Fidelity and Error Specificity of the α Catalytic Subunit of Escherichia coli DNA Polymerase III

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

High efficiency transformation of E.coli by high voltage electroporation

1988 • 2,789 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

A constant rate of spontaneous mutation in DNA-based microbes.

1991 • 1,194 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase

1988 • 814 citations

DNA replication, 2nd edn

1992 • 582 citations

Sequence of the lacI gene

1978 • 463 citations

DNA POLYMERASE III HOLOENZYME: Structure and Function of a Chromosomal Replicating Machine

1995 • 422 citations

The CTAB-DNA precipitation method: a common mini-scale preparation of template DNA from phagemids, phages or plasmids suitable for sequencing.

1989 • 414 citations

DNA polymerase insertion fidelity. Gel assay for site-specific kinetics.

1987 • 332 citations

The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations.

1985 • 317 citations

Specificity and Mechanism of Error-prone Replication by Human Immunodeficiency Virus-1 Reverse Transcriptase

1989 • 316 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

Mechanisms of spontaneous mutagenesis: An analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene

1986 • 305 citations

The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation.

1986 • 301 citations

Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli.

1993 • 300 citations

Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase.

1990 • 293 citations

MECHANISMS OF SPONTANEOUS AND INDUCED FRAMESHIFT MUTATION IN BACTERIOPHAGE T4

1985 • 292 citations

Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors.

1987 • 291 citations

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

1988 • 278 citations

A separate editing exonuclease for DNA replication: the epsilon subunit of Escherichia coli DNA polymerase III holoenzyme.

1984 • 246 citations

Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction

1991 • 208 citations

Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4

1992 • 207 citations

Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair.

1988 • 203 citations

Spontaneous mutation in the Escherichia coli lacI gene.

1991 • 200 citations

Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro.

1989 • 189 citations

DNA Polymerase III Holoenzyme Of Escherichia Coli

1988 • 185 citations

Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots

1993 • 180 citations

The mutational specificity of DNA polymerases-alpha and -gamma during in vitro DNA synthesis.

1985 • 176 citations

Mutator strains of Escherichia coli, mutD and dnaQ, with defective exonucleolytic editing by DNA polymerase III holoenzyme.

1983 • 174 citations

The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I.

1990 • 169 citations

DNA Polymerase III holoenzyme of Escherichia coli. IV. The holoenzyme is an asymmetric dimer with twin active sites.

1988 • 168 citations

Exonucleolytic proofreading enhances the fidelity of DNA synthesis by chick embryo DNA polymerase-gamma.

1988 • 167 citations

The polymerase subunit of DNA polymerase III of Escherichia coli. II. Purification of the alpha subunit, devoid of nuclease activities.

1985 • 164 citations

Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastrophe.

1996 • 163 citations

Comparison of HIV-1 and avian myeloblastosis virus reverse transcriptase fidelity on RNA and DNA templates.

1992 • 145 citations

The effects of dNTP pool imbalances on frameshift fidelity during DNA replication.

1992 • 142 citations

Frameshift errors initiated by nucleotide misincorporation.

1990 • 136 citations

Proofreading by DNA polymerase III of Escherichia coli depends on cooperative interaction of the polymerase and exonuclease subunits.

1987 • 132 citations

Differential extension of 3′ mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-α

1989 • 129 citations

Fidelity of mammalian DNA replication and replicative DNA polymerases

1991 • 119 citations

Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit.

1994 • 108 citations

Rapid repeated cloning of mutant lac repressor genes

1985 • 101 citations

DNA polymerase accuracy and spontaneous mutation rates: frequencies of purine.purine, purine.pyrimidine, and pyrimidine.pyrimidine mismatches during DNA replication.

1981 • 91 citations

Transcription-repair coupling determines the strandedness of ultraviolet mutagenesis in Escherichia coli.

1992 • 83 citations

Fidelity of DNA polymerase I and the DNA polymerase I-DNA primase complex from Saccharomyces cerevisiae.

1989 • 77 citations

Purification and Properties of Wild-type and Exonuclease-deficient DNA Polymerase II from Escherichia coli

1995 • 73 citations

Reactions at the polymerase active site that contribute to the fidelity of Escherichia coli DNA polymerase I (Klenow fragment).

1992 • 73 citations

Kinetic Analysis of Base Substitution Mutagenesis by Transient Misalignment of DNA and by Miscoding

1989 • 70 citations

The fidelity of base selection by the polymerase subunit of DNA polymerase III holoenzyme

1988 • 64 citations

A strong mutator effect caused by an amino acid change in the alpha subunit of DNA polymerase III of Escherichia coli.

1991 • 48 citations

The mutational specificity of two Escherichia coli dnaE antimutator alleles as determined from lacI mutation spectra.

1993 • 40 citations

Spontaneous mutation in Escherichia coli containing the dnaE911 DNA polymerase antimutator allele.

1994 • 33 citations

Mutations produced by DNA polymerase III holoenzyme of Escherichia coli after in vitro synthesis in the absence of single‐strand binding protein

1990 • 8 citations