Structure and Function of Natural Killer Cell Receptors: Multiple Molecular Solutions to Self, Nonself Discrimination

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

ESPript: analysis of multiple sequence alignments in PostScript.

1999 • 2,820 citations

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht

1999 • 1,932 citations

Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis

2001 • 1,728 citations

NK CELL RECEPTORS

1998 • 1,666 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Shape complementarity at protein–protein interfaces

1994 • 1,217 citations

ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

2001 • 1,190 citations

Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells

1998 • 1,134 citations

Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

2001 • 1,036 citations

The C‐type lectin superfamily in the immune system

1998 • 1,022 citations

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.

1996 • 1,010 citations

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

1999 • 1,006 citations

HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A

1998 • 998 citations

Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells

2001 • 961 citations

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

1995 • 959 citations

REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS

1999 • 947 citations

A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells

1997 • 933 citations

Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages

2000 • 864 citations

MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells

1992 • 805 citations

Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells

1999 • 758 citations

Biology of Animal Lectins

1993 • 752 citations

Cloning of Immunoglobulin-Superfamily Members Associated with HLA-C and HLA-B Recognition by Human Natural Killer Cells

1995 • 735 citations

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.

1985 • 734 citations

NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis

1998 • 719 citations

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by CD94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis

1998 • 706 citations

Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice

2000 • 694 citations

The Immunoglobulin Fold

1994 • 679 citations

Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

1996 • 625 citations

DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes

1996 • 599 citations

Crystallographic Evidence for Preformed Dimers of Erythropoietin Receptor Before Ligand Activation

1999 • 597 citations

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

1995 • 575 citations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

1990 • 549 citations

Structure of the Calcium-Dependent Lectin Domain from a Rat Mannose-Binding Protein Determined by MAD Phasing

1991 • 547 citations

Association of DAP12 with Activating CD94/NKG2C NK Cell Receptors

1998 • 528 citations

STRUCTURAL BASIS OF T CELL RECOGNITION

1999 • 518 citations

p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation

1997 • 518 citations

The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor.

1995 • 507 citations

Mouse CD94/NKG2A Is a Natural Killer Cell Receptor for the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule Qa-1b

1998 • 491 citations

The human major histocompatibility complex class Ib molecule HLA‐E binds signal sequence‐derived peptides with primary anchor residues at positions 2 and 9

1997 • 489 citations

Crystal structure of the complex between human CD8αα and HLA-A2

1997 • 471 citations

Identification of a Novel, Dendritic Cell-associated Molecule, Dectin-1, by Subtractive cDNA Cloning

2000 • 457 citations

HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

1993 • 455 citations

Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids

1998 • 438 citations

NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily

1999 • 437 citations

A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing

1997 • 426 citations

Direct Binding and Functional Transfer of NK Cell Inhibitory Receptors Reveal Novel Patterns of HLA-C Allotype Recognition

1998 • 426 citations

Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1.

1983 • 414 citations

2B4, the Natural Killer and T Cell Immunoglobulin Superfamily Surface Protein, Is a Ligand for CD48

1998 • 405 citations

The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II

1999 • 400 citations

Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand

2000 • 399 citations

The X-ray structure of a growth hormone–prolactin receptor complex

1994 • 390 citations

Complex structure of the activating immunoreceptor NKG2D and its MHC class I–like ligand MICA

2001 • 389 citations

Four A6-TCR/Peptide/HLA-A2 Structures that Generate Very Different T Cell Signals Are Nearly Identical

1999 • 366 citations

The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.

1996 • 365 citations

Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E

1999 • 355 citations

On guard—activating NK cell receptors

2001 • 350 citations

PECULIAR IMMUNOBIOLOGY OF BONE MARROW ALLOGRAFTS

1971 • 349 citations

A human killer inhibitory receptor specific for HLA-A1,2.

1996 • 347 citations

PECULIAR IMMUNOBIOLOGY OF BONE MARROW ALLOGRAFTS

1971 • 343 citations

Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules.

1996 • 340 citations

Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer

1995 • 338 citations

NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80.

1994 • 337 citations

A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

1997 • 327 citations

The genomic context of natural killer receptor extended gene families

2001 • 310 citations

Cutting Edge: Human 2B4, an Activating NK Cell Receptor, Recruits the Protein Tyrosine Phosphatase SHP-2 and the Adaptor Signaling Protein SAP

1999 • 308 citations

Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones

1995 • 308 citations

Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: Structural evidence for new stimulatory and inhibitory pathways

1997 • 298 citations

Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2

1992 • 295 citations

Inhibitory MHC class I receptors on NK cells and T cells

1996 • 288 citations

Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein

1985 • 287 citations

A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells.

1993 • 283 citations

Functional and biochemical analysis of CD16 antigen on natural killer cells and granulocytes.

1988 • 280 citations

Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1

2000 • 271 citations

Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1–HLA-Cw4 complex

2001 • 262 citations

Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand

1999 • 260 citations

Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells.

1997 • 260 citations

Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.

