Endostatin gene therapy enhances the efficacy of paclitaxel to suppress breast cancers and metastases in mice

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2005 • 17,966 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

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Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

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Hypersensitivity reactions from taxol.

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Estrogen and the Risk of Breast Cancer

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Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Antiangiogenesis in cancer therapy—endostatin and its mechanisms of action

2005 • 650 citations

Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by αvβ3 and α5β1 integrins

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Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor vascuiature induced by TNF and IFN-γ

1998 • 461 citations

Taxol: Mechanisms of Action and Resistancea

1986 • 415 citations

Endostatin's Antiangiogenic Signaling Network

2004 • 397 citations

Reduction of established spontaneous mammary carcinoma metastases following immunotherapy with major histocompatibility complex class II and B7.1 cell-based tumor vaccines.

1998 • 388 citations

Role of Inflammatory Mediators in Angiogenesis

2005 • 275 citations

Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis

2000 • 273 citations

Tumor Cells in Blood Shed From the Surgical Field

1995 • 269 citations

Consequences of angiogenesis for tumor progression, metastasis and cancer therapy

1995 • 243 citations

Angiostatin gene transfer: Inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest

1998 • 239 citations

Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells

2001 • 207 citations

Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer

2006 • 207 citations

Antiangiogenesis signals by endostatin

2001 • 198 citations

Endostatin Inhibits Human Tongue Carcinoma Cell Invasion and Intravasation and Blocks the Activation of Matrix Metalloprotease-2, -9, and -13

2003 • 164 citations

Aromatase inhibitors: mechanism of action and role in the treatment of breast cancer

2003 • 157 citations

Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapy

2001 • 144 citations

Does surgery modify growth kinetics of breast cancer micrometastases?

2001 • 122 citations

Endostatin: The logic of antiangiogenic therapy

2005 • 119 citations

Paclitaxel Enhances Macrophage IL-12 Production in Tumor-Bearing Hosts Through Nitric Oxide

1999 • 114 citations

Antitumor activity of endostatin against carcinogen-induced rat primary mammary tumors.

2000 • 95 citations

Endostatin, an antiangiogenic drug, induces tumor stabilization after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human high-grade non-Hodgkin lymphoma

2000 • 90 citations

Modelling approaches for angiogenesis

2004 • 89 citations

Synergistic effects of TNF-α and melphalan in an isolated limb perfusion model of rat sarcoma: a histopathological, immunohistochemical and electron microscopical study

1996 • 87 citations

E-selectin is required for the antiangiogenic activity of endostatin

2004 • 82 citations

Endostatin Exhibits a Direct Antitumor Effect in Addition to Its Antiangiogenic Activity in Colon Cancer Cells

2003 • 71 citations

Enhanced antitumour efficacy by combining conventional chemotherapy with angiostatin or endostatin in a liver metastasis model

2002 • 71 citations

Effects of paclitaxel on cytokine synthesis by unprimed human monocytes, T lymphocytes, and breast cancer cells

1998 • 69 citations

Unfulfilled Promise of Endostatin in a Gene Therapy-Xenotransplant Model of Human Acute Lymphocytic Leukemia

2002 • 59 citations

Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy

2006 • 58 citations

Continuous Intravascular Secretion of Endostatin in Mice from Transduced Hematopoietic Stem Cells

2002 • 56 citations

Alteration of lymphocyte microtubule assembly, cytotoxicity, and activation by the anticancer drug taxol.

1994 • 51 citations

Endostatin inhibits migration and invasion of head and neck squamous cell carcinoma cells.

2003 • 47 citations

Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein

2005 • 47 citations

Adeno-Associated Virus–Mediated Delivery of a Mutant Endostatin in Combination with Carboplatin Treatment Inhibits Orthotopic Growth of Ovarian Cancer and Improves Long-term Survival

2006 • 41 citations

Paclitaxel (Taxol) in Breast Cancer

1994 • 40 citations

Inhibition of Cytokine-Induced Microvascular Arrest of Tumor Cells by Recombinant Endostatin Prevents Experimental Hepatic Melanoma Metastasis

2004 • 38 citations

Taxol, a microtubule-stabilizing antineoplastic agent, differentially regulates normal and tumor-bearing host macrophage nitric oxide production

1997 • 32 citations

Synergistic activity of recombinant human endostatin in combination with adriamycin: analysis of in vitro activity on endothelial cells and in vivo tumor progression in an orthotopic murine mammary carcinoma model.

2003 • 32 citations

Antisense integrin αV and β3 gene therapy suppresses subcutaneously implanted hepatocellular carcinomas

2007 • 31 citations

Taxol-mediated changes in fibrosarcoma-induced immune cell function: Modulation of antitumor activities

1997 • 29 citations

Gene transfer of endostatin enhances the efficacy of doxorubicin to suppress human hepatocellular carcinomas in mice

2007 • 29 citations

Synergistic anti-tumor effect of recombinant human endostatin adenovirus combined with gemcitabine

2005 • 28 citations

Intramuscular delivery of antiangiogenic genes suppresses secondary metastases after removal of primary tumors

2004 • 28 citations

Low Dose Carboplatin Combined With Angiostatic Agents Prevents Metastasis in Human Testicular Germ Cell Tumor Xenografts

2003 • 28 citations

Concurrent delivery of GM‐CSF and endostatin genes by a single adenoviral vector provides a synergistic effect on the treatment of orthotopic liver tumors

2003 • 23 citations

Increased growth and incidence of lymph node metastases due to the angiogenesis inhibitor AGM-1470

1997 • 21 citations

Immune Response Against 3LL Lewis Lung Carcinoma Potentiates the Therapeutic Efficacy of Endostatin

2001 • 19 citations

Signal transduction mediated by endostatin directly modulates cellular function of lung cancer cells in vitro

2007 • 14 citations

Endostatin Expression by MDA-MB-435 Breast Cancer Cells Effectively Inhibits Tumor Growth

2003 • 12 citations

Electrogene therapy using endostatin, with or without suicide gene therapy, suppresses murine mammary tumor growth and metastasis

2006 • 10 citations

Plasmid DNA-induced cytokines together with cyclophosphamide decrease size and number of melanoma lung metastases.

2006 • 1 citations