International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

The PPARα–leukotriene B4 pathway to inflammation control

1996 • 1,328 citations

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

2001 • 1,072 citations

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

1981 • 1,030 citations

Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

1979 • 992 citations

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1997 • 990 citations

Leukotrienes are potent constrictors of human bronchi

1980 • 984 citations

Characterization of the human cysteinyl leukotriene CysLT1 receptor

1999 • 960 citations

Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.

1984 • 728 citations

Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

1979 • 652 citations

Characterization of the Human Cysteinyl Leukotriene 2 Receptor

2000 • 649 citations

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

1976 • 638 citations

The release of histamine and formation of a slow‐reacting substance (SRS‐A) during anaphylactic shock

1960 • 638 citations

Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro.

1980 • 634 citations

Local Effects of Synthetic Leukotrienes (LTC4, LTD4, and LTB4) in Human Skin

1983 • 585 citations

Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.

1979 • 556 citations

A Second Leukotriene B4 Receptor, Blt2

2000 • 539 citations

Leukotriene E4 and granulocytic infiltration into asthmatic airways

1993 • 537 citations

The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs).

1980 • 518 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids.

1979 • 465 citations

Selective Inhibitor of Slow Reacting Substance of Anaphylaxis

1973 • 443 citations

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

2002 • 441 citations

Slow reacting substances of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sources

1980 • 433 citations

Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.

1994 • 431 citations

Aspirin-triggered 15-Epi-Lipoxin A4 (LXA4) and LXA4 Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors

1997 • 427 citations

Structure of slow-reacting substance of anaphylaxis from guinea-pig lung

1980 • 426 citations

Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro.

1982 • 419 citations

THE LIBERATION OF A SLOW‐REACTING SMOOTH MUSCLE‐STIMULATING SUBSTANCE IN ANAPHYLAXIS

1940 • 416 citations

Bronchoconstrictor Effects of Leukotriene C in Humans

1982 • 404 citations

Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets

1975 • 393 citations

Liberation of histamine and formation of lysocithin‐like substances by cobra venom

1938 • 372 citations

Stereospecific total synthesis of a "slow reacting substance" of anaphylaxis, leukotriene C-1

1980 • 369 citations

The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R

2002 • 356 citations

Identification, Molecular Cloning, Expression, and Characterization of a Cysteinyl Leukotriene Receptor

1999 • 349 citations

Design of Lipoxin A4 Stable Analogs That Block Transmigration and Adhesion of Human Neutrophils

1995 • 326 citations

Heptahelical Receptor Signaling: Beyond the G Protein Paradigm

1999 • 323 citations

Identification and biological activity of novel ω‐oxidized metabolites of leukotriene B₄ from human leukocytes

1981 • 313 citations

Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.

1984 • 309 citations

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

1990 • 299 citations

Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction.

1996 • 288 citations

Effects of Leukotriene D on the Airways in Asthma

1983 • 288 citations

Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro

1981 • 285 citations

Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes.

1986 • 283 citations

Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4.

1988 • 278 citations

Effects of LTD₄ on Human Airway Smooth Muscle Cell Proliferation, Matrix Expression, and Contraction In Vitro: Differential Sensitivity to Cysteinyl Leukotriene Receptor Antagonists

1998 • 275 citations

Lipoxin biosynthesis and its impact in inflammatory and vascular events

1994 • 275 citations

Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D₄ receptor antagonist

1989 • 266 citations

Lipoxin A4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin A4 Receptor

1997 • 266 citations

Specific binding of leukotriene B4 to receptors on human polymorphonuclear leukocytes.

1982 • 263 citations

Activation of Lipoxin a4 Receptors by Aspirin-Triggered Lipoxins and Select Peptides Evokes Ligand-Specific Responses in Inflammation

2000 • 262 citations

Lipoxin A₄: A New Class of Ligand for the Ah Receptor

1999 • 257 citations

Airway Responsiveness to Leukotrienes C4 and D4 and to Methacholine in Patients with Asthma and Normal Controls

1986 • 256 citations

Expression of the Cysteinyl Leukotriene 1 Receptor in Normal Human Lung and Peripheral Blood Leukocytes

2001 • 254 citations

Pharmacology of montelukast sodium (Singulair™), a potent and selective leukotriene D₄receptor antagonist

1995 • 252 citations

Pulmonary responses to bronchoconstrictor agonists in the mouse

1988 • 251 citations

Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): A jungle of cell-cell interactions or a therapeutic opportunity?

1997 • 243 citations

Effects of Prostaglandins on Human Bronchial Muscle

1968 • 240 citations

Leukotriene B4 is a complete secretagogue in human neutrophils: A kinetic analysis

1982 • 237 citations

Immunologic and Neuropharmacologic Stimulation of Mucous Glycoprotein Release from Human Airways In Vitro

1980 • 235 citations

Leukotriene B4: Metabolism and Signal Transduction

2001 • 232 citations

Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues.

1998 • 231 citations

REACTIONS OF ISOLATED HUMAN ASTHMATIC LUNG AND BRONCHIAL TISSUE TO A SPECIFIC ANTIGEN HISTAMINE RELEASE AND MUSCULAR CONTRACTION

1951 • 222 citations

Lipoxin A4 and Lipoxin B4 Inhibit Chemotactic Responses of Human Neutrophils Stimulated by Leukotriene B4 and N-Formyl-<scp>l</scp>-Methionyl-<scp>l</scp>-Leucyl-<scp>l</scp>-Phenylalanine

1989 • 220 citations

Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion

1999 • 219 citations

Leukotriene D ₄ : a Potent Coronary Artery Vasoconstrictor Associated with Impaired Ventricular Contraction

1982 • 218 citations

Identification of a Human Enterocyte Lipoxin A4 Receptor That Is Regulated by Interleukin (IL)-13 and Interferon γ and Inhibits Tumor Necrosis Factor α–induced IL-8 Release

1998 • 209 citations

Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitmentin vivo

1999 • 209 citations

A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family.

