Information networks in the mammary gland

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

1995 • 1,834 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice.

1959 • 985 citations

Multiple hormone interactions in the developmental biology of the mammary gland.

1980 • 866 citations

RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution

2002 • 802 citations

Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.

1997 • 797 citations

The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development

2000 • 731 citations

The Stat family in cytokine signaling

2001 • 723 citations

Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice

1999 • 710 citations

Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform

2000 • 693 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Suppressors of cytokine signaling and immunity

2003 • 607 citations

Cloning and expression of the rat prolactin receptor, a member of the growth hormone/prolactin receptor gene family

1988 • 564 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

1999 • 551 citations

An entire functional mammary gland may comprise the progeny from a single cell

1998 • 544 citations

Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

2003 • 534 citations

Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation

2004 • 491 citations

IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development

2001 • 469 citations

A paracrine role for the epithelial progesterone receptor in mammary gland development

1998 • 452 citations

Signaling Pathways in Mammary Gland Development

2001 • 396 citations

Stem cells and breast cancer: A field in transit

2003 • 370 citations

Prolactin Controls Mammary Gland Development via Direct and Indirect Mechanisms

1999 • 333 citations

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

2001 • 302 citations

The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study.

1968 • 276 citations

Think globally, act locally: the making of a mouse mammary gland

1998 • 269 citations

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

2001 • 268 citations

An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal

2002 • 264 citations

Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development

1999 • 260 citations

Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis

1996 • 256 citations

Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality

2003 • 252 citations

Involvement of estrogen receptor β in terminal differentiation of mammary gland epithelium

2002 • 247 citations

Impaired Alveologenesis and Maintenance of Secretory Mammary Epithelial Cells in Jak2 Conditional Knockout Mice

2004 • 239 citations

Prolactin, Growth Hormone, and Epidermal Growth Factor Activate Stat5 in Different Compartments of Mammary Tissue and Exert Different and Overlapping Developmental Effects

2001 • 232 citations

A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.

1995 • 216 citations

Regulation of Mammary Epithelial Cell Growth in Mice and Rats*

1990 • 211 citations

Induction of Mammary Gland Development in Estrogen Receptor-α Knockout Mice

2000 • 210 citations

SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

2003 • 201 citations

Galanin regulates prolactin release and lactotroph proliferation

1998 • 199 citations

A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland

2003 • 192 citations

Mammary Gland Development in Adult Mice Requires Epithelial and Stromal Estrogen Receptor α

2002 • 190 citations

Methods in Mammary Gland Biology and Breast Cancer Research

2000 • 176 citations

IGF-2 Is a Mediator of Prolactin-Induced Morphogenesis in the Breast

2002 • 168 citations

Impaired differentiation and lactational failure ofErbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5

2003 • 155 citations

A Novel LacZ Reporter Mouse Reveals Complex Regulation of the Progesterone Receptor Promoter During Mammary Gland Development

2002 • 146 citations

Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation

2005 • 143 citations

Prolactin involvement in breast cancer.

1999 • 136 citations

Receptor Activator of NF-κB Ligand Induction via Jak2 and Stat5a in Mammary Epithelial Cells

2003 • 123 citations

Deletion of Stat3 Blocks Mammary Gland Involution and Extends Functional Competence of the Secretory Epithelium in the Absence of Lactogenic Stimuli

2002 • 121 citations

Comparison of the Regulation of the Whey Acidic Protein Gene with that of a Hybrid Gene Containing the Whey Acidic Protein Gene Promoter in Transgenic Mice

1988 • 121 citations

Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation

1999 • 119 citations

Investigation of the Transcriptional Changes Underlying Functional Defects in the Mammary Glands of Prolactin Receptor Knockout Mice

2003 • 111 citations

Caveolin-1-deficient Mice Show Accelerated Mammary Gland Development During Pregnancy, Premature Lactation, and Hyperactivation of the Jak-2/STAT5a Signaling Cascade

2002 • 110 citations

Disruption of Steroid and Prolactin Receptor Patterning in the Mammary Gland Correlates with a Block in Lobuloalveolar Development

2002 • 106 citations

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor–deficient mice

2001 • 98 citations

Beyond Herceptin and Gleevec

2003 • 96 citations

Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation

2001 • 83 citations

Jak2 Is an Essential Tyrosine Kinase Involved in Pregnancy-Mediated Development of Mammary Secretory Epithelium

2002 • 80 citations

Progesterone receptors in the mouse mammary duct: distribution and developmental regulation.

1996 • 76 citations

Prolactin Regulates Mammary Epithelial Cell Proliferation Via Autocrine/Paracrine Mechanism

2003 • 69 citations

Loss of Interleukin 6 Results in Delayed Mammary Gland Involution: A Possible Role for Mitogen-Activated Protein Kinase and Not Signal Transducer and Activator of Transcription 3

2002 • 63 citations

The Stat3/5 Locus Encodes Novel Endoplasmic Reticulum and Helicase-like Proteins That Are Preferentially Expressed in Normal and Neoplastic Mammary Tissue

2001 • 63 citations

A Short Form of the Prolactin (PRL) Receptor Is Able to Rescue Mammopoiesis in Heterozygous PRL Receptor Mice

2003 • 61 citations

Murine Progesterone Receptor Expression in Proliferating Mammary Epithelial Cells During Normal Pubertal Development and Adult Estrous Cycle: Association with ERα and ERβ Status

1999 • 54 citations

Mammary Gland Remodeling Depends on gp130 Signaling through Stat3 and MAPK

2004 • 54 citations

Mammary epithelial stem cells: transplantation and self‐renewal analysis

2003 • 52 citations

Proteotyping of Mammary Tissue from Transgenic and Gene Knockout Mice with Immunohistochemical Markers: a Tool To Define Developmental Lesions

2003 • 52 citations

Distal regulatory elements required for rat whey acidic protein gene expression in transgenic mice.

1994 • 51 citations

Regulation and Function of the Cytokine-Inducible SH-2 Domain Proteins, CIS and SOCS3, in Mammary Epithelial Cells

2002 • 48 citations

Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development

2004 • 41 citations

A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands

2004 • 39 citations

Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated β-catenin

2003 • 35 citations

The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium

2002 • 29 citations

Rescue of Mammary Epithelium of Early Lethal Phenotypes by Embryonic Mammary Gland Transplantation as Exemplified with Insulin Receptor Null Mice

2000 • 29 citations

An Ets site in the whey acidic protein gene promoter mediates transcriptional activation in the mammary gland of pregnant mice but is dispensable during lactation.

1995 • 27 citations

The Neuropeptide Galanin Augments Lobuloalveolar Development

2003 • 19 citations