Sarcoplasmic Reticulum Ca 2+ /Calmodulin-Dependent Protein Kinase Is Altered in Heart Failure

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1988 • 1,048 citations

Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.

1994 • 769 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy

1995 • 530 citations

Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity

1991 • 499 citations

Advances in second messenger and phosphoprotein research

1992 • 481 citations

Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylations

1979 • 454 citations

Protein phosphatases: recent progress.

1991 • 391 citations

Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca ²⁺ Uptake and Ca ²⁺ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing Hearts

1995 • 384 citations

Identification and Expression of δ-Isoforms of the Multifunctional Ca ²⁺ /Calmodulin-Dependent Protein Kinase in Failing and Nonfailing Human Myocardium

1999 • 311 citations

Phosphorylation Modulates the Function of the Calcium Release Channel of Sarcoplasmic Reticulum from Cardiac Muscle

1995 • 286 citations

Reduced Ca2+-Sensitivity of SERCA 2a in Failing Human Myocardium due to Reduced Serin-16 Phospholamban Phoshorylation

1999 • 282 citations

Increased Expression of Cardiac Phosphatases in Patients with End-stage Heart Failure

1997 • 262 citations

Impaired Cardiac Performance in Heterozygous Mice with a Null Mutation in the Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 (SERCA2) Gene

1999 • 261 citations

Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts

1999 • 243 citations

Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban

1991 • 226 citations

Contribution of Abnormal Sarcoplasmic Reticulum ATPase Activity to Systolic and Diastolic Dysfunction in Human Heart Failure

1998 • 209 citations

Differential Changes in Cardiac Phospholamban and Sarcoplasmic Reticular Ca ²⁺ -ATPase Protein Levels

1995 • 196 citations

Molecular mechanism of regulation of Ca2+ pump ATPase by phospholamban in cardiac sarcoplasmic reticulum. Effects of synthetic phospholamban peptides on Ca2+ pump ATPase.

1992 • 184 citations

Phosphorylation and activation of the Ca(2+)-pumping ATPase of cardiac sarcoplasmic reticulum by Ca2+/calmodulin-dependent protein kinase.

1993 • 163 citations

The effect of Ca²⁺–calmodulin‐dependent protein kinase II on cardiac excitation–contraction coupling in ferret ventricular myocytes

1997 • 162 citations

Alterations in sarcoplasmic reticulum function and gene expression in ischemic-reperfused rat heart

1999 • 137 citations

Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase

1994 • 136 citations

cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium

1994 • 134 citations

Human heart failure: cAMP stimulation of SR Ca²⁺-ATPase activity and phosphorylation level of phospholamban

1999 • 125 citations

The max of the Ca2+-ATPase of Cardiac Sarcoplasmic Reticulum (SERCA2a) Is Not Altered by Ca2+/Calmodulin-dependent Phosphorylation or by Interaction with Phospholamban

1996 • 124 citations

Sarcoplasmic reticulum calcium pump in cardiac and slow twitch skeletal muscle but not fast twitch skeletal muscle undergoes phosphorylation by endogenous and exogenous Ca2+/calmodulin-dependent protein kinase. Characterization of optimal conditions for calcium pump phosphorylation.

1994 • 114 citations

Modification of ischemia-reperfusion-induced changes in cardiac sarcoplasmic reticulum by preconditioning

1998 • 111 citations

Purified, Reconstituted Cardiac Ca2+-ATPase Is Regulated by Phospholamban but Not by Direct Phosphorylation with Ca2+/Calmodulin-dependent Protein Kinase

1996 • 106 citations

Regulation of cardiac sarcoplasmic reticulum calcium transport by calcium-calmodulin-dependent phosphorylation.

1983 • 104 citations

Differential changes in left and right ventricular SR calcium transport in congestive heart failure

1992 • 101 citations

Regulation of calcium transport by protein phosphatase activity associated with cardiac sarcoplasmic reticulum.

1985 • 100 citations

Calcium/calmodulin-dependent protein kinase II: role in learning and memory

1993 • 83 citations

Phospholamban-mediated stimulation of Ca2+ uptake in sarcoplasmic reticulum from normal and failing hearts.

1990 • 80 citations

Phosphorylation of the purified cardiac ryanodine receptor by exogenous and endogenous protein kinases

1993 • 79 citations

Cardiac protein phosphorylation: functional and pathophysiological correlates

1998 • 78 citations

Sarcolemmal calcium transport in congestive heart failure due to myocardial infarction in rats

1992 • 76 citations

Status of Ca²⁺/calmodulin protein kinase phosphorylation of cardiac SR proteins in ischemia-reperfusion

1999 • 76 citations

Pathophysiology of cardiac dysfunction in congestive heart failure.

1993 • 65 citations

Enhanced triglyceride clearance with intraperitoneal human acylation stimulating protein in C57BL/6 mice

1999 • 62 citations

The cardiac sarcoplasmic reticulum phospholamban kinase is a distinct δ‐CaM kinase isozyme

1995 • 58 citations

Ca2+/Calmodulin-Dependent Phosphorylation of the Ca2+-ATPase, Uncoupled from Phospholamban, Stimulates Ca2+-Pumping in Native Cardiac Sarcoplasmic Reticulum

1999 • 52 citations

Abnormal intracellular calcium handling in acute and chronic heart failure: role in systolic and diastolic dysfunction

1990 • 46 citations

Protein phosphorylation and dephosphorylation

1990 • 40 citations

Protein Phosphorylation and Dephosphorylation in Physiologic and Oncologic Processes

1996 • 40 citations

Captopril Treatment Improves the Sarcoplasmic Reticular Ca2+Transport in Heart Failure Due to Myocardial Infarction

1999 • 37 citations

Phosphorylation and dephosphorylation of protein in regulating cellular function

1994 • 33 citations

Autoactivation of calmodulin-dependent protein kinase II by autophosphorylation.

1991 • 32 citations

Sarcoplasmic reticulum Ca-release channel and ATP-synthesis activities are early myocardial markers of heart failure produced by rapid ventricular pacing in dogs

1994 • 32 citations

Anti-phospholamban and protein kinase A alter the Ca2+ sensitivity and maximum velocity of Ca2+ uptake by the cardiac sarcoplasmic reticulum

1998 • 28 citations

Ontogeny of Sarcoplasmic Reticulum Protein Phosphorylation by Ca2+–Calmodulin-dependent Protein Kinase

1997 • 25 citations

Divergent Effects of Ruthenium Red and Ryanodine on Ca2+/Calmodulin-Dependent Phosphorylation of the Ca2+Release Channel (Ryanodine Receptor) in Cardiac Sarcoplasmic Reticulum

1996 • 23 citations

Cardiac Sarcoplasmic Reticular Function in Rats with Chronic Heart Failure Following Myocardial Infarction

1997 • 22 citations

Serine Phosphorylation of the Sarcoplasmic Reticulum Ca2+-ATPase in the Intact Beating Rabbit Heart

1999 • 21 citations

Role of endocardium in cardiac overloading and failure

1990 • 18 citations

Sarcoplasmic reticular Ca2+ pump ATPase activity in congestive heart failure due to myocardial infarction.

1996 • 11 citations

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