Use of wild‐type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

1994 • 555 citations

Transfer of a foreign gene into the brain using adenovirus vectors

1993 • 538 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Comparative evaluation of several DNA binding dyes in the detection of apoptosis‐associated chromatin degradation by flow cytometry

1992 • 375 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.

1993 • 309 citations

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1993 • 305 citations

Frequent Mutations in the p53 Tumor Suppressor Gene in Human Leukemia T-Cell Lines

1990 • 296 citations

Development and Characterization of Recombinant Adenoviruses Encoding Human p53 for Gene Therapy of Cancer

1994 • 235 citations

Comparative Study of p53 Gene and Protein Alterations in Human Astrocytic Tumors

1993 • 229 citations

p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.

1993 • 229 citations

Detection of apoptosis of immature CD4+8+ thymocytes by flow cytometry

1991 • 226 citations

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors

1993 • 207 citations

Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions.

1992 • 200 citations

Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.

1990 • 195 citations

Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor

1991 • 97 citations

HISTOCHEMICAL STAINS FOR MACROPHAGES IN CELL SMEARS AND TISSUE SECTIONS: β-GALACTOSIDASE, ACID PHOSPHATASE, NONSPECIFIC ESTERASE, SUCCINIC DEHYDROGENASE, AND CYTOCHROME OXIDASE

1981 • 96 citations

Repression of the basal c-fos promoter by wild-type p53

1992 • 92 citations

Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene.

1992 • 70 citations

The utility of an antifos ribozyme in reversing cisplatin resistance in human carcinomas

1992 • 51 citations

The future of therapy for glioblastoma

1993 • 49 citations

Automated peak detection and cell cycle analysis of flow cytometric DNA histograms

1994 • 35 citations

Optimization of the L-M cell bioassay for quantitating tumor necrosis factor α in serum and plasma

1993 • 27 citations

Quantitative determination of the induction of apoptosis in a murine B cell line using flow cytometric bivariate cell cycle analysis

1992 • 22 citations