Smad4 signalling in T cells is required for suppression of gastrointestinal cancer

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Stromal fibroblasts in cancer initiation and progression

2004 • 2,230 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

The role of IL-6 and STAT3 in inflammation and cancer

2005 • 923 citations

IL-13 Effector Functions

2003 • 910 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

Transforming growth factor-β in T-cell biology

2002 • 787 citations

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

2004 • 706 citations

Tissue- and site-specific DNA recombination in transgenic mice.

1992 • 651 citations

Cre-mediated gene deletion in the mammary gland

1997 • 504 citations

Context, tissue plasticity, and cancer

2005 • 470 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Persistent STAT3 Activation in Colon Cancer Is Associated with Enhanced Cell Proliferation and Tumor Growth

2005 • 397 citations

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling

2005 • 294 citations

IL-6 Signaling Promotes Tumor Growth in Colorectal Cancer

2004 • 242 citations

Role of Smad4 (DPC4) inactivation in human cancer

2003 • 242 citations

Generation of Smad4/Dpc4 conditional knockout mice

2002 • 228 citations

Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice.

1990 • 151 citations

Targeted Disruption of Smad4 in Mouse Epidermis Results in Failure of Hair Follicle Cycling and Formation of Skin Tumors

2005 • 107 citations

Role of Smad4 on TGF-β–induced extracellular matrix stimulation in mesangial cells

2003 • 100 citations

Squamous cell carcinoma and mammary abscess formation through squamous metaplasia inSmad4/Dpc4conditional knockout mice

2003 • 99 citations

Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium.

2000 • 95 citations

Common Deletion of SMAD4 in Juvenile Polyposis Is a Mutational Hotspot

2002 • 45 citations

Familial Juvenile Polyposis:Study of a Kindred: Evolution of Polyps and Relationship to Gastrointestinal Carcinoma

1994 • 43 citations