1987 • 259 citations

NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor

1997 • 252 citations

Rejection of bone marrow allografts by mice with severe combined immune deficiency (SCID). Evidence that natural killer cells can mediate the specificity of marrow graft rejection.

1987 • 242 citations

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

1989 • 241 citations

Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases

1998 • 236 citations

The Role of Ly49A and 5E6(Ly49C) Molecules in Hybrid Resistance Mediated by Murine Natural Killer Cells Against Normal T Cell Blasts

1996 • 234 citations

Structure of a Heterophilic Adhesion Complex between the Human CD2 and CD58 (LFA-3) Counterreceptors

1999 • 232 citations

Dap10 and Dap12 Form Distinct, but Functionally Cooperative, Receptor Complexes in Natural Killer Cells

2000 • 232 citations

A single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes.

1997 • 224 citations

CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta.

1991 • 219 citations

Identification and Molecular Cloning of P75/Airm1, a Novel Member of the Sialoadhesin Family That Functions as an Inhibitory Receptor in Human Natural Killer Cells

1999 • 217 citations

Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA‐Cw4 molecules

1997 • 216 citations

Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.

1996 • 210 citations

The Direct Binding of a p58 Killer Cell Inhibitory Receptor to Human Histocompatibility Leukocyte Antigen (HLA)-Cw4 Exhibits Peptide Selectivity

1997 • 208 citations

Molecular characterization of human CD94: A type II membrane glycoprotein related to the C‐type lectin superfamily

1995 • 207 citations

Structural Features Impose Tight Peptide Binding Specificity in the Nonclassical MHC Molecule HLA-E

1998 • 206 citations

A Functional Hot Spot for Antigen Recognition in a Superagonist TCR/MHC Complex

2000 • 204 citations

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes

1998 • 198 citations

Structural Basis of CD8 Coreceptor Function Revealed by Crystallographic Analysis of a Murine CD8αα Ectodomain Fragment in Complex with H-2Kb

1998 • 185 citations

Crystal Structure of the MHC Class I Homolog MIC-A, a γδ T Cell Ligand

1999 • 178 citations

Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type.

1993 • 178 citations

Specific Recognition of HLA-E, But Not Classical, HLA Class I Molecules by Soluble CD94/NKG2A and NK Cells

1999 • 172 citations

Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors

1997 • 168 citations

Phenotypic and cytokine analysis of human peripheral blood gamma delta T cells expressing NK cell receptors.

1997 • 164 citations

Gene Structure, Expression Pattern, and Biological Activity of Mouse Killer Cell Activating Receptor-associated Protein (KARAP)/DAP-12

1998 • 154 citations

cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6.

1991 • 153 citations

Biochemical Nature and Cellular Distribution of the Paired Immunoglobulin-like Receptors, PIR-A and PIR-B

1999 • 152 citations

Crystal Structure and Ligand Binding Properties of the D1D2 Region of the Inhibitory Receptor LIR-1 (ILT2)

2000 • 142 citations

Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells.

1996 • 142 citations

T cell clones expressing the natural killer cell‐related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function

1994 • 140 citations

CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells.

1997 • 140 citations

A murine T lymphocyte antigen belongs to a supergene family of type II integral membrane proteins.

1989 • 139 citations

Demonstration by class I gene transfer that reduced susceptibility of human cells to natural killer cell‐mediated lysis is inversely correlated with HLA class I antigen expression

1989 • 133 citations

Structure of CD94 Reveals a Novel C-Type Lectin Fold

1999 • 127 citations

The Solution Structure of Type II Antifreeze Protein Reveals a New Member of the Lectin Family

1998 • 123 citations

Kinetics of Interaction of HLA-C Ligands with Natural Killer Cell Inhibitory Receptors

1998 • 121 citations

Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection.

1996 • 120 citations

Host MHC class I molecules modulate in vivo expression of a NK cell receptor.

1994 • 119 citations

Collectin structure: A review

2000 • 118 citations

Analysis of Qa-1bPeptide Binding Specificity and the Capacity of Cd94/Nkg2a to Discriminate between Qa-1–Peptide Complexes

2000 • 117 citations

Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48.

1993 • 115 citations

Cutting Edge: KAP10, a Novel Transmembrane Adapter Protein Genetically Linked to DAP12 but with Unique Signaling Properties

1999 • 115 citations

Identification of a human member of the Ly-49 multigene family

1998 • 112 citations

Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2

1999 • 110 citations

Recognition of class I major histocompatibility complex molecules by Ly-49: specificities and domain interactions.

1996 • 102 citations

New nomenclature for MHC receptors

2001 • 100 citations

The Binding Site of NK Receptors on HLA-C Molecules

1997 • 98 citations

The structure of a tunicate C-type lectin from polyandrocarpa misakiensis complexed with d-galactose

1999 • 94 citations

The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand.