1992 • 207 citations

The Synthetic Peptide Trp-Lys-Tyr-Met-Val-Met-NH2 Specifically Activates Neutrophils through FPRL1/Lipoxin A4 Receptors and Is an Agonist for the Orphan Monocyte-expressed Chemoattractant Receptor FPRL2

2001 • 202 citations

Hydroxyeicosanoids Bind to and Activate the Low Affinity Leukotriene B4 Receptor, BLT2

2001 • 200 citations

Leukotriene C4 affects pulmonary and cardiovascular dynamics in monkey

1982 • 199 citations

Lipoxin (LX)A4 and Aspirin-triggered 15-epi-LXA4 Inhibit Tumor Necrosis Factor 1α–initiated Neutrophil Responses and Trafficking: Regulators of a Cytokine–Chemokine Axis

1999 • 198 citations

The Molecular Characterization and Tissue Distribution of the Human Cysteinyl Leukotriene CysLT2 Receptor

2000 • 198 citations

Bltr Mediates Leukotriene B4–Induced Chemotaxis and Adhesion and Plays a Dominant Role in Eosinophil Accumulation in a Murine Model of Peritonitis

2000 • 198 citations

Molecular Cloning and Characterization of a Second Human Cysteinyl Leukotriene Receptor: Discovery of a Subtype Selective Agonist

2000 • 196 citations

Aspirin-Triggered Lipoxins (15-epi-LX) Are Generated by the Human Lung Adenocarcinoma Cell Line (A549)–Neutrophil Interactions and Are Potent Inhibitors of Cell Proliferation

1996 • 189 citations

Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells.

1977 • 183 citations

A novel mechanism for the Ca(2+)-sensitizing effect of protein kinase C on vascular smooth muscle: inhibition of myosin light chain phosphatase.

1994 • 182 citations

Oxidoreductases in Lipoxin A4 Metabolic Inactivation

2000 • 179 citations

Leukotrienes C4, D4 and E4: effects on human and guinea-pig cardiac preparations in vitro.

1982 • 178 citations

Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells

2001 • 178 citations

Targeted Disruption of the Leukotriene B4Receptor in Mice Reveals Its Role in Inflammation and Platelet-Activating Factor–Induced Anaphylaxis

2000 • 177 citations

Effects of leukotrienes C4 and D4 on glycoprotein and lysozyme secretion by human bronchial mucosa

1983 • 172 citations

Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19

1992 • 171 citations

Effect of leukotriene D₄ on nasal mucosal blood flow, nasal airway resistance and nasal secretion in humans

1986 • 171 citations

The mechanism of vascular leakage induced by leukotriene E4. Endothelial contraction.

1987 • 169 citations

Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor

1992 • 168 citations

The physicochemical characteristics and purification of slow-reacting substance of anaphylaxis.

1973 • 167 citations

Selectivity of Recombinant Human Leukotriene D4, Leukotriene B4, and Lipoxin A4 Receptors with Aspirin-Triggered 15-epi-LXA4 and Regulation of Vascular and Inflammatory Responses

2001 • 167 citations

The effect of inhaled leukotriene D4 in humans.

1985 • 163 citations

Growth Hormone and Premature Ageing

1973 • 163 citations

A second cysteinyl leukotriene receptor in human lung.

1992 • 163 citations

Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs.

1998 • 162 citations

IL-13 and IL-4 Up-Regulate Cysteinyl Leukotriene 1 Receptor Expression in Human Monocytes and Macrophages

2001 • 160 citations

Comparison of leukotriene B4 and D4 effects on human eosinophil and neutrophil motility in vitro

1994 • 159 citations

Molecular and Biological Characterization of the Murine Leukotriene B4 Receptor Expressed on Eosinophils

1998 • 159 citations

The Preclinical Pharmacology of ICI 204,219: A Peptide Leukotriene Antagonist

1990 • 155 citations

The Effects of Lipoxin A₄on Airway Responses in Asthmatic Subjects

1992 • 154 citations

Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors

1993 • 154 citations

Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: evidence for competition at a common receptor.

1989 • 153 citations

Prostanoid and leukotriene receptors: a progress report from the IUPHAR working parties on classification and nomenclature.

1995 • 150 citations

Eosinophil peroxidase-mediated inactivation of leukotrienes B4, C4, and D4.

1982 • 149 citations

Receptor class desensitization of leukocyte chemoattractant receptors.

1991 • 146 citations

Pharmacologic profile of SK&F 104353: a novel, potent and selective peptidoleukotriene receptor antagonist in guinea pig and human airways.

1987 • 146 citations

The Physicochemical Characteristics and Purification of Slow-Reacting Substance of Anaphylaxis

1973 • 146 citations

Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils.

1992 • 142 citations

Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody.

1996 • 141 citations

Molecular evolution of receptors for eicosanoids

1995 • 141 citations

Role of Leukotriene D₄in Allergen-induced Increases in Airway Smooth Muscle in the Rat

1993 • 137 citations

Leukotrienes C4, D4 and E4 cause widespread and extensive plasma extravasation in the guinea pig

1985 • 134 citations

Pharmacological study of the contractile activity of leukotriene C₄ and D₄ on isolated human airway smooth muscle

1982 • 134 citations

Molecular Cloning of a Novel P2 Purinoceptor from Human Erythroleukemia Cells

1996 • 134 citations

Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects.

