Targeted Expression of a Dominant Negative Epidermal Growth Factor Receptor in the Mammary Gland of Transgenic Mice Inhibits Pubertal Mammary Duct Development

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Epidermal growth factor.

1990 • 1,645 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

1995 • 1,035 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.

1997 • 797 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 • 659 citations

Insights from the study of animals lacking functional estrogen receptor

1994 • 587 citations

Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family

1989 • 586 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

1994 • 432 citations

Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor

1990 • 415 citations

The Mammary gland : development, regulation, and function

1987 • 396 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

Growth Factors in Breast Cancer

1995 • 378 citations

Cross-Talk between Peptide Growth Factor and Estrogen Receptor Signaling Pathways

1998 • 334 citations

MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF

1985 • 332 citations

Endocrine Control of Mammary-Gland Development and Function in the C3H/He Crgl Mouse<xref ref-type="fn" rid="FN1">2</xref>

1958 • 281 citations

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1993 • 260 citations

Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

1995 • 247 citations

Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.

1993 • 240 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells.

1986 • 222 citations

A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.

1995 • 216 citations

TGF-β1-induced inhibition of mouse mammary ductal growth: Developmental specificity and characterization

1989 • 174 citations

Transmission distortion and mosaicism in an unusual transgenic mouse pedigree

1984 • 169 citations

Comparison of cloned rabbit and mouse β-globin genes showing strong evolutionary divergence of two homologous pairs of introns

1978 • 156 citations

Local effects of EGF, α‐TGF, and EGF‐like growth factors on lobuloalveolar development of the mouse mammary gland in vivo

1987 • 147 citations

Targeting of transforming growth factor-alpha expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas.

1995 • 133 citations

Cloning and Expression of cDNA Encoding Human Betacellulin, a New Member of the EGF Family

1993 • 133 citations

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.

1992 • 129 citations

Essential role of endogenous estrogen in directly stimulating mammary growth demonstrated by implants containing pure antiestrogens.

1994 • 128 citations

Cell-Type-Specific Expression of Transforming Growth Factor-α in the Mouse Uterus during the Peri-implantation Period1

1991 • 115 citations

Amplified and overexpressed epidermal growth factor receptor gene in uncultured primary human breast carcinoma.

1988 • 112 citations

Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.

1992 • 104 citations

EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain.

1991 • 100 citations

Cross talk between peptide growth factor and estrogen receptor signaling systems.

1995 • 96 citations

Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-alpha in mouse mammary epithelial cells: studies in culture and in transgenic mice.

1995 • 88 citations

α-Transforming Growth Factor in the Bovine Anterior Pituitary Gland: Secretion by Dispersed Cells and Immunohistochemical Localization*

1987 • 87 citations

Epidermal Growth Factor Receptor Levels in Mouse Mammary Glands in Various Physiological States*

1985 • 86 citations

Epidermal growth factor receptor synthesis is stimulated by phorbol ester and epidermal growth factor. Evidence for a common mechanism.

1987 • 76 citations

Estrogen induction of TGF-α is mediated by an estrogen response element composed of two imperfect palindromes

1996 • 73 citations

Regulation by Estrogen through the 5′-Flanking Region of the Transforming Growth Factor α Gene

1991 • 69 citations

Possible physiological role of epidermal growth factor in the development of the mouse mammary gland during pregnancy

1983 • 63 citations

Local Versus Systemically Mediated Effects of Estrogen on Normal Mammary Epithelial Cell Deoxyribonucleic Acid Synthesis*

1988 • 51 citations

Comparison of EGF receptor sequences as a guide to study the ligand binding site.

1991 • 46 citations

Impaired Insulin Signaling in Skeletal Muscles from Transgenic Mice Expressing Kinase-deficient Insulin Receptors

1995 • 35 citations

Inhibition of epidermal growth factor receptor aggregation by an antibody directed against the epidermal growth factor receptor extracellular domain.

1993 • 29 citations

Human immunodeficiency virus 1 Tat stimulates transcription of the transforming growth factor alpha gene in an epidermal growth factor-dependent manner.

1994 • 26 citations

Influence of Submandibular Salivary Glands on Hormone Responsiveness of Mouse Mammary Glands

1987 • 22 citations

Oncogene expression in mammary epithelial cells

1992 • 11 citations

Transforming Growth Factor Alpha and its Receptor in Human Mammary Epithelial Cells: Modulation of Epidermal Growth Factor Receptor Function with Oncogenic Transformation

1989 • 4 citations