HLA-E is the ligand for the natural killer cell CD94/NKG2 receptors

Biology of Natural Killer Cells

1989 • 2,970 citations

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Human Diversity in Killer Cell Inhibitory Receptor Genes

1997 • 1,052 citations

A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells

1997 • 933 citations

Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

1998 • 892 citations

The Three-Dimensional Structure of Peptide-MHC Complexes

1995 • 817 citations

Viral Strategies of Immune Evasion

1998 • 791 citations

Functionally and Structurally Distinct NK Cell Receptor Repertoires in the Peripheral Blood of Two Human Donors

1997 • 735 citations

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by CD94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis

1998 • 706 citations

Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAP

1996 • 697 citations

A Novel Immunoglobulin Superfamily Receptor for Cellular and Viral MHC Class I Molecules

1997 • 681 citations

Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

1996 • 625 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.

1998 • 498 citations

The human major histocompatibility complex class Ib molecule HLA‐E binds signal sequence‐derived peptides with primary anchor residues at positions 2 and 9

1997 • 489 citations

Human placental HLA-G expression is restricted to differentiated cytotrophoblasts.

1995 • 479 citations

Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.

1996 • 441 citations

Activation and function of natural killer cell responses during viral infections

1997 • 430 citations

DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.

1991 • 430 citations

Cutting Edge: Human Myelomonocytic Cells Express an Inhibitory Receptor for Classical and Nonclassical MHC Class I Molecules

1998 • 430 citations

A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing

1997 • 426 citations

Nature of polymorphism in HLA-A, -B, and -C molecules.

1988 • 379 citations

The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.

1996 • 365 citations

MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide binding

1994 • 356 citations

Regulation of MHC Class I Transport by the Molecular Chaperone, Calnexin (p88, IP90)

1994 • 351 citations

A human killer inhibitory receptor specific for HLA-A1,2.

1996 • 347 citations

The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.

1996 • 337 citations

The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells

1997 • 327 citations

A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

1997 • 327 citations

Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones

1995 • 308 citations

Interaction of MHC Class I Molecules with the Transporter Associated with Antigen Processing

1994 • 300 citations

Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: Structural evidence for new stimulatory and inhibitory pathways

1997 • 298 citations

The role of natural killer cells in immune surveillance of cancer

1995 • 290 citations

Evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line.

1986 • 288 citations

Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen

1994 • 275 citations

TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide

1998 • 275 citations

The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

1997 • 271 citations

Nomenclature for Factors of the HLA System, 1995

1995 • 265 citations

Nomenclature for factors of the HLA system. 1995

1995 • 254 citations

NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor

1997 • 252 citations

Antigen Presentation by Major Histocompatibility Complex Class I-B Molecules

1994 • 248 citations

Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses

1998 • 245 citations

Generation of Allospecific Natural Killer Cells by Stimulation Across a Polymorphism of HLA-C

1993 • 241 citations

HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.

1988 • 239 citations

HLA class I-specific inhibitory receptors in human T lymphocytes: Interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8⁺ T cells

1998 • 237 citations

Natural Killer Cells: From No Receptors to Too Many

1997 • 236 citations

Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases

1998 • 236 citations

Apoptosis Signaling Pathway in T Cells Is Composed of ICE/Ced-3 Family Proteases and MAP Kinase Kinase 6b

1997 • 234 citations

Specificity, tolerance and developmental regulation of natural killer cells defined by expression of class I‐specific Ly49 receptors

1997 • 232 citations

Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.

1997 • 229 citations

Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue

1990 • 224 citations

Diversity and diversification of HLA-A,B,C alleles.

1989 • 224 citations

Killer cell inhibitory receptors: diversity, specificity, and function

1997 • 223 citations

Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA‐Cw4 molecules

1997 • 216 citations

Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C.

1996 • 213 citations

Molecular characterization of human CD94: A type II membrane glycoprotein related to the C‐type lectin superfamily

1995 • 207 citations

Structural Features Impose Tight Peptide Binding Specificity in the Nonclassical MHC Molecule HLA-E

1998 • 206 citations

Nonclassical HLA-G molecules are classical peptide presenters

1996 • 201 citations

Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.

1994 • 193 citations

CD94 and a Novel Associated Protein (94AP) Form a NK Cell Receptor Involved in the Recognition of HLA-A, HLA-B, and HLA-C Allotypes

1996 • 187 citations

Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type.

1993 • 178 citations

The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G.

