Of Extracellular Matrix, Scaffolds, and Signaling: Tissue Architecture Regulates Development, Homeostasis, and Cancer

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

2017 • 5,610 citations

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

Tensional homeostasis and the malignant phenotype

2005 • 3,655 citations

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

1997 • 1,572 citations

How does the extracellular matrix direct gene expression?

1982 • 1,475 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

Molecular characterization of the tumor microenvironment in breast cancer

2004 • 1,278 citations

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

2005 • 1,225 citations

Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

1996 • 1,206 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

1975 • 1,175 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

1992 • 1,047 citations

Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice.

1959 • 985 citations

The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

1999 • 916 citations

Plasticity of the Differentiated State

1985 • 839 citations

über Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren

1924 • 817 citations

The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

2002 • 763 citations

Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

2005 • 714 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

1991 • 659 citations

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

1977 • 641 citations

Sensory Nerves Determine the Pattern of Arterial Differentiation and Blood Vessel Branching in the Skin

2002 • 635 citations

Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells

1997 • 633 citations

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

1998 • 625 citations

Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas

1996 • 583 citations

Aging and Genome Maintenance: Lessons from the Mouse?

2003 • 556 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

2000 • 537 citations

Distinct epigenetic changes in the stromal cells of breast cancers

2005 • 510 citations

Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

2002 • 486 citations

Information networks in the mammary gland

2005 • 486 citations

Hormonal, cellular, and molecular control of prostatic development

2003 • 468 citations

Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.

1994 • 466 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

2003 • 433 citations

über Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren

1924 • 429 citations

Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.

1990 • 417 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

1994 • 405 citations

Patterning Mechanisms Controlling Vertebrate Limb Development

2001 • 403 citations

Laminin mediates tissue-specific gene expression in mammary epithelia.

1995 • 397 citations

A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression

1995 • 378 citations

The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells

2001 • 373 citations

Mammary gland development and tumorigenesis in estrogen receptor knockout mice.

1997 • 354 citations

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes

2003 • 351 citations

Mesenchyme-Dependent Morphogenesis and Epithelium-Specific Cytodifferentiation in Mouse Mammary Gland

1976 • 348 citations

Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation

2005 • 335 citations

Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse

1969 • 327 citations

Tumor reversion: Correction of malignant behavior by microenvironmental cues

2003 • 321 citations

β1 Integrin Inhibitory Antibody Induces Apoptosis of Breast Cancer Cells, Inhibits Growth, and Distinguishes Malignant from Normal Phenotype in Three Dimensional Cultures and In vivo

2006 • 314 citations

Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrata.

1984 • 314 citations

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.

1995 • 304 citations

Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells.

1995 • 301 citations

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis

2003 • 293 citations

Establishing a framework for the functional mammary gland: from endocrinology to morphology.

2002 • 292 citations

Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

2005 • 291 citations

Regionally specific induction by the Spemann–Mangold organizer

2004 • 286 citations

Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor.

1991 • 284 citations

Microenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes

2005 • 280 citations

Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion.

1985 • 279 citations

Differentiation requires continuous regulation.

1991 • 276 citations

The production of new hydranths in Hydra by the insertion of small grafts

1909 • 274 citations

Phenotypic Reversion or Death of Cancer Cells by Altering Signaling Pathways in Three-Dimensional Contexts

2002 • 268 citations

Extracellular matrix regulates expression of the TGF-beta 1 gene.

1993 • 260 citations

Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development

1999 • 260 citations

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1993 • 260 citations

Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis

1996 • 256 citations

The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter

2000 • 255 citations

Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential.

1996 • 254 citations

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

2001 • 249 citations

Molecular Regulation of Lung Development

2001 • 244 citations

Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene.

1996 • 238 citations

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro

2004 • 238 citations

Myoepithelial cells: good fences make good neighbors

2005 • 237 citations

Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells

1995 • 231 citations

Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development

1991 • 228 citations

Über die Determination der ersten Organanlagen des Amphibienembryo I–VI

1918 • 228 citations

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation ¹

1997 • 227 citations

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

1993 • 224 citations

The mammary gland and its origin during synapsid evolution.

2002 • 223 citations

Tissue interactions and development

1973 • 223 citations

Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells

2004 • 220 citations

Extracellular matrix and hormones transcriptionally regulate bovine beta-casein 5' sequences in stably transfected mouse mammary cells.

1990 • 217 citations

Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants.

1997 • 216 citations

A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.

