Resolving a Fidelity Paradox

Enzyme structure and mechanism

1977 • 2,935 citations

Enzyme structure and mechanism

1978 • 2,897 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp

1992 • 748 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

Enzymatic Synthesis of Deoxyribonucleic Acid

1972 • 594 citations

Enzyme structure and mechanism (2nd edn)

1985 • 484 citations

All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis

2000 • 399 citations

Studies on the Biochemical Basis of Spontaneous Mutation

1972 • 340 citations

DNA polymerase insertion fidelity. Gel assay for site-specific kinetics.

1987 • 332 citations

DNA Polymerase II

1970 • 330 citations

SOS Mutator DNA Polymerase IV Functions in Adaptive Mutation and Not Adaptive Amplification

2001 • 300 citations

Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase.

1990 • 293 citations

Mutagenesis by transient misalignment.

1988 • 265 citations

Nearest Neighbor Influences on DNA Polymerase Insertion Fidelity

1989 • 247 citations

DNA Polymerase III Holoenzyme Of Escherichia Coli

1988 • 185 citations

Frameshift mutagenesis by eucaryotic DNA polymerases in vitro.

1986 • 177 citations

Studies on the biochemical basis of spontaneous mutation

1974 • 170 citations

Error induction and correction by mutant and wild type T4 DNA polymerases. Kinetic error discrimination mechanisms.

1979 • 167 citations

Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation.

1979 • 165 citations

Abasic Translesion Synthesis by DNA Polymerase β Violates the “A-rule”

1997 • 163 citations

A phenotype for enigmatic DNA polymerase II: A pivotal role for pol II in replication restart in UV-irradiated Escherichia coli

1999 • 152 citations

Assembly of a Chromosomal Replication Machine: Two DNA Polymerases, a Clamp Loader, and Sliding Clamps in One Holoenzyme Particle. I. ORGANIZATION OF THE CLAMP LOADER

1995 • 130 citations

DNA polymerase II is encoded by the DNA damage-inducible dinA gene of Escherichia coli.

1990 • 129 citations

Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins.

1992 • 126 citations

DNA Polymerase Fidelity: From Genetics Toward a Biochemical Understanding

1998 • 121 citations

Fidelity of Escherichia coli DNA Polymerase III Holoenzyme

1997 • 120 citations

Adaptive Mutation in Escherichia coli

2000 • 108 citations

Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli.

1995 • 106 citations

Pre-Steady-State Kinetic Analysis of Sequence-Dependent Nucleotide Excision by the 3'-Exonuclease Activity of Bacteriophage T4 DNA Polymerase

1994 • 99 citations

Influence of neighboring bases on DNA polymerase insertion and proofreading fidelity.

1985 • 98 citations

The Escherichia coli polB gene, which encodes DNA polymerase II, is regulated by the SOS system

1990 • 95 citations

Enzymatic determinants of DNA polymerase accuracy. Theory of coliphage T4 polymerase mechanisms

1978 • 90 citations

Influence of 5'-nearest neighbors on the insertion kinetics of the fluorescent nucleotide analog 2-aminopurine by Klenow fragment

1993 • 86 citations

Base mispair extension kinetics. Binding of avian myeloblastosis reverse transcriptase to matched and mismatched base pair termini.

1992 • 81 citations

Studies on the biochemical basis of spontaneous mutation

1977 • 76 citations

Gel Kinetic Analysis of DNA Polymerase Fidelity in the Presence of Proofreading Using Bacteriophage T4 DNA Polymerase

1995 • 73 citations

Kinetic Analysis of Base Substitution Mutagenesis by Transient Misalignment of DNA and by Miscoding

1989 • 70 citations

Dynamics of Loading the β Sliding Clamp of DNA Polymerase III onto DNA

1996 • 59 citations

DNA polymerase II of Escherichia coli in the bypass of abasic sites in vivo.

1994 • 52 citations

The half-of-the-sites reactivity of horse liver alcohol dehydrogenase in the presence of alcohol substrates

1974 • 44 citations

Influence of local nucleotide sequence on substitution of 2-aminopurine for adenine during deoxyribonucleic acid synthesis in vitro

1983 • 39 citations

[2] Purification and properties of DNA polymerase II from Escherichia coli

1995 • 29 citations

Appendix

1997 • 15 citations