Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

1985 • 380 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Intermediate filament proteins in nonfilamentous structures: Transient disintegration and inclusion of subunit proteins in granular aggregates

1982 • 250 citations

Meth A fibrosarcoma cells express two transforming mutant p53 species.

1988 • 247 citations

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

1990 • 245 citations

p53 transformation-related protein: Detection by monoclonal antibody in mouse and human cells

1981 • 222 citations

Tumor suppressor genes

1990 • 179 citations

Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

1987 • 162 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.

1990 • 135 citations

Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells.

1985 • 128 citations

Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey COS cells.

1988 • 72 citations

The structural relationships between 54,000-molecular-weight cellular tumor antigens detected in viral- and nonviral-transformed cells

1981 • 55 citations

Stabilization of the p53 transformation-related protein in mouse fibrosarcoma cell lines: effects of protein sequence and intracellular environment.

1989 • 52 citations