Minimal Effects on Immune Parameters Following Chronic Anti-TGF-β Monoclonal Antibody Administration to Normal Mice

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Current Protocols in Immunology

2001 • 641 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo

2000 • 403 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 375 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 326 citations

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

1995 • 275 citations

Disruption of T Cell Homeostasis in Mice Expressing a T Cell–Specific Dominant Negative Transforming Growth Factor β II Receptor

2000 • 248 citations

Transforming growth factor-beta directs IgA switching in human B cells.

1992 • 232 citations

Immune dysregulation in TGF-beta 1-deficient mice.

1994 • 231 citations

Bidirectional regulation of macrophage function by TGF-β

1999 • 208 citations

Characterization of monoclonal antibodies against Shiga-like toxin from Escherichia coli

1985 • 198 citations

SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice.

1995 • 184 citations

Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype.

1993 • 181 citations

Transforming Growth Factor β1 Inhibits Fas Ligand Expression and Subsequent Activation-induced Cell Death in T Cells via Downregulation of c-Myc

1999 • 177 citations

Regulation of TGF-β Response During T Cell Activation Is Modulated by IL-10

2001 • 173 citations

Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion.

1995 • 168 citations

The effect of TGF-β1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells

2000 • 154 citations

Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1.

1991 • 147 citations

Interferon Induces Natural Killer Cell Blastogenesis In Vivo

1984 • 116 citations

Requirement for Transforming Growth Factor β1 in Controlling T Cell Apoptosis

2001 • 116 citations

Further studies of the role of transforming growth factor-beta in human B cell function.

1989 • 108 citations

Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice.

1999 • 107 citations

TGF-β1: immunosuppressant and viability factor for T lymphocytes

1999 • 105 citations

Mouse Cell Surface Antigens: Nomenclature and Immunophenotyping

1998 • 105 citations

Partial IgA-Deficiency with Increased Th2-Type Cytokines in TGF-β1 Knockout Mice

1999 • 98 citations

Genetic Regulation of Autoimmune Disease: BALB/c Background TGF-β1-Deficient Mice Develop Necroinflammatory IFN-γ-Dependent Hepatitis

2001 • 90 citations

Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals.

1989 • 90 citations

Mechanisms of autoantibody production in autoimmune MRL mice.

1980 • 86 citations

A role for transforming growth factor-beta 1 in regulating natural killer cell and T lymphocyte proliferative responses during acute infection with lymphocytic choriomeningitis virus.

1991 • 80 citations

Regulation of Natural Killer Cell Activity by Transforming Growth Factor‐β and Prostaglandin E₂

1993 • 72 citations

TGF-β influences the life and death decisions of T lymphocytes

2000 • 70 citations

Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.

1999 • 66 citations

Autoimmune Sjögren's-like lesions in salivary glands of TGF-beta1-deficient mice are inhibited by adhesion-blocking peptides.

1996 • 63 citations

Opposing effects of TGF-beta 2 on the Th1 cell development of naive CD4+ T cells isolated from different mouse strains.

1995 • 60 citations

β2-Microglobulin-Deficient Background Ameliorates Lethal Phenotype of the TGF-β1 Null Mouse

1999 • 54 citations

Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture.

1995 • 49 citations

Role of the Sm antigen in the generation of anti-Sm autoantibodies in the SLE-prone MRL mouse.

1986 • 48 citations

Up-regulation of cytokine mRNA, adhesion molecule proteins, and MHC class II proteins in salivary glands of TGF-beta1 knockout mice: MHC class II is a factor in the pathogenesis of TGF-beta1 knockout mice.

1997 • 45 citations

Disruption of Transforming Growth Factor β Signaling by a Novel Ligand-dependent Mechanism

2002 • 41 citations

Naturally occurring antibodies to poly(ADP-ribose) in autoimmune MRL/Mp-lpr/lpr mice.

1985 • 25 citations

TGF-β1 differentially regulates IL-2 expression and [3H]-thymidine incorporation in CD3ε mAb- and CD28 mAb-activated splenocytes and thymocytes

2000 • 23 citations

Transforming growth factor β1 regulation of macrophage activation depends on the triggering stimulus

1993 • 23 citations

ENDOCRINE EXPRESSION OF THE ACTIVE FORM OF TGF-β1 IN THE TGF-β1 NULL MICE FAILS TO AMELIORATE LETHAL PHENOTYPE

2002 • 20 citations

The Three Isoforms of Transforming Growth Factor‐β Co‐stimulate Rat T Cells and Inhibit Lymphocyte Apoptosis

1998 • 16 citations

Immunoregulatory effects of transforming growth factor-β in a prolonged period of culture

1992 • 11 citations