Building a Replisome from Interacting Pieces

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

1998 • 1,164 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

1994 • 899 citations

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

RIBBONS 2.0

1991 • 814 citations

Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA

1996 • 790 citations

Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp

1992 • 748 citations

FUNCTION AND STRUCTURE RELATIONSHIPS IN DNA POLYMERASES

1994 • 611 citations

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

1998 • 520 citations

Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA

1993 • 473 citations

Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69

1997 • 431 citations

Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme

1991 • 420 citations

Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes

1998 • 375 citations

Polymerases and the Replisome: Machines within Machines

1998 • 350 citations

DNA Polymerase II

1970 • 330 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

Structure of Taq polymerase with DNA at the polymerase active site

1996 • 322 citations

Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA

1995 • 246 citations

Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction

1991 • 208 citations

Structural and functional similarities of prokaryotic and eukaryotic DNA polymerase sliding clamps

1995 • 173 citations

DNA polymerase I: from crystal structure to function via genetics

1987 • 138 citations

Affinity purification of bacteriophage T4 proteins essential for DNA replication and genetic recombination.

1983 • 134 citations

How DNA Travels between the Separate Polymerase and 3′-5′-Exonuclease Sites of DNA Polymerase I (Klenow Fragment)

1989 • 129 citations

Purification of the gene 43, 44, 45, and 62 proteins of the bacteriophage T4 DNA replication apparatus.

1979 • 124 citations

DNA substrate structural requirements for the exonuclease and polymerase activities of prokaryotic and phage DNA polymerases

1989 • 101 citations

Structural and Enzymatic Studies of the T4 DNA Replication System

1989 • 95 citations

Protein‐protein interactions at a DNA replication fork: bacteriophage T4 as a model

1992 • 93 citations

Modular Organization of T4 DNA Polymerase

1995 • 93 citations

Dynamics of Bacteriophage T4 DNA Polymerase Function: Identification of Amino Acid Residues that Affect Switching between Polymerase and 3′ → 5′ Exonuclease Activities

1995 • 82 citations

An RNA Polymerase-Binding Protein That Is Required for Communication Between an Enhancer and a Promoter

1990 • 69 citations

The Influence of the Proliferating Cell Nuclear Antigen-interacting Domain of p21 on DNA Synthesis Catalyzed by the Human and Saccharomyces cerevisiae Polymerase δ Holoenzymes

1997 • 57 citations

Assembly of a functional replication complex without ATP hydrolysis: a direct interaction of bacteriophage T4 gp45 with T4 DNA polymerase.

1993 • 54 citations

Fidelity studies of the human DNA polymerase alpha. The most conserved region among alpha-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis

1993 • 53 citations

The carboxyl terminus of the bacteriophage T4 DNA polymerase is required for holoenzyme complex formation

1996 • 51 citations

A single mutation in bacteriophage T4 DNA polymerase (A737V, tsL141) decreases its processivity as a polymerase and increases its processivity as a 3‘–>5‘ exonuclease.

1994 • 46 citations

Identification of a transient excision intermediate at the crossroads between DNA polymerase extension and proofreading pathways

1998 • 42 citations

Divergence of a DNA Replication Gene Cluster in the T4-Related Bacteriophage RB69

1998 • 41 citations

The Proofreading Pathway of Bacteriophage T4 DNA Polymerase

1998 • 40 citations

Rapid assembly of the bacteriophage T4 core replication complex on a linear primer/template construct.

1993 • 37 citations

Clamp Subunit Dissociation Dictates Bacteriophage T4 DNA Polymerase Holoenzyme Disassembly

1998 • 33 citations

Mutagenesis of conserved region I in the DNA polymerase from human adenovirus serotype 2

1991 • 33 citations

Isolation, characterization, and kinetic properties of truncated forms of T4 DNA polymerase that exhibit 3‘-5‘ exonuclease activity.

1994 • 31 citations

Phase Improvement by Multi-Start Simulated Annealing Refinement and Structure-Factor Averaging

1998 • 30 citations

Bacteriophage T4 gene 45. Sequences of the structural gene and its protein product.

1982 • 28 citations

Site-directed mutagenesis of the YCDTDS amino acid motif of the Φ29 DNA polymerase

1990 • 27 citations

Kinetic Characterization of a Bacteriophage T4 Antimutator DNA Polymerase

1998 • 19 citations

Spatial relationship between polymerase and exonuclease active sites of phage T4 DNA polymerase enzyme.

1994 • 13 citations

The COOH-terminal Domain of the RNA Polymerase α Subunit in Transcriptional Enhancement and Deactivation at the Bacteriophage T4 Late Promoter

1995 • 13 citations

Residues at the Carboxy Terminus of T₄ DNA Polymerase Are Important Determinants for Interaction with the Polymerase Accessory Proteins

1997 • 11 citations