1987 • 133 citations

Pharmacological evidence that human intralobar airways do not contain different receptors that mediate contractions to leukotriene C4 and leukotriene D4.

1986 • 132 citations

Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450.

1985 • 130 citations

Cyclooxygenase-2-Derived Prostaglandin E2 and Lipoxin A4 Accelerate Resolution of Allergic Edema inAngiostrongylus costaricensis-Infected Rats: Relationship with Concurrent Eosinophilia

2000 • 129 citations

Electrophysiological properties and chemosensitivity of guinea pig nodose ganglion neurons in vitro

1993 • 126 citations

Lipoxin A4 Receptor Activation Is Distinct from That of the Formyl Peptide Receptor in Myeloid Cells: Inhibition of CD11/18 Expression by Lipoxin A4-Lipoxin A4 Receptor Interaction

1995 • 123 citations

Molecular cloning and characterization of another leukotriene B4 receptor

2000 • 122 citations

Pharmacological evidence for a distinct leukotriene C4 receptor in guinea-pig trachea.

1984 • 122 citations

Contraction of isolated airway smooth muscle by synthetic leukotrienes C4 and D4

1981 • 120 citations

Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis

1995 • 120 citations

Lipoxin A4 Antagonizes the Mitogenic Effects of Leukotriene D4 in Human Renal Mesangial Cells

2000 • 119 citations

Lipoxin, leukotriene, and PDGF receptors cross‐talk to regulate mesangial cell proliferation

2002 • 117 citations

Leukotriene B4 Stimulates Rac-ERK Cascade to Generate Reactive Oxygen Species That Mediates Chemotaxis

2002 • 116 citations

Differential Leukotriene Constrictor Responses in Human Atherosclerotic Coronary Arteries

1998 • 116 citations

The effect of synthetic leukotrienes on tracheal microvascular permeability

1983 • 112 citations

Lipoxin A₄stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: Role of P-selectin

1997 • 112 citations

The effect of leucotriene C4 and D4 on cutaneous blood flow in humans

1982 • 111 citations

On the structure of slow reacting substance of anaphylaxis: Evidence of biosynthesis from arachidonic acid

1977 • 111 citations

In vivo pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist.

1987 • 108 citations

Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase.

1993 • 108 citations

The formation of lysocithin and of a muscle-stimulating substance by snake venoms

1938 • 108 citations

Immunologically induced neuromodulation of guinea pig nodose ganglion neurons

1993 • 107 citations

The synthesis of a leukotriene with SRS-like activity

1980 • 106 citations

Cutting Edge: Nociceptin Stimulates Neutrophil Chemotaxis and Recruitment: Inhibition by Aspirin-Triggered-15-Epi-Lipoxin A4

2001 • 106 citations

Peptido-Leukotrienes Are Potent Agonists of von Willebrand Factor Secretion and P-Selectin Surface Expression in Human Umbilical Vein Endothelial Cells

1995 • 105 citations

Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a ‘stop’ signaling switch for aspirin‐triggered lipoxin A₄

1999 • 104 citations

Peptidoleukotrienes: Distinct receptors for leukotriene C4 and D4 in the Guinea-pig lung

1983 • 104 citations

Heterogeneity of leukotriene receptions in guinea-pig trachea

1983 • 104 citations

Coronary constriction by leukotriene C4, D4, and E4 in the intact pig heart

1983 • 103 citations

The myeloperoxidase-dependent metabolism of leukotrienes C4, D4, and E4 to 6-trans-leukotriene B4 diastereoisomers and the subclass-specific S-diastereoisomeric sulfoxides.

1983 • 98 citations

Cell-Specific Transcriptional Regulation of Human Leukotriene B4 Receptor Gene

2000 • 98 citations

Ca2+-Dependent Production and Release of IL-8 in Human Neutrophils

1998 • 97 citations

Leukotriene C4 binding to rat lung membranes.

1983 • 97 citations

The signal transduction system of the leukotriene D4 receptor

1989 • 96 citations

Leukotriene D4 activates MAPK through a Ras-independent but PKCϵ-dependent pathway in intestinal epithelial cells

2002 • 94 citations

Effects of lipoxin A₄on chemotaxis and degranulation of human eosinophils stimulated by platelet-activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylalanine

1994 • 94 citations

Evidence for multiple leukotriene D4 receptors in smooth muscle

1982 • 91 citations

Lipoxin B₄regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B₄analogs with increased biologic activity

1998 • 89 citations

BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes

1994 • 87 citations

Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats

1999 • 86 citations

In Vivo Pharmacologic Profile of ONO-1078: A Potent, Selective and Orally Active Peptide Leukotriene (LT) Antagonist.

1992 • 86 citations

Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism.

1997 • 83 citations

cDNA Cloning, Expression, and Mutagenesis Study of Leukotriene B4 12-Hydroxydehydrogenase

1996 • 82 citations

Activation of human monocytes and the acute monocytic leukemia cell line (THP-1) by lipoxins involves unique signaling pathways for lipoxin A4 versus lipoxin B4: evidence for differential Ca2+ mobilization.

1996 • 80 citations

Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils

2001 • 79 citations

Induction of functional lipoxin A4 receptors in HL-60 cells

1993 • 79 citations

Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219

1993 • 78 citations

Leukotriene D4 and E4 induce transmembrane signaling in human epithelial cells. Single cell analysis reveals diverse pathways at the G-protein level for the influx and the intracellular mobilization of Ca2+.

