Somatic Mitochondrial DNA Mutations in Neurofibromatosis Type 1-Associated Tumors

Sequence and organization of the human mitochondrial genome

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Mutation and Cancer: Statistical Study of Retinoblastoma

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Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

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A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies

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Somatic mutations of the mitochondrial genome in human colorectal tumours

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Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

2000 • 808 citations

MITOMAP: a human mitochondrial genome database--2004 update

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Epidemiology of neurofibromatosis type 1

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MITOMAP: a human mitochondrial genome database

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Mitochondrial DNA in human malignancy

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1993 • 384 citations

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

2001 • 292 citations

Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer.

2002 • 257 citations

Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates.

2001 • 245 citations

High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas.

2001 • 245 citations

Confirmation of a Double-Hit Model for the NF1Gene in Benign Neurofibromas

1997 • 239 citations

Mitochondrial DNA Alterations in Cancer

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Distribution of 13 truncating mutations in the neurofibromatosis 1 gene

1995 • 183 citations

Gross deletions of the neurofibromatosis type 1 (NF1) gene are predominantly of maternal origin and commonly associated with a learning disability, dysmorphic features and developmental delay

1998 • 179 citations

Loss ofNF1 allele in schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma

1999 • 148 citations

Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules

1993 • 140 citations

Hyperactive Ras as a therapeutic target in neurofibromatosis type 1

1999 • 133 citations

Rearrangements of Human Mitochondrial DNA (mtDNA): New Insights into the Regulation of mtDNA Copy Number and Gene Expression

2000 • 131 citations

High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples

2001 • 130 citations

Do NF1 gene deletions result in a characteristic phenotype?

1997 • 126 citations

Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes

1990 • 123 citations

Signal transduction via Ras.

1998 • 122 citations

Characterization of the somatic mutational spectrum of the neurofibromatosis type 1 ( NF1 ) gene in neurofibromatosis patients with benign and malignant tumors

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Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: segregation, maintenance and recombination dependent upon nuclear background

1997 • 101 citations

Detection of somatic mutations in the mitochondrial DNA control region of colorectal and gastric tumors by heteroduplex and single‐strand conformation analysis

1997 • 98 citations

Comprehensive Scanning of the Entire Mitochondrial Genome for Mutations

2002 • 94 citations

Detection of Mitochondrial DNA Mutations by Temporal Temperature Gradient Gel Electrophoresis

1999 • 93 citations

Detection of mitochondrial DNA mutations in the tumor and cerebrospinal fluid of medulloblastoma patients.

2003 • 86 citations

Progesterone receptor expression in neurofibromas.

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Mitochondrial DNA alteration in esophageal cancer

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Amplification of mitochondrial DNA in acute myeloid leukaemia

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Increase of skin O2 diffusion resistance with birthweight.

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Neurofibromatosis type 1: A model condition for the study of the molecular basis of variable expressivity in human disorders

1999 • 63 citations

SomaticNF1 mutation spectra in a family with neurofibromatosis type 1: Toward a theory of genetic modifiers

2003 • 62 citations

Neurofibromatosis type 1: A model condition for the study of the molecular basis of variable expressivity in human disorders

1999 • 55 citations

Mutational and Expression Analysis of theNF1Gene Argues Against a Role as Tumor Suppressor in Sporadic Pilocytic Astrocytomas

2002 • 55 citations

Neurofibromatosis type 1 and Ras-mediated signaling: filling in the GAPs

1995 • 55 citations

Diagnosis and management of neurofibromatosis type 1

2001 • 52 citations

Evidence for association of mitochondrial DNA sequence amplification and nuclear localization in human low-grade gliomas

1996 • 47 citations

Neurofibromin Colocalizes with Mitochondria in Cultured Cells

1997 • 32 citations

D-loop mutations in mitochondrial DNA: link with mitochondrial DNA depletion?

2002 • 29 citations

Single-cell PCR performed with neurofibroma Schwann cells reveals the presence of both alleles of the neurofibromatosis type 1 (NF1) gene

1995 • 12 citations

AMPLIFICATION OF MITOCHONDRIAL-DNA IN ACUTE MYELOID-LEUKEMIA

1994 • 3 citations