Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Human tumor necrosis factor. Production, purification, and characterization.

1985 • 922 citations

Adrenergic effects on the biology of the adult mammalian cardiocyte.

1992 • 873 citations

A patch‐clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine.

1982 • 820 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.

1989 • 567 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.

1989 • 493 citations

Phase I study of recombinant tumor necrosis factor in cancer patients.

1987 • 430 citations

Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.

1987 • 425 citations

Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failure.

1991 • 348 citations

Recombinant Human Tumor Necrosis Factor Administered as a 24-Hour Intravenous Infusion. A Phase I and Pharmacologic Study

1988 • 310 citations

The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.

1987 • 295 citations

Mediation of Cardioprotection by Transforming Growth Factor-β

1990 • 292 citations

Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-alpha in conscious dogs.

1992 • 275 citations

Acute in vivo effects of human recombinant tumor necrosis factor.

1987 • 256 citations

Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages.

1992 • 248 citations

Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin

1992 • 237 citations

Mechanism of cytokine inhibition of beta-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction.

1990 • 215 citations

Load regulation of the properties of adult feline cardiocytes: growth induction by cellular deformation.

1989 • 206 citations

Tumour necrosis factor in man: Clinical and biological observations

1987 • 205 citations

Cell cultures of adult cardiomyocytes as models of the myocardium

1986 • 173 citations

Circulating tumour necrosis factor‐α (cachectin) in myocardial infarction

1989 • 172 citations

Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis.

1992 • 131 citations

A video system for measuring motion in contracting heart cells

1988 • 124 citations

Calcium currents in normal and hypertrophied isolated feline ventricular myocytes

1988 • 117 citations

Tumor necrosis factor challenges in canines: patterns of cardiovascular dysfunction

1992 • 110 citations

Prolonged exposure of rat aorta to low levels of endotoxin in vitro results in impaired contractility. Association with vascular cytokine release.

1990 • 102 citations

Cellular versus myocardial basis for the contractile dysfunction of hypertrophied myocardium.

1991 • 89 citations

Expression of tumor necrosis factor in human acute cardiac rejection. An immunohistochemical and immunoblotting study.

1991 • 88 citations

Ultrastructure of terminally differentiated adult rat cardiac muscle cells in culture

1982 • 56 citations

Cardiac Muscle Cell Proliferation and Cell Differentiation in Vivo and in Vitro

1983 • 54 citations

A new method for assessment of cultured cardiac myocyte contractility detects immune factor-mediated inhibition of beta-adrenergic responses.

1991 • 51 citations

G-protein-mediated regulation of a Ca2+-dependent K+ channel in cultured vascular endothelial cells

1992 • 48 citations

Myocardial dysfunction and coronary vasoconstriction induced by platelet-activating factor in the post-infarcted rabbit isolated heart

1988 • 37 citations

Continuous infusion of tumor necrosis factor: Mechanisms of toxicity in the rat

1988 • 37 citations

Recombinant human tumour necrosis factor increases cytosolic free calcium in murine fibroblasts and stimulates inositol phosphate formation in L-M and arachidonic acid release in 3T3 cells

1990 • 21 citations

Effects of tumor necrosis factor (TNF) on lipolytic activities of rat heart

1988 • 12 citations

Transmembrane potassium fluxes in isolated feline ventricular myocytes

1985 • 9 citations

Deleted Work

1955 • 0 citations