1990 • 78 citations

Human umbilical vein endothelial cells generate leukotriene C₄ via microsomal glutathione S‐transferase type 2 and express the CysLT₁ receptor

2001 • 78 citations

A Novel Hepatointestinal Leukotriene B4 Receptor

2000 • 78 citations

The Murine Cysteinyl Leukotriene 2 (CysLT2) Receptor

2001 • 77 citations

IL-5 Up-Regulates Cysteinyl Leukotriene 1 Receptor Expression in HL-60 Cells Differentiated into Eosinophils

2000 • 75 citations

Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes.

1985 • 73 citations

Cloning and Characterization of cDNA Encoding a Novel Human Leukotriene B4 Receptor

2000 • 71 citations

Characterization of the two major species of slow reacting substance from rat basophilic leukemia cells as glutathionyl thioethers of eicosatetraenoic acids oxygenated at the 5 position. Evidence that peroxy groups are present and important for spasmogenic activity

1979 • 71 citations

Peptide Leukotriene Involvement in Pulmonary Eosinophil Migration upon Antigen Challenge in the Actively Sensitized Guinea Pig

1991 • 70 citations

Leukotriene D4 Activates Mitogen-activated Protein Kinase through a Protein Kinase Cα-Raf-1-dependent Pathway in Human Monocytic Leukemia THP-1 Cells

1998 • 69 citations

Molecular heterogeneity of leukotriene receptors: correlation of smooth muscle contraction and radioligand binding in guinea-pig lung.

1985 • 69 citations

Pharmacological and biochemical evidence for metabolism of peptide leukotrienes by guinea-pig airway smooth muscle in vitro.

1984 • 69 citations

Polyisoprenyl phosphates in intracellular signalling

1997 • 68 citations

Transduction by leukotriene B4 receptors of increases in cytosolic calcium in human polymorphonuclear leukocytes.

1985 • 67 citations

Specific receptors for leukotriene C4 on a smooth muscle cell line.

1983 • 66 citations

Coronary vasoconstriction induced by leukotrienes in the anaesthetized dog

1982 • 66 citations

Functional Characterization of Cysteinyl Leukotriene CysLT2 Receptor on Human Coronary Artery Smooth Muscle Cells

2001 • 65 citations

Lipoxin A₄ and lipoxin B₄ stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: Dissociation between lipid remodeling and adhesion

1990 • 64 citations

Aspirin‐triggered lipoxin A ₄ and lipoxin A ₄ up‐regulate transcriptional corepressor NAB1 in human neutrophils

2001 • 64 citations

Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing

2001 • 63 citations

Effects of the leukotrienes on the vasculature and blood pressure of different species.

1984 • 63 citations

Tissue distribution and functional correlation of [3H]leukotriene C4 and [3H]leukotriene D4 binding sites in guinea-pig uterus and lung preparations.

1985 • 63 citations

Role of peptidoleukotrienes in capsaicin‐sensitive sensory fibre‐mediated responses in guinea‐pig airways.

1991 • 62 citations

Linkage and Association of Atopic Asthma to Markers on Chromosome 13 in the Japanese Population

1999 • 61 citations

Contraction of guinea pig uterus by synthetic leukotrienes

1982 • 61 citations

Characterization of Mouse Cysteinyl Leukotriene Receptors mCysLT1 and mCysLT2

2002 • 61 citations

Leukotriene receptors on human pulmonary vascular endothelium

1995 • 61 citations

Formation of sulphidopeptide‐leukotrienes by cell‐cell interaction causes coronary vasoconstriction in isolated, cell‐perfused heart of rabbit

1993 • 60 citations

Characterization of Binding of Leukotriene C4 by Human Multidrug Resistance Protein 1

2001 • 59 citations

Characterization of the airway response to inhaled leukotriene D4 in normal subjects.

1986 • 59 citations

Co-expression of two LTB4 receptors in human mononuclear cells

2001 • 59 citations

The leukotriene B₄receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells

1998 • 58 citations

Mechanisms of Airway Goblet Cell Mucin Release: Studies with Cultured Tracheal Surface Epithelial Cells

1989 • 58 citations

Is the guinea pig trachea a good in vitro model of human large and central airways? Comparison on leukotriene-, methacholine-, histamine- and antigen-induced contractions.

1987 • 58 citations

Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung

1993 • 57 citations

Leukotriene C4 uses a probenecid-sensitive export carrier that does not recognize leukotriene B4.

1992 • 57 citations

Regional and time-dependent effects of inflammatory mediators on airway microvascular permeability in the guinea pig

1989 • 57 citations

Threonine 308 within a Putative Casein Kinase 2 Site of the Cytoplasmic Tail of Leukotriene B4 Receptor (BLT1) Is Crucial for Ligand-induced, G-protein-coupled Receptor-specific Kinase 6-mediated Desensitization

2002 • 56 citations

Inhalation Challenge with Sulfidopeptide Leukotrienes in Human Subjects

1986 • 55 citations

Leukotrienes and the Pulmonary Microcirculation

1987 • 55 citations

Cardiac anaphylaxis: SRS-A potentiates and extends the effects of released histamine

1980 • 54 citations

Signalling through the leukotriene B4 receptor involves both αi and α16, but not αq or α11 G-protein subunits

1998 • 54 citations

Formation and proliferative effects of lipoxins in human bone marrow

1991 • 53 citations

Differential activity of leukotrienes upon human pulmonary vein and artery

1984 • 53 citations

Analysis of responses to leukotriene D4 in the pulmonary vascular bed.

1984 • 51 citations

Leukotriene-induced hydrolysis of inositol lipids in guinea pig lung: mechanism of signal transduction for leukotriene-D4 receptors.