1995 • 216 citations

The Differentiated State of Normal and Malignant Cells or How to Define a “Normal” Cell in Culture

1981 • 208 citations

Mediation of Wound-Related Rous Sarcoma Virus Tumorigenesis by TGF-β

1990 • 203 citations

Cellular growth and survival are mediated by β1 integrins in normal human breast epithelium but not in breast carcinoma

1995 • 203 citations

Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development.

1995 • 194 citations

Control of Integrin Expression by Extracellular Matrix

1995 • 190 citations

A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of beta-casein gene expression.

1992 • 187 citations

Tissue interactions mediate early events in pulmonary vasculogenesis

2000 • 184 citations

Epithelial–stromal interactions in the mouse and human mammary gland in vivo

2004 • 183 citations

Ectopic TGFβ1 Expression in the Secretory Mammary Epithelium Induces Early Senescence of the Epithelial Stem Cell Population

1995 • 182 citations

Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture

1991 • 181 citations

Molecular “Vitalism”

2000 • 173 citations

Transforming growth factor β3 induces cell death during the first stage of mammary gland involution

2000 • 173 citations

HGF/SF: a potent cytokine for mammary growth, morphogenesis and development

1995 • 171 citations

Dystroglycan is required for polarizing the epithelial cells and the oocyte inDrosophila

2002 • 168 citations

CEACAM1-4S, a cell–cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture

2003 • 168 citations

Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro.

1991 • 167 citations

Stat5 as a Target for Regulation by Extracellular Matrix

1995 • 154 citations

Expression of Autoactivated Stromelysin-1 in Mammary Glands of Transgenic Mice Leads to a Reactive Stroma During Early Development

1998 • 152 citations

Reprogramming cell differentiation in the absence of DNA synthesis

1984 • 149 citations

ERK and MMPs Sequentially Regulate Distinct Stages of Epithelial Tubule Development

2004 • 149 citations

Do different branching epithelia use a conserved developmental mechanism?

2002 • 148 citations

Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis.

1998 • 145 citations

Epimorphin Functions as a Key Morphoregulator for Mammary Epithelial Cells

1998 • 143 citations

The Organization of Tight Junctions in Epithelia: Implications for Mammary Gland Biology and Breast Tumorigenesis

2003 • 143 citations

The development of a functionally relevant cell culture model of progressive human breast cancer

1995 • 133 citations

Reconstitution of Mammary Gland Development In Vitro: Requirement of c-met and c-erbB2 Signaling for Branching and Alveolar Morphogenesis

1998 • 131 citations

Breast Cancer: Induction of Differentiation by Embryonic Tissue

1973 • 130 citations

Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation

2003 • 129 citations

Notch4 and Wnt-1 Proteins Function to Regulate Branching Morphogenesis of Mammary Epithelial Cells in an Opposing Fashion

1998 • 126 citations

The influence of embryonic mesoderm on the regional specification of epidermal derivatives in the chick

1954 • 125 citations

Prolactin-mediated gene activation in mammary epithelial cells

1995 • 125 citations

Growth of Mouse Mammary Glands in vivo after Monolayer Culture

1965 • 123 citations

Effect of stromal and epithelial cells derived from normal and tumorous breast tissue on the proliferation of human breast cancer cell lines in co-culture

1997 • 122 citations

Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo

1991 • 120 citations

Targeted Expression of a Dominant Negative Epidermal Growth Factor Receptor in the Mammary Gland of Transgenic Mice Inhibits Pubertal Mammary Duct Development

1997 • 119 citations

Division of Labor among the α6β4 Integrin, β1 Integrins, and an E3 Laminin Receptor to Signal Morphogenesis and β-Casein Expression in Mammary Epithelial Cells

1999 • 118 citations

The Extracellular Matrix in Epithelial Biology: Shared Molecules and Common Themes in Distant Phyla

1996 • 118 citations

Sequence and Comparative Genomic Analysis of Actin-related Proteins

2005 • 116 citations

Timp-1 Is Important for Epithelial Proliferation and Branching Morphogenesis during Mouse Mammary Development

1999 • 114 citations

Characterization of BCE-1, a Transcriptional Enhancer Regulated by Prolactin and Extracellular Matrix and Modulated by the State of Histone Acetylation

1998 • 102 citations

Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1

1995 • 100 citations

Recent genetic studies of mouse kidney development

2004 • 99 citations

Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases

1998 • 97 citations

Branching morphogenesis of the lung: new molecular insights into an old problem

2003 • 93 citations

Mammary Phenotypic Expression Induced in Epidermal Cells by Embryonic Mammary Mesenchyme

1995 • 87 citations

Estrogen Mediates Mammary Epithelial Cell Proliferation in Serum-Free Culture Indirectly via Mammary Stroma-Derived Hepatocyte Growth Factor