1995 • 171 citations

Interleukin‐15‐induced maturation of human natural killer cells from early thymic precursors: selective expression of CD94/NKG2‐A as the only HLA class I‐specific inhibitory receptor

1997 • 162 citations

Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules.

1995 • 157 citations

Follow the Leader: NK Cell Receptors for Classical and Nonclassical MHC Class I

1998 • 156 citations

A Point Mutation in HLA-A*0201 Results in Failure to Bind the TAP Complex and to Present Virus-Derived Peptides to CTL

1996 • 139 citations

A novel functional cell surface dimer (Kp43) expressed by natural killer cells and T cell receptor-gamma/delta+ T lymphocytes. I. Inhibition of the IL-2-dependent proliferation by anti-Kp43 monoclonal antibody.

1990 • 136 citations

CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies

1996 • 133 citations

Population genetic studies of HLA-E

1997 • 131 citations

A multigene family on human chromosome 12 encodes natural killer-cell lectins

1993 • 125 citations

Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen.

1995 • 124 citations

Cloning of a mouse homolog of CD94 extends the family of C‐type lectins on murine natural killer cells

1997 • 122 citations

Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis

1997 • 107 citations

Interaction of HLA-E with Peptides and the Peptide Transporter In Vitro: Implications for its Function in Antigen Presentation

1998 • 101 citations

The activating form of CD94 receptor complex: CD94 covalently associated with the Kp39 protein that represents the product of the NKG2-C gene

1998 • 98 citations

An unstable beta 2-microglobulin: major histocompatibility complex class I heavy chain intermediate dissociates from calnexin and then is stabilized by binding peptide.

1994 • 93 citations

The MHC E locus in macaques is polymorphic and is conserved between macaques and humans

1995 • 90 citations

Natural killer cell receptors

1997 • 88 citations

The MHC-E Locus Is the Most Well Conserved of All Known Primate Class I Histocompatibility Genes

1998 • 85 citations

Structure of the HLA class I region and expression of its resident genes

1993 • 85 citations

The HLA-E gene encodes two differentially regulated transcripts and a cell surface protein.

1992 • 81 citations

Self and viral peptides can initiate lysis by autologous natural killer cells

1997 • 79 citations

Structural and Functional Characteristics of the Class Ib Molecule, Qa-1

1995 • 70 citations

Molecular characterization of a gene in the rat homologous to human CD94

1997 • 65 citations

A novel functional cell surface dimer (Kp43) expressed by natural killer cells and gamma/delta TCR+ T lymphocytes. II. Modulation of natural killer cytotoxicity by anti-Kp43 monoclonal antibody.

1991 • 61 citations

Impaired intracellular transport and cell surface expression of nonpolymorphic HLA-E: evidence for inefficient peptide binding.

1992 • 61 citations

Biochemical and serologic evidence for the existence of functionally distinct forms of the CD94 NK cell receptor.

1996 • 59 citations

Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses.

1996 • 58 citations

Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene.

1988 • 57 citations

Cloning of NKG2‐F, a new member of the NKG2 family of human natural killer cell receptor genes

1997 • 55 citations

Putting together an MHC class I molecule

1993 • 53 citations

A cDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site.

1993 • 42 citations

Isolation and characterization of NK cell or NK/T cell-specific cDNA clones.

1990 • 42 citations

Natural killer lectin-like receptors have divergent carboxyl-termini, distinct from C-type lectins

1994 • 40 citations

Polymorphism in the human class I MHC locusHLA-E in Japanese

1990 • 36 citations

Identification of Natural Killer (NK) Cells in Lesions of Human Cutaneous Graft-Versus-Host Disease: Expression of a Novel NK-Associated Surface Antigen (Kp43) in Mononuclear Infiltrates

1991 • 35 citations

A cDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site.

1993 • 35 citations

Hybrid resistance and the Ly-49 family of natural killer cell receptors.

1995 • 32 citations

The role of natural killer cells in transplantation

1995 • 29 citations

High polymorphism of Mhc‐E locus in non‐human primates: alleles with identical exon 2 and 3 are found in two different species

1997 • 26 citations

A novel functional cell surface dimer (kp43) serves as accessory molecule for the activation of a subset of human gamma delta T cells.

1993 • 26 citations

Description of a New HLA-E (E∗01031) Allele and Its Frequency in the Spanish Population

1997 • 24 citations

Reproducibility of global photographic assessments of patients with male pattern baldness in a clinical trial with finasteride.

1995 • 13 citations