1987 • 51 citations

Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl–leukotrienes

2000 • 50 citations

Lipoxin Biosynthesis by Trout Macrophages Involves the Formation of Epoxide Intermediates

1994 • 50 citations

The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543.

1998 • 48 citations

An examination of the influence of the epithelium on contractile responses to peptidoleukotrienes and blockade by ICI 204,219 in isolated guinea pig trachea and human intralobar airways.

1990 • 48 citations

Leukotriene D4 relaxes canine renal and superior mesenteric arteries.

1985 • 48 citations

Cloning and Characterization of Rat Leukotriene B4 Receptor

1999 • 48 citations

Lipoxin A 4 inhibits phosphoinositide hydrolysis in human neutrophils

1990 • 47 citations

Mechanisms of leukotriene E4 partial agonist activity at leukotriene D4 receptors in differentiated U-937 cells

1989 • 47 citations

Regulation of ligand binding to leukotriene D4 receptors: effects of cations and guanine nucleotides

1984 • 46 citations

Inhibition of antigen-induced histamine release and thromboxane synthase by FPL 55712, a specific SRA-A antagonist?

1981 • 46 citations

Differential regulation of cytokine and cytokine receptor genes by PAF, LTB4 and PGE2.

1993 • 46 citations

Cardiovascular effects of leukotrienes in neonatal piglets. Role in hypoxic pulmonary vasoconstriction?

1984 • 45 citations

Leukotriene C4 binding sites in the rat central nervous system

1986 • 45 citations

Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils

1992 • 45 citations

The Effect of Inhaled Budesonide on the Maximal Degree of Airway Narrowing to Leukotriene D₄and Methacholine in Normal SubjectsIn Vivo

1989 • 45 citations

Pharmacological evidence for a novel cysteinyl‐leukotriene receptor subtype in human pulmonary artery smooth muscle

2002 • 44 citations

Investigation of leukotriene involvement in the vasopermeability response associated with guinea pig tracheal anaphylaxis: Comparison with cutaneous anaphylaxis

1983 • 44 citations

Identification of specific binding sites for leukotriene C4 in membranes from human lung

1985 • 44 citations

Involvement of a Signal Transduction Mechanism in ATP-induced Mucin Release from Cultured Airway Goblet Cells

1993 • 43 citations

Evidence for two leukotriene receptor types in the guinea-pig isolated ileum

1990 • 43 citations

Contractile activities of leukotrienes C4 and D4 on vascular strips from rabbits

1981 • 43 citations

CALCIUM IONOPHORE A23187 INDUCES RELEASE OF CHEMOKINETIC AND AGGREGATING FACTORS FROM POLYMORPHO‐NUCLEAR LEUCOCYTES

1980 • 42 citations

Leukotriene D4 reduces coronary blood flow in the anesthetized dog

1983 • 42 citations

Cardiovascular and Metabolic Effects of Peptide Leukotrienes in Mana

1988 • 42 citations

Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction

1994 • 42 citations

Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT1) receptors11Abbreviations: LT, leukotriene; hCysLT1R, human cysteinyl-leukotriene receptor (subtype 1); mCysLT1R, mouse cysteinyl-leukotriene receptor (subtype 1); CysLT2R, cysteinyl-leukotriene receptor (subtype 2); HEK, human embryonic kidney; ORF, open reading frame; RT-PCR, reverse transcription-polymerase chain reaction; and RACE, rapid amplification of cDNA ends.

2001 • 42 citations

Angiotensin II-induced contractions in human internal mammary artery: effects of cyclooxygenase and lipoxygenase inhibition

2000 • 40 citations

The actions of leukotrienes C4 and D4 in the porcine renal vascular bed

1985 • 39 citations

Peptide leukotrienes: current status of research

1991 • 39 citations

Leukotriene D₄-Induced Activation of Smooth-Muscle Cells From Human Bronchi Is Partly Ca^{2 +}-Independent

2001 • 39 citations

Leukotrienes increase glucose and lactate output and decrease flow in perfused rat liver

1988 • 39 citations

Leukotriene Binding, Signaling, and Analysis of HIV Coreceptor Function in Mouse and Human Leukotriene B4Receptor-transfected Cells

1999 • 38 citations

Leukotriene D4 Triggers an Association between Gβγ Subunits and Phospholipase C-γ1 in Intestinal Epithelial Cells

2000 • 38 citations

Systemic hemodynamic effects of leukotrienes C4 and D4 in the rat

1983 • 38 citations

Cysteinyl leukotriene receptors in the human lung: what's new?

1996 • 37 citations

Cysteinyl leukotriene receptors in the human lung: what's new?

1996 • 37 citations

Leukotriene D₄(LTD₄) Induces Mucus Secretion from Goblet Cells in the Guinea Pig Respiratory Epithelium

1990 • 37 citations

Preferential vasoconstriction to cysteinyl leukotrienes in the human saphenous vein compared with the internal mammary artery. Implications for graft performance.

1994 • 37 citations

Leukotriene C4- and D4-induced diffuse peripheral constriction of swine coronary artery accompanied by ST elevation on the electrocardiogram: angiographic analysis.

1987 • 36 citations

Effects of Synthetic Leukotrienes on Local Blood Flow and Vascular Permeability in Porcine Skin

1985 • 36 citations

Characterization of the guinea pig lung membrane leukotriene D4 receptor solubilized in an active form. Association and dissociation with an islet-activating protein-sensitive guanine nucleotide-binding protein.

1990 • 36 citations

Leukotriene D4 Receptor Antagonism Reduces Airway Hyperresponsiveness in Monkeys

1994 • 36 citations

Cardiovascular effects of leukotriene D4 in SHR and WKY rats

1981 • 36 citations

Influence of atherosclerosis on the vascular reactivity of isolated human epicardial coronary arteries to leukotriene C4.

