Prolactin and Transforming Growth Factor-β Signaling Exert Opposing Effects on Mammary Gland Morphogenesis, Involution, and the Akt-Forkhead Pathway

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Transforming growth factor beta

2011 • 1,990 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

2002 • 703 citations

Transforming Growth Factor‐β

1990 • 696 citations

Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene

1997 • 647 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1998 • 531 citations

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

1991 • 279 citations

Interleukin-6 Inhibits Transforming Growth Factor-β-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt and Signal Transducers and Activators of Transcription 3 Pathways

1999 • 230 citations

TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G₁ arrest

2000 • 220 citations

Effect of Transforming Growth Factor-β¹on Proliferation and Death of Rat Prostatic Cells*

1990 • 218 citations

Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue

1997 • 217 citations

Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival

1999 • 214 citations

Ectopic TGFβ1 Expression in the Secretory Mammary Epithelium Induces Early Senescence of the Epithelial Stem Cell Population

1995 • 182 citations

Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture

1991 • 181 citations

Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells.

1994 • 180 citations

Transforming Growth Factor β Enhances Epithelial Cell Survival via Akt-dependent Regulation of FKHRL1

2001 • 178 citations

Prolactin Signaling in Mammary Gland Development

1997 • 174 citations

Transforming growth factor β3 induces cell death during the first stage of mammary gland involution

2000 • 173 citations

Mammary Gland Involution Is Delayed by Activated Akt in Transgenic Mice

2001 • 165 citations

Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP

2002 • 165 citations

Transforming growth factor beta 1 induces apoptotic cell death in cultured human gastric carcinoma cells.

1992 • 152 citations

Control of milk secretion and apoptosis during mammary involution.

1999 • 148 citations

Fyn Associates with Cbl and Phosphorylates Tyrosine 731 in Cbl, A Binding Site for Phosphatidylinositol 3-Kinase

1999 • 142 citations

Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation

2003 • 129 citations

The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy

2001 • 129 citations

Prolactin and mammary gland development.

1999 • 125 citations

Bcl-2 gene family and related proteins in mammary gland involution and breast cancer.

1999 • 116 citations

Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1

1992 • 114 citations

Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.

1998 • 113 citations

Prolactin Activates Tyrosyl Phosphorylation of Insulin Receptor Substrate 1 and Phosphatidylinositol-3-OH Kinase

1997 • 103 citations

Thrombopoietin Regulates Bcl-xL Gene Expression through Stat5 and Phosphatidylinositol 3-Kinase Activation Pathways

2002 • 99 citations

Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland

1999 • 96 citations

Prolactin Suppresses Glucocorticoid-Induced Thymocyte Apoptosis in Vivo

2003 • 86 citations

Transforming Growth Factor-β1 Stimulates Protein Kinase A in Mesangial Cells

1998 • 77 citations

Dysregulation of phosphatidylinositol 3‐kinase and downstream effectors in human breast cancer

2001 • 77 citations

Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15 (23):6541-6551

1997 • 76 citations

PRL Antiapoptotic Effect in the Rat Decidua Involves the PI3K/Protein Kinase B-Mediated Inhibition of Caspase-3 Activity

2001 • 71 citations

Prolactin-Regulated Apoptosis of Nb2 Lymphoma Cells: pim-1 , bcl-2 , and bax Expression

1998 • 64 citations

Differential expression of TGF-β isoforms during postlactational mammary gland involution

2000 • 45 citations

Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidylinositol 3-kinase activation in Nb2 cells

1997 • 44 citations

Characterization of apoptosis induced by transforming growth factor beta 1 in human hepatoma cells.

1994 • 42 citations

Possible role for protein kinase B in the anti-apoptotic effect of prolactin in rat Nb2 lymphoma cells

2000 • 29 citations

Prolactin signaling to pim-1 expression: a role for phosphatidylinositol 3-kinase

2001 • 24 citations

Perturbation of EGF-activated MEK1 and PKB signal pathways by TGF-?1 correlates with perturbation of EGF-induced cyclin D1 and DNA synthesis by TGF-?1 in C3H 10T1/2 cells

2000 • 11 citations

Roles of protein phosphatase 2A in IL-6 signal transduction in Hep3B cells

1998 • 8 citations

Attenuation and loss of hormonal modulation of KGF (FGF-7)/KGF receptor expression and mitogenesis during mammary tumor progression

2000 • 6 citations