Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention
Data up to Jan 2025
Total Citations Per Year
Abstract
References (85)
p53 Mutations in Human Cancers
1991 • 8,133 citations
Rising Incidence of Hepatocellular Carcinoma in the United States
1999 • 2,875 citations
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
1996 • 2,304 citations
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
1994 • 1,821 citations
The blood supply of neoplasms in the liver.
1954 • 1,280 citations
Oncogenic alterations of metabolism
1999 • 1,095 citations
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
2001 • 921 citations
Tumor Mitochondria and the Bioenergetics of Cancer Cells
2015 • 720 citations
Mitochondrial Binding of Hexokinase II Inhibits Bax-induced Cytochrome c Release and Apoptosis
2002 • 657 citations
Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria
1999 • 642 citations
A Phosphatase Associated with Metastasis of Colorectal Cancer
2001 • 641 citations
Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism
2001 • 521 citations
Prediction of survival in glioma patients by means of positron emission tomography
1985 • 407 citations
Regulatory Mechanisms in Carbohydrate Metabolism
1959 • 396 citations
Mitochondrial Hexokinase
1967 • 391 citations
High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase
1977 • 378 citations
Glucose Catabolism in Cancer Cells
2001 • 351 citations
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase
2001 • 338 citations
Epidemiology of Hepatocellular Carcinoma
2001 • 328 citations
Regulation Of Carbohydrate Metabolism
2018 • 316 citations
Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.
1988 • 313 citations
Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding.
1981 • 307 citations
The glycolysis and respiration of tumors
1961 • 285 citations
Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.
1997 • 244 citations
Glucose Catabolism in Cancer Cells.
1995 • 229 citations
Glucose Catabolism in Cancer Cells
1997 • 228 citations
Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture.
1972 • 227 citations
Mammalian hexokinases and their abnormal expression in cancer.
2000 • 224 citations
Rat glucokinase gene: structure and regulation by insulin.
1989 • 220 citations
Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexlycarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC
1986 • 210 citations
Contributions of glycolysis and oxidative phosphorylation to adenosine 5'-triphosphate production in AS-30D hepatoma cells.
1984 • 186 citations
Hexokinase II mRNA and gene structure, regulation by insulin, and evolution.
1993 • 181 citations
The Regulation of Carbohydrate Metabolism
1975 • 181 citations
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
1996 • 176 citations
Chemoembolization of Liver Tumor in a Rabbit Model: Assessment of Tumor Cell Death with Diffusion-Weighted MR Imaging and Histologic Analysis
2000 • 174 citations
COMPARATIVE BIOCHEMISTRY OF HEPATOMAS. III. CARBOHYDRATE ENZYMES IN LIVER TUMORS OF DIFFERENT GROWTH RATES.
1963 • 171 citations
Oxygen-regulated transcription factors and their role in pulmonary disease
2000 • 164 citations
The Amino Acid Sequence of Rat Liver Glucokinase Deduced from Cloned cDNA
1989 • 158 citations
Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location.
1983 • 145 citations
Viral pathogenesis of hepatocellular carcinoma in the United States
1993 • 135 citations
High resolution X-ray structure of yeast hexokinase, an allosteric protein exhibiting a non-symmetric arrangement of subunits
1976 • 121 citations
Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase.
1990 • 118 citations
Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line.
1988 • 113 citations
The structure of mammalian hexokinase-1
1998 • 111 citations
Complete amino acid sequence of rat brain hexokinase, deduced from the cloned cDNA, and proposed structure of a mammalian hexokinase.
1989 • 110 citations
Human hexokinase: Sequences of amino- and carboxyl-terminal halves are homologous
1988 • 100 citations
Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate 1 1Edited by I. A. Wilson
1998 • 97 citations
Alterations in Glucose Metabolism in Chick-Embryo Cells Transformed by Rous Sarcoma Virus: Intracellular Levels of Glycolytic Intermediates
1974 • 95 citations
Accomplishments in Cancer Research
1991 • 92 citations
Isolation and characterization of the discrete N- and C-terminal halves of rat brain hexokinase: Retention of full catalytic activity in the isolated C-terminal half
1989 • 90 citations
Complete amino acid sequence of the type II isozyme of rat hexokinase, deduced from the cloned cDNA: Comparison with a hexokinase from novikoff ascites tumor
1991 • 83 citations
Functional Organization of Mammalian Hexokinases: Both N- and C-Terminal Halves of the Rat Type II Isozyme Possess Catalytic Sites
1996 • 74 citations
Prognostic predictive value of 18F-fluorodeoxyglucose positron emission tomography for patients with pancreatic cancer
2001 • 74 citations
Glucokinase: structural analysis of a protein involved in susceptibility to diabetes.