1993 • 36 citations

Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes

2000 • 36 citations

Stimulation by leukotriene D4 of increases in the cytosolic concentration of calcium in dimethylsulfoxide-differentiated HL-60 cells.

1987 • 36 citations

Pharmacological differences among CysLT1 receptor antagonists with respect to LTC4 and LTD4 in human lung parenchyma

2002 • 36 citations

Effects of intra-coronary administration of leukotriene D4 in the anaesthetized dog

1983 • 35 citations

Platelet activating factor and tracheobronchial respiratory glycoconjugate release in feline and human explants: Involvement of the lipoxygenase pathway

1990 • 35 citations

Effects of leukotrienes C4 and D4 on human isolated saphenous veins.

1992 • 35 citations

Release of Substance P from Guinea Pig Trachea Leukotriene D₄

1990 • 33 citations

Specific binding of leukotriene C4 to ileal segments and subcellular fractions of ileal smooth muscle cells.

1984 • 33 citations

Characterization of lipoxins by combined gas chromatography and electron-capture negative ion chemical ionization mass spectrometry: Formation of lipoxin A4 by stimulated human whole blood

1991 • 33 citations

The binding of [3H]leukotriene C4 to guinea-pig lung membranes. The lack of correlation of LTC4 functional activity with binding affinity

1987 • 33 citations

Lipoxins Inhibit Microvascular Inflammatory Actions of Leukotriene B4

1991 • 33 citations

Influences of gender and maturation of responses of guinea-pig airway tissues to LTD4

1985 • 33 citations

Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig

1995 • 33 citations

Peptidoleukotrienes induce an endothelium-dependent relaxation of guiena pig main pulmonary artery and thoratic aorta

1987 • 33 citations

Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents.

1990 • 32 citations

Effects of leukotriene C4 on the cerebral microvasculature

1986 • 32 citations

Slow Reacting Substance

1965 • 32 citations

Kinetic and pharmacologic analysis of [3H]leukotriene E4 binding to receptors on guinea pig lung membranes: evidence for selective binding to a subset of leukotriene D4 receptors.

1989 • 31 citations

Effects of peptide leukotrienes on cardiac dynamics in rat, cat, and guinea pig hearts

1985 • 31 citations

Leukotriene- and Histamine-Induced Increases in Vascular Permeability and Interstitial Transport in the Skin

1985 • 31 citations

A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma.

2000 • 31 citations

Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins

2002 • 31 citations

Leukotriene C4 Is a Tight-binding Inhibitor of Microsomal Glutathione Transferase-1

1999 • 30 citations

Leukotriene B4 receptors on guinea pig alveolar eosinophils.

1991 • 30 citations

Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H]leukotriene D4 and [3H]leukotriene C4 binding: Demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptors

1984 • 29 citations

LTD4 increases cytosolic free calcium and inositol phosphates in human neutrophils: inhibition by the novel LTD4 receptor antagonist, SR2640, and possible relation to modulation of chemotaxis

1990 • 29 citations

Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho

1996 • 29 citations

Leukotriene D4 relaxes canine renal and superior mesenteric arteries.

1985 • 29 citations

Solubilization and characterization of leukotriene B4 receptor-GTP binding protein complex from porcine spleen

1990 • 28 citations

Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung.

1993 • 28 citations

Involvement of capsaicin-sensitive afferent neurones in a vagal-dependent interaction between leukotriene D4 and histamine on bronchomotor tone

1984 • 28 citations

The regulation of leukotriene D4-induced calcium influx in human epithelial cells involves protein tyrosine phosphorylation

1995 • 28 citations

Biochemical and Pharmacological Characterization of the Binding of the Selective Peptide‐Leukotriene Antagonist, 3H‐ICI 198,615, to Leukotriene D₄ Receptors in Guinea‐Pig Lung Membranes

1988 • 27 citations

Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils

1990 • 27 citations

Transport and in vivo elimination of cysteinyl leukotrienes

1992 • 26 citations

Peptidoleukotriene binding in guinea pig uterine membrane preparations

1984 • 26 citations

The binding of leukotriene C4 and leukotriene D4 to membranes of a smooth muscles cell line (BC3H1) and evidence that leukotriene induced contraction in these cells is mediated by thromboxane, protein and RNA syntheses

1985 • 26 citations

Cardiac actions of leukotrienes B4, C4, D4, and E4 in guinea pig and rat in vitro.

1983 • 26 citations

Effect of a peptide leukotriene antagonist, ONO-1078 on antigen-induced airway microvascular leakage in actively sensitized guinea pigs

1992 • 26 citations

Subcellular distribution of leukotriene C4 binding units in cultured bovine aortic endothelial cells.

1986 • 25 citations

Heterogeneity of binding sites for ICI 198,615 in human lung parenchyma

1992 • 25 citations

Evidence for a similar receptor site for binding of [3H]leukotriene E4 and [3H]leukotriene D4 to the guinea-pig crude lung membrane

1984 • 25 citations

Vasomotor Effects of Leukotrienes C₄ and D₄ on Cavian Pulmonary Artery and Aorta Characterization and Mechanisms^a,^b

1988 • 25 citations

Pharmacological study of the effects of leukotrienes C4, D4, E4 &amp; F4 on guinea pig trachelis: Interaction with FPL-55712

1983 • 25 citations

Effects of <scp>l</scp>‐serine borate on antagonism of leukotriene C₄‐induced contractions of guinea‐pig trachea

1987 • 24 citations

Leukotriene D4 affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events

2001 • 24 citations

Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry.

