Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

1986 • 6,585 citations

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

1997 • 5,683 citations

Cancer nanotechnology: opportunities and challenges

2005 • 4,401 citations

Block copolymer micelles for drug delivery: design, characterization and biological significance

2001 • 3,413 citations

Polymer conjugates as anticancer nanomedicines

2006 • 1,894 citations

SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

2005 • 1,804 citations

Imaging of angiogenesis: from microscope to clinic

2003 • 990 citations

Tumor Vascular Permeability, Accumulation, and Penetration of Macromolecular Drug Carriers

2006 • 887 citations

Defective Angiogenesis in Mice Lacking Endoglin

1999 • 851 citations

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 • 823 citations

PDGF, TGF-β, and Heterotypic Cell–Cell Interactions Mediate Endothelial Cell–induced Recruitment of 10T1/2 Cells and Their Differentiation to a Smooth Muscle Fate

1998 • 789 citations

The two faces of transforming growth factor β in carcinogenesis

2003 • 740 citations

Preparation and Biological Characterization of Polymeric Micelle Drug Carriers with Intracellular pH-Triggered Drug Release Property: Tumor Permeability, Controlled Subcellular Drug Distribution, and Enhanced in Vivo Antitumor Efficacy

2004 • 716 citations

Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.

2003 • 593 citations

Tumoritropic and lymphotropic principles of macromolecular drugs.

1989 • 576 citations

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

2001 • 549 citations

Gastric Carcinoma

1995 • 538 citations

Development of TGF-β signalling inhibitors for cancer therapy

2004 • 536 citations

NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel

2005 • 534 citations

TGF-? receptor function in the endothelium

2004 • 502 citations

Arteriovenous malformations in mice lacking activin receptor-like kinase-1

2000 • 438 citations

Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

2000 • 433 citations

VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B–PDGFRβ signaling

2005 • 269 citations

Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer.

1996 • 243 citations

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

2003 • 231 citations

Inhibition of Pulmonary and Skeletal Metastasis by a Transforming Growth Factor-β Type I Receptor Kinase Inhibitor

2006 • 190 citations

TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cell–derived endothelial cells

2003 • 169 citations

Differential diagnosis of pancreatic tumors using ultrasound contrast imaging

2005 • 158 citations

Hereditary Hemorrhagic Telangiectasia, a Vascular Dysplasia Affecting the TGF- Signaling Pathway

2006 • 154 citations

Dose Dependency of Pharmacokinetics and Therapeutic Efficacy of Pegylated Liposomal Doxorubicin (DOXIL) in Murine Models

2002 • 152 citations

Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice

1996 • 109 citations

Molecular therapy in pancreatic adenocarcinoma

2004 • 71 citations

Liposomal encapsulated anthracyclines: new therapeutic horizons

2001 • 69 citations

The Blood Flow Characteristics in Borderline Ovarian Tumors Based on Both Color Doppler Ultrasound and Histopathological Analyses

1998 • 44 citations

Quantitative Assessment of Tumor Vasculature and Response to Therapy in Kaposi's Sarcoma Using Functional Noninvasive Imaging

2004 • 41 citations

Endogenous Tumor Necrosis Factor Inhibits the Cytotoxicity of Exogenous Tumor Necrosis Factor and Adriamycin in Pancreatic Carcinoma Cells

1996 • 23 citations