Resolvins, docosatrienes, and neuroprotectins, novel omega‐3‐derived mediators, and their endogenous aspirin‐triggered epimers

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Resolvins

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A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET

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Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

2000 • 1,136 citations

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

2003 • 1,058 citations

Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

2003 • 965 citations

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

2004 • 936 citations

Mechanisms of action of docosahexaenoic acid in the nervous system

2001 • 909 citations

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

2005 • 890 citations

Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression

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Role of Prostacyclin in the Cardiovascular Response to Thromboxane A ₂

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Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.

1984 • 728 citations

Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

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Inflammation: Basic Principles and Clinical Correlates

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C-Reactive Protein and the Risk of Incident Colorectal Cancer

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Resolution of Inflammation: A New Paradigm for the Pathogenesis of Periodontal Diseases

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Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

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Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.

1994 • 431 citations

Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis.

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Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators

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Workshop on the Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids

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The diversity of the lipoxygenase family

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Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction.

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Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils.

1984 • 270 citations

Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis

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The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase

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Lipoxygenase genes and their targeted disruption

2002 • 186 citations

A single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation

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Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense

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The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3

1996 • 176 citations

Novel Lipid Mediator Regulators of Endothelial Cell Proliferation and Migration: Aspirin-Triggered-15R-Lipoxin A₄and Lipoxin A₄

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A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET

2009 • 155 citations

Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways

2001 • 149 citations

Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog

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Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils.

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From studies of biochemical mechanism to novel biological mediators: Prostaglandin endoperoxides, thromboxanes, and leukotriences

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Proceedings of the AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids

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P-selectin mediates the interaction of circulating leukocytes with platelets and microvascular endothelium in response to oxidized lipoprotein in vivo.

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Lipoxin A4 and Aspirin-Triggered 15-epi-Lipoxin A4 Inhibit Human Neutrophil Migration: Comparisons Between Synthetic 15 Epimers in Chemotaxis and Transmigration with Microvessel Endothelial Cells and Epithelial Cells

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Arachidonate 5-lipoxygenase

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Inflammation Protocols

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Diets could prevent many diseases

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Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis

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Association of a Lipoxygenase Locus,Lpx‐B1, with Variation in Lipoxygenase Activity in Durum Wheat Seeds

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Adventures and excursions in bioassay: the stepping stones to prostacyclin

1983 • 88 citations

Formation of Novel D-Ring and E-Ring Isoprostane-like Compounds (D₄/E₄-Neuroprostanes) in Vivo from Docosahexaenoic Acid

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Les Prix Nobel : Nobel Prizes, presentations, biographies and lectures

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Lipoxin Biosynthesis by Trout Macrophages Involves the Formation of Epoxide Intermediates

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Differential Signaling of Formyl Peptide Receptor-Like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH₂or Lipoxin A4 in Human Neutrophils

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Lipoxygenation of Docosahexaenoic Acid by the Rat Pineal Body

1994 • 48 citations

Adventures and Excursions in Bioassay: The Stepping Stones to Prostacylin

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Arachidonate 8(S)-lipoxygenase

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