1998 • 24 citations

Localization of the Site of the Bronchoconstrictor Effects of Leukotriene C₄Compared with That of Histamine in Asthmatic Subjects

1989 • 24 citations

Effects of eicosanoids, neuromediators and bioactive peptides on murine airways

2000 • 23 citations

Leukotriene D4: cardiovascular and sympathetic effects in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats.

1982 • 23 citations

Actions of Lipoxins A4 and B4 on Signal Transduction Events in Friend Erythroleukemia Cells

1992 • 22 citations

2-Nor-leukotriene analogs: Antagonists of the airway and vascular smooth muscle effects of leukotriene C4, D4 and E4

1983 • 22 citations

Mutations of Serine 236−237 and Tyrosine 302 Residues in the Human Lipoxin A₄ Receptor Intracellular Domains Result in Sustained Signaling

2000 • 22 citations

Lung tissue receptors for sulfidopeptide leukotrienes

1984 • 22 citations

Binding of leukotriene C4 by glutathione transferase: a reassessment of biochemical and functional criteria for leukotriene receptors.

1987 • 22 citations

Divergent influences of leukotrienes C4, D4, and E4 on mesenteric and renal blood flow

1984 • 22 citations

Effects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels.

1996 • 22 citations

Signal transduction processes for the LTD4 receptor.

1990 • 21 citations

The Differential Effects of Leukotriene C4 and D4 on the Pulmonary and Systemic Circulations in Newborn Lambs

1987 • 21 citations

Characterisation of the peptido-leukotriene receptor PL2 on the ferret spleen strip

1993 • 21 citations

Mechanism of action of cysteinyl leukotrienes on glucose and lactate balance and on flow in perfused rat liver

1989 • 21 citations

The inhibition of [3H]leukotriene D4 binding to guinea-pig lung membranes. The correlation of binding affinity with activity on the guinea-pig ileum

1990 • 21 citations

Specificity and cellular distribution of human polymorphonuclear leucocyte receptors for leukotriene C4.

1987 • 21 citations

EFFECTS OF VARIOUS PHARMACOLOGICAL AGENTS ON ISOLATED HUMAN BRONCHIAL AND PULMONARY ARTERIAL AND VENOUS MUSCLE PREPARATIONS CONTRACTED BY LEUKOTRIENE D₄

1987 • 21 citations

Characterization of [3H]leukotriene D4 binding sites in guinea-pig ventricular myocardium.

1985 • 20 citations

Leukotriene D4 receptor-mediated phosphoinositol hydrolysis and calcium mobilization in rat basophilic leukemic cells.

1988 • 20 citations

Comparative study of the pulmonary effects of intravenous leukotrienes and other bronchoconstrictors in anaesthetized guinea pig

1985 • 20 citations

Mechanism of the negative inotropic action of leukotrienes C4 and D4 on isolated rat heart

1985 • 20 citations

Leukotriene receptors and their selective antagonists.

1994 • 19 citations

Characterization of the leukotriene D4 receptor in hyperreactive rat lung

1991 • 19 citations

Characterization of guinea pig myocardial leukotriene C4 binding sites. Regulation by cations and sulfhydryl-directed reagents.

1985 • 19 citations

Identification of leukotriene D4 specific binding sites in the membrane preparation isolated from guinea pig lung

1984 • 19 citations

Leukotrienes C4 and D4 are potent endothelium-dependent relaxing agents in canine splanchnic venous capacitance vessels.

1993 • 18 citations

M1/MUC5AC mucin released by human airways in vitro

1999 • 18 citations

Pharmacological characterization of the cysteinyl‐leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro

1998 • 18 citations

Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes

2001 • 18 citations

Lipoxins: novel anti-inflammatory therapeutics?

2000 • 18 citations

Study of mechanisms mediating contraction to leukotriene C4, D4 and other bronchoconstrictors on guinea pig trachea

1984 • 17 citations

Vascular and renal effects of leukotriene C4 in conscious rats

1985 • 17 citations

Some effects of leukotriene D₄ on the mechanical properties of the guinea‐pig basilar artery

1988 • 17 citations

Correlation between leukotriene D4-induced contraction and cytosolic calcium elevation: a quantitative and simultaneous evaluation in smooth muscle.

1994 • 17 citations

Characterization of distinct receptors for the peptidyl leukotrienes LTC4 and LTD4/LTE4 coupled to the same signaling pathway in isolated gastric muscle cells.

1993 • 16 citations

Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane

1998 • 16 citations

The bronchopulmonary pharmacology of SK&F 104353 in anesthetized guinea pigs: demonstration of potent and selective antagonism of responses to peptidoleukotrienes.

1989 • 16 citations

Characterization of the leukotriene B₄ receptor in porcine leukocytes

1999 • 15 citations

Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma

2002 • 15 citations

Binding sites for 3H-LTC4 in membranes from guinea pig ileal longitudinal muscle

1984 • 15 citations

Endothelial-dependent relaxation induced by leukotrienes C4, D4, and E4 in isolated canine arteries.

1988 • 15 citations

Comparative effects of leukotrienes on porcine pulmonary circulation in vitro and in vivo

1987 • 15 citations

Comparison of cutaneous and bronchial reactivity to leukotriene D4 in humans.

