Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

1990 • 1,002 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

The Transforming Growth Factor-βs

1991 • 882 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

TGF-β and fibrosis

1999 • 579 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Role of Transforming Growth Factor-beta Signaling in Cancer

2000 • 525 citations

Latent transforming growth factor-β: Structural features and mechanisms of activation

1997 • 511 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

The role for transforming growth factor-beta (TGF-beta) in human cancer.

1999 • 323 citations

Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency

1998 • 319 citations

Disruption of T Cell Homeostasis in Mice Expressing a T Cell–Specific Dominant Negative Transforming Growth Factor β II Receptor

2000 • 248 citations

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression.

1996 • 236 citations

Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis.

1999 • 221 citations

Pathobiology of the aging mouse

1996 • 213 citations

Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma.

1993 • 208 citations

Elevated Plasma Transforming Growth Factor-β1 Levels in Breast Cancer Patients Decrease After Surgical Removal of the Tumor

1995 • 207 citations

Critical steps in hematogenous metastasis: an overview.

2001 • 196 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

1999 • 188 citations

SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice.

1995 • 184 citations

Overexpression of E2F‐1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo

1998 • 167 citations

Critical Steps in Hematogenous Metastasis

2001 • 141 citations

A Soluble Transforming Growth Factor beta Receptor Expressed in Muscle Prevents Liver Fibrogenesis and Dysfunction in Rats

2000 • 138 citations

Gene therapy by transforming growth factor-β receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis

1999 • 132 citations

TGF-β in infections and infectious diseases

1999 • 125 citations

Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

1998 • 123 citations

TGF-β and cancer

1999 • 115 citations

Recombinant soluble transforming growth factor β type II receptor ameliorates radiation enteropathy in mice

2000 • 108 citations

Transforming growth factor-β and breast cancer: Mammary gland development

2000 • 77 citations

Manipulation of TGF-β to control autoimmune and chronic inflammatory diseases

1999 • 72 citations

Chimeric extracellular domain of type II transforming growth factor (TGF)‐β receptor fused to the Fc region of human immunoglobulin as a TGF‐β antagonist

1998 • 66 citations

Modulation of B16 Melanoma Growth and Metastasis by Anti-Transforming Growth Factor ?? Antibody and Interleukin-2

1996 • 59 citations

Aberrant TGF-β Production and Regulation in Metastatic Malignancy

1990 • 59 citations

Disassociation of Met-Mediated Biological Responses In Vivo: the Natural Hepatocyte Growth Factor/Scatter Factor Splice Variant NK2 Antagonizes Growth but Facilitates Metastasis

2000 • 58 citations

Soluble cytokine receptors: novel immunotherapeutic agents

2000 • 57 citations

TGF-β in the Cardiovascular System Molecular Mechanisms of a Context-Specific Growth Factor

2000 • 47 citations

Anti-(transforming growth factor ?) antibodies with predefined specificity inhibit metastasis of highly tumorigenic human xenotransplants in nu/nu mice

1995 • 36 citations

Reduction in transforming growth factor-β type II receptor in mouse lung carcinogenesis

1998 • 24 citations

Genetic and Immunologic Determinants of Age-Related and Virus-Induced Cardiopathy

1996 • 3 citations