Human heart failure: cAMP stimulation of SR Ca2+-ATPase activity and phosphorylation level of phospholamban

[31] Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands

1988 • 1,048 citations

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

1987 • 923 citations

Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.

1994 • 769 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 696 citations

Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.

1987 • 500 citations

Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.

1990 • 486 citations

Phosphorylation of the Sarcoplasmic Reticulum and Sarcolemma

1982 • 441 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 407 citations

Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca ²⁺ Uptake and Ca ²⁺ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing Hearts

1995 • 384 citations

Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.

1993 • 359 citations

Phospholamban: A Prominent Regulator of Myocardial Contractility

1996 • 346 citations

Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.

1996 • 319 citations

Role of intracellular calcium handling in force-interval relationships of human ventricular myocardium.

1990 • 276 citations

In Vivo Echocardiographic Detection of Enhanced Left Ventricular Function in Gene-Targeted Mice With Phospholamban Deficiency

1995 • 241 citations

Expression of A-, B-, and C-type natriuretic peptide genes in failing and developing human ventricles. Correlation with expression of the Ca(2+)-ATPase gene.

1992 • 231 citations

Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.

1994 • 228 citations

Contribution of Abnormal Sarcoplasmic Reticulum ATPase Activity to Systolic and Diastolic Dysfunction in Human Heart Failure

1998 • 209 citations

Messenger RNA expression and immunological quantification of phospholamban and SR-Ca2+-ATPase in failing and nonfailing human hearts

2000 • 174 citations

Molecular and physiological alterations in murine ventricular dysfunction.

1994 • 160 citations

Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts

1996 • 159 citations

cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium

1994 • 134 citations

Amino acids Lys-Asp-Asp-Lys-Pro-Val402 in the Ca(2+)-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban.

1994 • 132 citations

Effect of inotropic stimulation on the negative force-frequency relationship in the failing human heart.

1993 • 125 citations

Adenoviral Gene Transfer of Phospholamban in Isolated Rat Cardiomyocytes

1997 • 122 citations

Phospholamban Gene Dosage Effects in the Mammalian Heart

1996 • 118 citations

Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy

1996 • 115 citations

Myocardial force-frequency defect in mitral regurgitation heart failure is reversed by forskolin.

1993 • 109 citations

[4] Isolation of sarcoplasmic reticulum fractions referable to longitudinal tubules and functional terminal cisternae from rabbit skeletal muscle

1988 • 90 citations

The physical mechanism of calcium pump regulation in the heart

1994 • 87 citations

Phospholamban-mediated stimulation of Ca2+ uptake in sarcoplasmic reticulum from normal and failing hearts.

1990 • 80 citations

Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts

1996 • 74 citations

Post-extrasystolic potentiation and the force-frequency relationship: Differential augmentation of myocardial contractility in working myocardium from patients with end-stage heart failure

1990 • 63 citations

Myocardial Ca2+- and ATP-cycling imbalances in end-stage dilated and ischemic cardiomyopathies

1995 • 34 citations

[Plasticity of myocardial phenotype during cardiac hypertrophy and failure].

1993 • 5 citations

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