Morphological and functional changes in cardiac myocytes isolated from mice overexpressing TNF-α

PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)

2000 • 1,940 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Matrix Metalloproteinases and Cardiovascular Disease

1995 • 873 citations

Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α

1997 • 830 citations

Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats

1998 • 810 citations

Mechanisms and Models in Heart Failure

1999 • 777 citations

Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.

1994 • 769 citations

Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

1993 • 708 citations

Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.

1992 • 656 citations

Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

1998 • 602 citations

Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy

1995 • 530 citations

Myosin isoenzyme redistribution in chronic heart overload

1979 • 524 citations

Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.

1990 • 486 citations

Myocyte Recovery After Mechanical Circulatory Support in Humans With End-Stage Heart Failure

1998 • 437 citations

Serum Soluble Heat Shock Protein 60 Is Elevated in Subjects With Atherosclerosis in a General Population

2000 • 437 citations

Congestive Heart Failure: Fifty Years of Progress

2000 • 435 citations

Alterations of calcium-regulatory proteins in heart failure

1998 • 432 citations

Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling

2000 • 426 citations

Myosin heavy chain gene expression in human heart failure.

1997 • 402 citations

Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca ²⁺ Uptake and Ca ²⁺ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing Hearts

1995 • 384 citations

Left Ventricular Remodeling in Transgenic Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor

2001 • 375 citations

Transcriptional Regulation During Cardiac Growth and Development

1993 • 371 citations

Tumor Necrosis Factor-α Provokes a Hypertrophic Growth Response in Adult Cardiac Myocytes

1997 • 364 citations

Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.

1993 • 359 citations

Control of Cardiac Gene Expression by Mechanical Stress

1993 • 343 citations

Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat.

1990 • 339 citations

Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor α can be modulated by anti-tumor necrosis factor α therapy

2000 • 319 citations

Four Kinetically Distinct Depolarization-activated K+ Currents in Adult Mouse Ventricular Myocytes

1999 • 309 citations

Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy.

1992 • 293 citations

Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.

1989 • 283 citations

Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload

1998 • 278 citations

Decreased Sarcoplasmic Reticulum Calcium Content Is Responsible for Defective Excitation-Contraction Coupling in Canine Heart Failure

2001 • 274 citations

Local control of excitation‐contraction coupling in rat heart cells.

1994 • 262 citations

Gender differences in molecular remodeling in pressure overload hypertrophy

1999 • 241 citations

Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.

1994 • 228 citations

Effects of gonadectomy and hormonal replacement on rat hearts.

1987 • 211 citations

Messenger RNA expression and immunological quantification of phospholamban and SR-Ca2+-ATPase in failing and nonfailing human hearts

2000 • 174 citations

Enhanced Na ⁺ -Ca ²⁺ Exchange in the Infarcted Heart

1997 • 164 citations

Cellular Mechanisms of Altered Contractility in the Hypertrophied Heart

1999 • 162 citations

Soluble Tumor Necrosis Factor Receptor Abrogates Myocardial Inflammation but Not Hypertrophy in Cytokine-Induced Cardiomyopathy

2000 • 159 citations

Method for isolation of adult mouse cardiac myocytes for studies of contraction and microfluorimetry

1996 • 137 citations

Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression

2000 • 137 citations

Superinhibition of Sarcoplasmic Reticulum Function by Phospholamban Induces Cardiac Contractile Failure

2001 • 131 citations

Effects of TNF-alpha on [Ca2+]i and contractility in isolated adult rabbit ventricular myocytes

1996 • 131 citations

Human heart failure: cAMP stimulation of SR Ca²⁺-ATPase activity and phosphorylation level of phospholamban

1999 • 125 citations

TNFα receptor expression in rat cardiac myocytes: TNFα inhibition of L‐type Ca²⁺ current and Ca²⁺ transients

1995 • 121 citations

Sarcoplasmic Reticulum Ca ²⁺ /Calmodulin-Dependent Protein Kinase Is Altered in Heart Failure

2000 • 106 citations

Effects of sex hormones on development of physiological and pathological cardiac hypertrophy in male and female rats

1990 • 101 citations

The pathophysiology of advanced heart failure

1998 • 98 citations

Anti–Tumor Necrosis Factor-α Antibody Limits Heart Failure in a Transgenic Model

2001 • 94 citations

Interleukin-1β Inhibits Phospholamban Gene Expression in Cultured Cardiomyocytes

1997 • 93 citations

Telomerase Activity in Rat Cardiac Myocytes is Age and Gender Dependent

2000 • 90 citations

Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy

2001 • 88 citations

Ca flux, contractility, and excitation-contraction coupling in hypertrophic rat ventricular myocytes

1998 • 81 citations

Maladaptive Remodeling of Cardiac Myocyte Shape Begins Long Before Failure in Hypertension

1998 • 75 citations

Calcium sequestration by the sarcoplasmic reticulum in heart failure

1998 • 49 citations

Suppression of protein degradation in progressive cardiac hypertrophy of chronic aortic regurgitation.

1993 • 40 citations

Gender-related differences in proliferative response of cardiac fibroblasts to hypoxia: effects of estrogen.

2000 • 37 citations

Intracellular calcium handling in isolated ventricular myocytes from cardiomyopathic hamsters (strain BIO 14.6) with congestive heart failure

1994 • 27 citations

Role of nitric oxide and platelet-activating factor in cardiac alterations induced by tumor necrosis factor-α in the guinea-pig papillary muscle

1999 • 26 citations

Left Ventricular Filling in Ischemic and Hypertrophic Heart Disease

1987 • 12 citations