transport and DNA-binding by Rel proteins are separable functions: phosphorylation of C-terminal serine residues of I kappa B-alpha is specifically required for inhibition of DNA-binding.

1995 • 16 citations

Deleted Work

1955 • 0 citations