1996 • 94 citations

Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I

1999 • 94 citations

Crystal structure of coagulation factor IX-binding protein from habu snake venom at 2.6 å: implication of central loop swapping based on deletion in the linker region 1 1Edited by R. Huber

1999 • 93 citations

The Functional Binding Site for the C-Type Lectin–Like Natural Killer Cell Receptor Ly49a Spans Three Domains of Its Major Histocompatibility Complex Class I Ligand

2001 • 92 citations

Crystal structure of tetranectin, a trimeric plasminogen‐binding protein with an α‐helical coiled coil

1997 • 89 citations

Class I MHC-Binding Characteristics of the 129/J Ly49 Repertoire

2001 • 89 citations

Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule.

1996 • 88 citations

Crystal structure of the murine NK cell–activating receptor NKG2D at 1.95 Å

2001 • 87 citations

Qa-1b Binds Conserved Class I Leader Peptides Derived from Several Mammalian Species

1998 • 87 citations

Activating and Inhibitory NK Cell Receptors

1998 • 86 citations

Mannose Receptor and Scavenger Receptor: Two Macrophage Pattern Recognition Receptors with Diverse Functions in Tissue Homeostasis and Host Defense

2002 • 86 citations

Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation.

1996 • 86 citations

Crystal Structure of the C-type Lectin-like Domain from the Human Hematopoietic Cell Receptor CD69

2001 • 81 citations

The structure, organization, activation and plasticity of the erythropoietin receptor

1999 • 78 citations

CD44 triggering enhances human NK cell cytotoxic functions.

1994 • 75 citations

Crystal Structure of Human CD69: A C-Type Lectin-Like Activation Marker of Hematopoietic Cells^,

2000 • 68 citations

Interactions of TCRs with MHC-peptide complexes: a quantitative basis for mechanistic models

1997 • 66 citations

Biophysical studies of T-cell receptors and their ligands

1996 • 66 citations

Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices

1994 • 63 citations

Binding of a soluble p70 killer cell inhibitory receptor to HLA‐B*5101: Requirement for all three p70 immunoglobulin domains

1997 • 62 citations

Threonine 80 on HLA‐B27 confers protection against lysis by a group of natural killer clones

1996 • 60 citations

Interaction of the Low-Affinity Receptor CD23/FcεRII Lectin Domain with the Fcε3−4 Fragment of Human Immunoglobulin E

1997 • 58 citations

Evolution of natural killer cell receptors

2001 • 55 citations

Interaction between the Human NK Receptors and Their Ligands

2000 • 55 citations

Interaction of the NK Cell Inhibitory Receptor Ly49A with H-2Dd

1999 • 53 citations

Human natural killer cell inhibitory receptors bind to HLA class I molecules

1996 • 52 citations

A three-domain T cell receptor is biologically active and specifically stains cell surface MHC/peptide complexes.

1997 • 52 citations

Cloning of human DECTIN-1 , a novel C-type lectin-like receptor gene expressed on dendritic cells

2001 • 52 citations

Human inhibitory and activating Ig-like receptors which modulate the function of myeloid cells

2000 • 52 citations

Structure of Human Histocompatibility Leukocyte Antigen (Hla)-Cw4, a Ligand for the Kir2d Natural Killer Cell Inhibitory Receptor

1999 • 51 citations

DC-SIGN, a Dentritic Cell-Specific HIV-1 Receptor Present in Placenta That Infects T Cells In Trans—A Review

2001 • 49 citations

The Ice-Binding Site of Sea Raven Antifreeze Protein Is Distinct from the Carbohydrate-Binding Site of the Homologous C-Type Lectin

1998 • 47 citations

Structure and Function of the Macrophage Mannose Receptor

2001 • 43 citations

Paired Immunoglobulin-like Receptors of Activating and Inhibitory Types

1999 • 38 citations

ILT Receptors at the Interface Between Lymphoid and Myeloid Cells

2000 • 37 citations

Structure of the C-Type Lectin Carbohydrate Recognition Domain of Human Tetranectin

1998 • 35 citations

Cumulative Inhibition of NK Cells and T Cells Resulting from Engagement of Multiple Inhibitory Ly49 Receptors

2001 • 32 citations

HLA-E is the ligand for the natural killer cell CD94/NKG2 receptors

1998 • 31 citations

Expression analysis of new Ly49 genes: most transcripts of Ly49j lack the transmembrane domain

1999 • 30 citations

The leukocyte immunoglobulin-like receptors (LIRs): a new family of immune regulators

1999 • 28 citations

Mapping the Ligand of the NK Inhibitory Receptor Ly49A on Living Cells

2000 • 28 citations

Killer Cell Inhibitory Receptor Expression by T Cells

1998 • 25 citations

Opposing functions of activatory T-cell receptors and inhibitory NK-cell receptors on cytotoxic T cells

1996 • 25 citations

NK and CTL Recognition of a Single Chain H-2Dd Molecule: Distinct Sites of H-2Dd Interact with NK and TCR

1999 • 24 citations

NK cell receptors: Of missing sugar and missing self

2000 • 17 citations

HLA-Class l-Specific Inhibitory Receptors of NK Type on a Subset of Human T Cells

1996 • 13 citations