2002 • 87 citations

Epithelial morphogenesis in mouse embryonic submandibular gland: Its relationships to the tissue organization of epithelium and mesenchyme

1997 • 82 citations

Tweak induces mammary epithelial branching morphogenesis

2005 • 81 citations

Epithelial morphogenesis in hydra requires de novo expression of extracellular matrix components and matrix metalloproteinases

2002 • 81 citations

ECM-induced gap junctional communication enhances mammary epithelial cell differentiation

2003 • 79 citations

Early development of parasympathetic nerves in the mouse submandibular gland

1975 • 79 citations

Loss of Heterozygosity in Fibrocystic Change of the Breast

2000 • 78 citations

Functional Significance of MMP-9 in Tumor Necrosis Factor-Induced Proliferation and Branching Morphogenesis of Mammary Epithelial Cells*

2000 • 76 citations

Epimorphin Mediates Mammary Luminal Morphogenesis through Control of C/EBPβ

2001 • 72 citations

Influence of microenvironment on mammary epithelial cell survival in primary culture

1999 • 68 citations

Breast Development in Puberty

1986 • 67 citations

Metaplastic induction of scales and feathers in the corneal anterior epithelium of the chick embryo

1971 • 61 citations

Differential regulation of breast tumor cell proliferation by stromal fibroblasts of various breast tissue sources

1996 • 58 citations

The role of connexin-mediated cell-cell communication in breast cancer metastasis.

2001 • 57 citations

Extracellular Signals That Regulate Liver Transcription Factors during Hepatic Differentiation In Vitro

1991 • 55 citations

β-Casein Gene Promoter Activity Is Regulated by the Hormone- Mediated Relief of Transcriptional Repression and a MammaryGland-Specific Nuclear Factor

1991 • 52 citations

Epimorphin Overexpression in the Mouse Mammary Gland Promotes Alveolar Hyperplasia and Mammary Adenocarcinoma

2005 • 48 citations

Mouse models of transforming growth factor β impact in breast development and cancer

2005 • 46 citations

GENETIC ANALYSIS OF EXTRACELLULAR MATRIX IN C. ELEGANS

1994 • 46 citations

Prolactin and Transforming Growth Factor-β Signaling Exert Opposing Effects on Mammary Gland Morphogenesis, Involution, and the Akt-Forkhead Pathway

2004 • 45 citations

Endocrinology of the breast: Basic and clinical aspects

1986 • 43 citations

Structure and function of an early divergent form of laminin in hydra: a structurally conserved ECM component that is essential for epithelial morphogenesis

2002 • 39 citations

Synthesis and Secretion of Structural Macromolecules by Endothelial Cells in Culture

1982 • 38 citations

The Transforming Growth Factors Beta in Development and Functional Differentiation of the Mouse Mammary Gland

2001 • 37 citations

The origin of pattern and feather germ tract specificity

1957 • 35 citations

Pattern formation in epithelial development: the vertebrate limb and feather bud spacing

1998 • 35 citations

[The determination of specific differentiation of neoptile and teleoptile feathers in the chick and the duck].

1970 • 31 citations

Analyse des facteurs de la différenciation spécifique de la plume néoptile chez le Canard et le Poulet

1967 • 31 citations

Beiträge zur Entwickelungsgeschichte des Hühnchens im Eye

1817 • 28 citations

Transdifferentiation of embryonic and postnatal rabbit corneal epithelial cells

1994 • 28 citations

Regulation by the extracellular matrix (ECM) of prolactin‐induced αs1‐casein gene expression in rabbit primary mammary cells: Role of STAT5, C/EBP, and chromatin structure

2005 • 27 citations

Trichostatin a inhibits β‐casein expression in mammary epithelial cells

2001 • 24 citations

Targeted Expression of a Dominant Negative Epidermal Growth Factor Receptor in the Mammary Gland of Transgenic Mice Inhibits Pubertal Mammary Duct Development

1997 • 23 citations

Extracellular matrix family proteins that are potential targets of Dd-STATa in Dictyostelium discoideum

2004 • 21 citations

Functional Significance of MMP-9 in Tumor Necrosis Factor-Induced Proliferation and Branching Morphogenesis of Mammary Epithelial Cells

2000 • 15 citations

An extracellular matrix response element in the promoter of the LpS1 genes of the sea urchin Lytechinus pictus

1997 • 12 citations

Tissue Specificity: Structural Cues Allow Diverse Phenotypes from a Constant Genotype

2003 • 8 citations

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