Soluble Tumor Necrosis Factor Receptor Abrogates Myocardial Inflammation but Not Hypertrophy in Cytokine-Induced Cardiomyopathy

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.

1993 • 837 citations

Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α

1997 • 830 citations

Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats

1998 • 810 citations

Tumor necrosis factor.

1992 • 601 citations

Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE.

1990 • 500 citations

Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.

1989 • 493 citations

Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.

1990 • 486 citations

Safety and Efficacy of a Soluble P75 Tumor Necrosis Factor Receptor (Enbrel, Etanercept) in Patients With Advanced Heart Failure

1999 • 397 citations

Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches.

1989 • 308 citations

Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.

1994 • 220 citations

Selective gene expression in failing human heart. Quantification of steady-state levels of messenger RNA in endomyocardial biopsies using the polymerase chain reaction.

1991 • 199 citations

Myocarditis induced by targeted expression of the MCP-1 gene in murine cardiac muscle.

1998 • 196 citations

Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.

1990 • 175 citations

Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice

1997 • 161 citations

Molecular and physiological alterations in murine ventricular dysfunction.

1994 • 160 citations

Therapeutic effect of anti-tumor necrosis factor-alpha antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus.

1994 • 160 citations

Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis.

1992 • 131 citations

Increased Myocardial Tumor Necrosis Factor-α in a Crystalloid-Perfused Model of Cardiac Ischemia-Reperfusion Injury

1998 • 115 citations

Adenovirus-Mediated Blockade Of Tumor Necrosis Factor In Mice Protects Against Endotoxic Shock Yet Impairs Pulmonary Host Defense

1995 • 98 citations

Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis.

1992 • 94 citations

Interleukin-1β Inhibits Phospholamban Gene Expression in Cultured Cardiomyocytes

1997 • 93 citations

Soluble TNF binding proteins modulate the negative inotropic properties of TNF-alpha in vitro

1995 • 90 citations

Evidence for a protective role of tumor necrosis factor in the acute phase of Trypanosoma cruzi infection in mice

1997 • 74 citations

End-systolic Pressure–Dimension Relationship ofin situMouse Left Ventricle

1998 • 21 citations

Reversibility of load-induced changes in myosin heavy chain gene expression

1992 • 14 citations

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