1986 • 14 citations

Comparison of cardiac and hemodynamic effects of plateletactivating factor-acether and leukotriene D4 in anesthetized dogs

1987 • 14 citations

Inhibition of leukotriene biosynthesis improves renal function in experimental glomerulonephritis

1995 • 14 citations

AN UNUSUAL TYPE OF HERNIA

1953 • 14 citations

A comparative study of PGI2 and two analogues (FCE 21292 and FCE 21258) in vitro and in vivo

1983 • 14 citations

Cell‐Cell Interactions in Lipoxin Generation and Characterization of Lipoxin A₄ Receptors^a

1994 • 13 citations

Specific binding of leukotriene C4 to endothelial cell membranes

1987 • 13 citations

Selective antagonism of peptidoleukotriene response does not reduce myocardial damage opr neutrophil accumulation following coronary artery occlusion with reperfusion

1989 • 13 citations

Characterisation of leukotriene receptors on rat lung strip

1994 • 13 citations

Characterization of specific binding sites for cysteinyl leukotrienes in sheep lung.

1994 • 12 citations

Leukotriene D4-induced vasoconstriction of coronary arteries in anaesthetized dogs

1984 • 12 citations

Antagonism of LTD4-evoked relaxation in canine renal artery and vein

1993 • 12 citations

Characteristics and distribution of specific binding sites for leukotriene C4 in human bronchi.

1987 • 11 citations

Quantitative Light Microscopic Autoradiographic Study on [³H]Leukotriene C₄Binding to Nonpregnant Bovine Uterine Tissue

1988 • 11 citations

Autoradiographic localization of leukotriene C4 and D4 binding sites in guinea-pig lung

1988 • 11 citations

Inhibition of leukotriene D4-induced coronary vasoconstriction by leukotriene antagonists in the anesthetized dog.

1987 • 11 citations

Regulation of topoisomerase I and II activities by cyclic nucleotide- and phospholipid-dependent protein kinases. Effects of interactions between the two transduction pathways.

1991 • 10 citations

LTA4-derived 5-oxo-eicosatetraenoic acid: pH-dependent formation and interaction with the LTB4 receptor of human polymorphonuclear leukocytes

2000 • 10 citations

Effects of leukotrienes B4, C4, and D4 on rat mesenteric microcirculation

1987 • 10 citations

Leukotrienes on porcine hemodynamics and prostanoid release

1985 • 9 citations

Effect of lipoxin B on colony-forming ability of human peripheral blood mononuclears in a diffusion chamber

1989 • 9 citations

Pharmacological comparison of L-serine borate and glutathione as inhibitors of metabolism of LTC4 to LTD4 by the isolated guinea pig trachea

1987 • 9 citations

Effects of Intracoronary Leukotriene D&lt;sub&gt;4&lt;/sub&gt; Infusion on the Coronary Circulation, Hemodynamics, and Prostanoid Release in Porcine Experiments

1987 • 8 citations

Competition of leukotrienes and ICI-198,615 for [3H]LTD4 binding sites in guinea pig lung membranes suggests the involvement of two LTD4 receptor subtypes.

1991 • 8 citations

Leukotriene C4 receptors in isolated brain capillaries.

1987 • 8 citations

High-affinity binding site for leukotriene C4 in human erythrocytes

1986 • 8 citations

The Presence of Leukotriene C4-Binding Sites in Bovine Corpora Lutea of Pregnancy

1988 • 7 citations

Specific binding of 3H-ICI 198, 615, a potent LTD4 antagonist, to guinea pig cardiac ventricular membranes

1990 • 7 citations

A Tale of Two CysLTs

2001 • 6 citations

Effect of ICI 198, 615, SK+F 104, 353, MK-571 and CGP45715A on cysteinyl leukotriene-induced responses in guinea-pig heart

1991 • 6 citations

Pharmacologic profile of chemically stable analogs of peptide leukotrienes

1987 • 6 citations

Evidence for leukotriene D4 receptors in guinea pig left atria.

1991 • 6 citations

Immediate hypersensitivity reactions of the heart: Reduction of tachycardia and arrhythmias by the SRS-A antagonist FPL 55712

1980 • 6 citations

[Effects of lipoxin B on colony-forming capacity of human peripheral blood mononuclear cells in diffusion chambers].

1989 • 5 citations

Contraction of guinea pig inferior vena cava by eicosanoids

1993 • 5 citations

MDL 28,753, an agonist of LTD4 but an antagonist of LTC4 in longitudinal muscle of guinea pig ileum.

1990 • 5 citations

Effects of exogeneous leukotrienes on the pulmonary circulation.

1985 • 5 citations

Evidence for leukotriene B4 receptors in human neutrophils.

1985 • 4 citations

Differential rank order of potency for antagonism of LTC4- and LTD4-induced contractions of Guinea pig trachea

1986 • 4 citations

Leukotriene D4 increases both the force of contraction and polyphosphoinositide formation in guinea-pig papillary muscle

1991 • 3 citations

Effects of arachidonic acid and bradykinin on the coronary flow, release of PGI2 and cardiac functions in the perfused guinea-pig heart.

1982 • 3 citations

Structural analysis of sulfido-peptide leukotrienes: application to the design of potent and specific antagonists of leukotriene D4.

1989 • 3 citations

Effect of Inhaled Leukotriene C₄on Cardiopulmonary Function

1989 • 3 citations

Enhanced synthesis and secretion of apolipoprotein E from sciatic nerves of streptozotocin-induced diabetic rats after injury

1988 • 2 citations

Metabolism of leukotriene B4 and related substances by polymorphonuclear leukocytes.

1989 • 2 citations

Cardiovascular and Sympathetic Effects of Leukotriene D₄in Renovascular and Spontaneously Hypertensive Rats

1984 • 2 citations

[Leukotriene C4 binding sites in the mouse forebrain: autoradiographic demonstration].

1986 • 1 citations

Deleted Work

1955 • 0 citations