1994 • 72 citations
Evidence for functional hexokinase compartmentation in rat skeletal muscle mitochondria.
1984 • 71 citations
An introduction to the isoenzymes of mammalian hexokinase types I-III
1997 • 62 citations
Structure/function relationships in hexokinase. Site-directed mutational analyses and characterization of overexpressed fragments implicate different functions for the N- and C-terminal halves of the enzyme.
1993 • 59 citations
Complete amino acid sequence of the type III isozyme of rat hexokinase, deduced from the cloned cDNA
1991 • 57 citations
Rat brain hexokinase: Location of the allosteric regulatory site in a structural domain at the N-terminus of the enzyme
1987 • 56 citations
Glucose catabolism in cancer cells: regulation of the type II hexokinase promoter by glucose and cyclic AMP
1996 • 55 citations
Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130
1991 • 51 citations
Kinetic characterization of hexokinase isoenzymes from glioma cells: Implications for FDG imaging of human brain tumors
2001 • 50 citations
Properties of particulate hexokinase of the Krebs-2 ascites tumor
1959 • 47 citations
Human pancreatic Beta-cell glucokinase: cDNA sequence and localization of the polymorphic gene to chromosome 7, band p 13
1992 • 43 citations
Hexokinase: The Direct Link between Mitochondrial and Glycolytic Reactions in Rapidly Growing Cancer Cells
1978 • 39 citations
Characterization of some glycolytic enzymes from human retina and retinoblastoma.
1982 • 37 citations
Evolution of the type II hexokinase gene by duplication and fusion of the glucokinase gene with conservation of its organization.
1993 • 34 citations
Cell Growth and Oncogenesis
2012 • 32 citations
Human hexokinase II: localization of the polymorphic gene to chromosome 2
1993 • 28 citations
Stability of hexokinase II in Vitro and in ascites tumor cells
1982 • 27 citations
Characterization of hexokinase isoenzyme types I and II in ascites tumor cells by an interaction with mitochondrial membrane
1982 • 27 citations
Evidence that transcription of the hexokinase gene is increased in a rapidly growing rat hepatoma
1985 • 26 citations
A 2-cM genetic linkage map of human chromosome 7p that includes 47 loci
1992 • 22 citations
Gene Duplication in the Evolution of the Yeast Hexokinase Active Site
1979 • 21 citations
The Role of Mitochondrial Hexokinase Binding in the Abnormal Energy Metabolism of Tumor Cell Lines
1986 • 19 citations
Sequence of Human Hexokinase III cDNA and Assignment of the Human Hexokinase III Gene (HK3) to Chromosome Band 5q35.2 by Fluorescencein SituHybridization
1996 • 18 citations
Isoenzyme pattern and subcellular localization of hexokinases in human breast cancer and nonpathological breast tissue
1984 • 18 citations
The Role of Mitochondrial Hexokinase Binding in the Abnormal Energy Metabolism of Tumor Cell Lines
1986 • 17 citations
The Human Gene for the Type III Isozyme of Hexokinase: Structure, Basal Promoter, and Evolution
2001 • 15 citations
Cell Growth and Oncogenesis
1998 • 14 citations
Isolation of the Promoter for Type I Hexokinase from Rat
1996 • 13 citations
Assignment of hexokinase types 1, 2, 3 (<i>Hk1, 2, </i><i>3</i>) and glucokinase (<i>Gck</i>) to rat chromosome band 20q11, 4q34, 17q12 and 14q21 respectively, by in situ hybridization
1997 • 12 citations
Hexokinase 'binding sites' of normal and tumoral human brain mitochondria.
2000 • 9 citations
Assignment of the hexokinase type 3 gene (HK3) to human chromosome band 5q35.3 by somatic cell hybrids and in situ hybridization
1996 • 8 citations
Regional Mapping of Hexokinase-1 within the Short Arm of Chromosome 10
1984 • 7 citations