Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism?

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 • 828 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease

1997 • 469 citations

Mitochondrial DNA mutations and pathogenesis.

1997 • 427 citations

Mitochondrial DNA mutations in human disease

2001 • 414 citations

Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA

2001 • 413 citations

Mitochondrial respiratory chain disorders I: mitochondrial DNA defects

2000 • 364 citations

Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease

1992 • 354 citations

Random Intracellular Drift Explains the Clonal Expansion of Mitochondrial DNA Mutations with Age

2001 • 332 citations

The epidemiology of pathogenic mitochondrial DNA mutations

2000 • 323 citations

Progressive Increase of the Mutated Mitochondrial DNA Fraction in Kearns-Sayre Syndrome

1990 • 311 citations

Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle

1977 • 304 citations

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

2001 • 292 citations

What regulates mitochondrial DNA copy number in animal cells?

2001 • 289 citations

Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle

1998 • 285 citations

Relaxed Replication of mtDNA: A Model with Implications for the Expression of Disease

1999 • 199 citations

A new mtDNA mutation showing accumulation with time and restriction to skeletal muscle.

1997 • 199 citations

Relaxed and Stringent Genomes: Why Cytoplasmic Genes Don't Obey Mendel's Laws

1994 • 115 citations