Structure of the Replicating Complex of a Pol α Family DNA Polymerase

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

1998 • 1,420 citations

SMART: a web-based tool for the study of genetically mobile domains

2000 • 1,298 citations

A constant rate of spontaneous mutation in DNA-based microbes.

1991 • 1,194 citations

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

1998 • 1,164 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

1993 • 1,097 citations

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

Physiological Studies of Conditional Lethal Mutants of Bacteriophage T4D

1963 • 808 citations

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP.

1994 • 694 citations

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation

1998 • 682 citations

An attempt to unify the structure of polymerases

1990 • 640 citations

Crystal Structures of Human DNA Polymerase β Complexed with Gapped and Nicked DNA: Evidence for an Induced Fit Mechanism^,

1997 • 601 citations

Compilation, alignment, and phylogenetic relationships of DNA polymerases

1993 • 590 citations

Structures of Ternary Complexes of Rat DNA Polymerase β, a DNA Template-Primer, and ddCTP

1994 • 587 citations

CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY

1993 • 558 citations

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

1998 • 520 citations

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

1991 • 495 citations

Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA

1993 • 473 citations

Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69

1997 • 431 citations

Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes

1998 • 375 citations

Torsion angle dynamics: Reduced variable conformational sampling enhances crystallographic structure refinement

1994 • 369 citations

Building a Replisome from Interacting Pieces

1999 • 368 citations

An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics

1991 • 364 citations

Kinetic mechanism of DNA polymerase I (Klenow)

1987 • 352 citations

Structure of Taq polymerase with DNA at the polymerase active site

1996 • 322 citations

An open and closed case for all polymerases

1999 • 310 citations

DNA- and RNA-dependent DNA polymerases

1993 • 218 citations

Kinetic mechanism of DNA polymerase I(Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant

1991 • 218 citations

Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius

1999 • 208 citations

Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction

1991 • 208 citations

Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4

1992 • 207 citations

A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides

1998 • 198 citations

Conferring RNA polymerase Activity to a DNA polymerase: A single residue in reverse transcriptase controls substrate selection

1997 • 184 citations

The structure of guanosine-thymidine mismatches in B-DNA at 2.5-A resolution.

1987 • 177 citations

Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate

1993 • 175 citations

Crystal structure of a pol α family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp . 9°N-7 1 1Edited by D. Rees

2000 • 139 citations

Calculation of an OMIT map

1988 • 135 citations

Side Chains That Influence Fidelity at the Polymerase Active Site of Escherichia coli DNA Polymerase I (Klenow Fragment)

1999 • 129 citations

The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase

1995 • 128 citations

Determinants of nucleotide sugar recognition in an archaeon DNA polymerase

1999 • 110 citations

DNA substrate structural requirements for the exonuclease and polymerase activities of prokaryotic and phage DNA polymerases

1989 • 101 citations

Mutational analysis of the human DNA polymerase alpha. The most conserved region in alpha-like DNA polymerases is involved in metal-specific catalysis

1993 • 99 citations

Replication of non-hydrogen bonded bases by DNA polymerases: A mechanism for steric matching

1998 • 97 citations

Crystal structure of an archaebacterial DNA polymerase

1999 • 94 citations

Modular Organization of T4 DNA Polymerase

1995 • 93 citations

A single tyrosine prevents insertion of ribonucleotides in the eukaryotic-type φ29 DNA polymerase 1 1Edited by A. R. Fersht

1999 • 89 citations

Dynamics of Bacteriophage T4 DNA Polymerase Function: Identification of Amino Acid Residues that Affect Switching between Polymerase and 3′ → 5′ Exonuclease Activities

1995 • 82 citations

Autogenous translational operator recognized by bacteriophage T4 DNA polymerase

1990 • 79 citations

Primer Terminus Stabilization at the φ29 DNA Polymerase Active Site

1995 • 78 citations

Structural features and hydration of a dodecamer duplex containing two C.A mispairs

1987 • 60 citations

Structure of an RNA Internal Loop Consisting of Tandem C-A⁺ Base Pairs^,

1998 • 59 citations

The carboxyl terminus of the bacteriophage T4 DNA polymerase is required for holoenzyme complex formation

1996 • 51 citations

Kinetic mechanism of DNA polymerase I

1987 • 43 citations

DNA polymerase of the T4-related bacteriophages

2000 • 43 citations

Steady-State Kinetic Characterization of RB69 DNA Polymerase Mutants Τhat Affect dNTP Incorporation

1999 • 42 citations

Crystal Structure of an RNA 16-mer Duplex R(GCAGAGUUAAAUCUGC)₂ with Nonadjacent G(Syn)·A⁺(Anti) Mispairs

1999 • 40 citations

Locations of amino acid substitutions in bacteriophage T4 tsL56 DNA polymerase predict an N-terminal exonuclease domain

1989 • 32 citations

Isolation, characterization, and kinetic properties of truncated forms of T4 DNA polymerase that exhibit 3‘-5‘ exonuclease activity.

1994 • 31 citations

A Novel Kinetic Analysis to Calculate Nucleotide Affinity of Proofreading DNA Polymerases:

1995 • 25 citations

Retention of replication fidelity by a DNA polymerase functioning in a distantly related environment

1997 • 23 citations

Role of the first aspartate residue of the “YxDTDS” motif of ø29 DNA polymerase as a metal ligand during both TP-primed and DNA-primed DNA synthesis

1998 • 21 citations

Kinetic Characterization of a Bacteriophage T4 Antimutator DNA Polymerase

1998 • 19 citations

Genetic Mapping of the Amino-Terminal Domain of Bacteriophage T4 DNA Polymerase

1987 • 19 citations

Sequence analysis of the 17,166 base-pair EcoRI fragment C of B95-8 Epstein-Barr virus.

1983 • 17 citations

Nucleotide-sequence-specific and non-specific interactions of T4 DNA polymerase with its own mRNA

2000 • 17 citations