Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Isolation of a protein that is essential for the first step of nuclear protein import

1994 • 710 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

1995 • 430 citations

Nopp 140 shuttles on tracks between nucleolus and cytoplasm

1992 • 409 citations

GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more

1995 • 394 citations

Purification of a Ran-interacting protein that is required for protein import into the nucleus.

1994 • 318 citations

A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm

1993 • 308 citations

Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope.

1994 • 306 citations

Pores for thought: nuclear pore complex proteins

1994 • 286 citations

The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors

1992 • 278 citations

Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

1993 • 261 citations

Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.

1995 • 254 citations

The human CAN protein, a putative oncogene productassociated with myeloid leukemogenesis, is a nuclear pore complex protein thatfaces the cytoplasm.

1994 • 238 citations

RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.

1994 • 176 citations

Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein.

1994 • 169 citations

NPI-1, the human homolog of SRP-1, Interacts with influenza virus nucleoprotein

1995 • 156 citations

Protein export from the nucleus requires the GTPase Ran and GTP hydrolysis.

1995 • 65 citations

Isolation of cDNA coding for the placental protein 15 (PP15)

1988 • 17 citations