Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules.

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution

1991 • 1,079 citations

Empty MHC class I molecules come out in the cold

1990 • 933 citations

Cloning of Immunoglobulin-Superfamily Members Associated with HLA-C and HLA-B Recognition by Human Natural Killer Cells

1995 • 735 citations

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

1995 • 575 citations

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

1993 • 537 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor.

1995 • 507 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

1993 • 455 citations

Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.

1995 • 446 citations

NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80.

1994 • 337 citations

Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.

1995 • 309 citations

Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones

1995 • 308 citations

Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line.

1989 • 305 citations

Toxic Shock Syndrome Toxin-1 Complexed with a Class II Major Histocompatibility Molecule HLA-DR1

1994 • 300 citations

Generation of Allospecific Natural Killer Cells by Stimulation Across a Polymorphism of HLA-C

1993 • 241 citations

The enigma of the natural killer cell

1995 • 236 citations

Human Natural Killer Cells: Origin, Clonality, Specificity, and Receptors

1993 • 222 citations

Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones.

1995 • 216 citations

Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells

1995 • 180 citations

Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene.

1992 • 157 citations

Costimulatory signals are required for optimal proliferation of human natural killer cells.

1993 • 112 citations

Peptide-induced stabilization and intracellular localization of empty HLA class I complexes.

1992 • 91 citations

Recognition of major histocompatibility complex class I antigens by natural killer cells.

1994 • 84 citations

Tyrosine kinase-dependent activation of human NK cell functions upon stimulation through a 58-kDa surface antigen selectively expressed on discrete subsets of NK cells and T lymphocytes.

1994 • 61 citations

Human natural killer (NK) alloreactivity and its association with the major histocompatibility complex: ancestral haplotypes encode particular NK-defined haplotypes.

1993 • 21 citations