Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Apoptosis in the Failing Human Heart

1997 • 1,690 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)

1996 • 1,203 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

TUMOR NECROSIS FACTOR: A Pleiotropic Cytokine and Therapuetic Target

1994 • 1,047 citations

Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

1996 • 993 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum.

1996 • 770 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.

1985 • 620 citations

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.

1989 • 567 citations

Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart Failure

1995 • 534 citations

Increased circulating cytokines in patients with myocarditis and cardiomyopathy.

1994 • 525 citations

Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration.

1995 • 436 citations

Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization

1994 • 423 citations

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.

1995 • 407 citations

Cytokine mRNA expression in postischemic/reperfused myocardium.

1995 • 375 citations

Basic Mechanisms in Congestive Heart Failure

1994 • 365 citations

Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy

1996 • 365 citations

Tumor Necrosis Factor-α Provokes a Hypertrophic Growth Response in Adult Cardiac Myocytes

1997 • 364 citations

Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failure.

1991 • 348 citations

Expression and Functional Significance of Tumor Necrosis Factor Receptors in Human Myocardium

1995 • 348 citations

Isolation and characterization of the mouse cardiac myosin heavy chain genes

1991 • 331 citations

Hemodynamic Regulation of Tumor Necrosis Factor-α Gene and Protein Expression in Adult Feline Myocardium

1997 • 284 citations

Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-alpha in conscious dogs.

1992 • 275 citations

Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock.

1986 • 260 citations

The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.

1992 • 228 citations

Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation.

1994 • 219 citations

Role of endotoxemia in cardiovascular dysfunction and mortality. Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock.

1989 • 217 citations

Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.

1990 • 175 citations

Circulating tumour necrosis factor‐α (cachectin) in myocardial infarction

1989 • 172 citations

A Circulating Myocardial Depressant Substance is Associated with Cardiac Dysfunction and Peripheral Hypoperfusion (Lactic Acidemia) in Patients with Septic Shock

1989 • 166 citations

Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice

1997 • 161 citations

Increased secretion of tumor necrosis factor-alpha and interferon-gamma by mononuclear leukocytes in patients with ischemic heart disease. Relevance in superoxide anion generation.

1994 • 160 citations

Cytokines in Acute Myocardial Infarction

1994 • 149 citations

Tumor Necrosis Factor-α Induces a Biphasic Effect on Myocardial Contractility in Conscious Dogs

1996 • 133 citations

Mechanism of the Tumor Necrosis Factor α-mediated Induction of Endothelial Tissue Factor

1995 • 125 citations

Circulating endotoxin and tumor necrosis factor during pediatric cardiac surgery

1992 • 116 citations

TNF but not IL-1 in dogs causes lethal lung injury and multiple organ dysfunction similar to human sepsis

1991 • 75 citations

Cellular mechanisms of endotoxin-induced myocardial depression in rabbits.

1993 • 74 citations

Effects of E. coli endotoxemia on ventricular performance

1966 • 72 citations

Anti-tumor necrosis factor-alpha prevents decreased ventricular contractility in endotoxemic pigs.

1995 • 69 citations

Both tumor necrosis factor receptors, TNFR60 and TNFR80, are involved in signaling endothelial tissue factor expression by juxtacrine tumor necrosis factor alpha

1995 • 62 citations

Cytokines in Acute Myocardial Infarction

1994 • 54 citations

Tumor necrosis factor-α causes myocardial depression in guinea pigs

1992 • 50 citations

Tumor Necrosis Factor and Cardiac Function

1992 • 44 citations

Cytokines and the heart : molecular mechanisms of septic cardiomyopathy

1996 • 39 citations

REPEATED ADMINISTRATION OF A F(ab′)2 FRAGMENT OF AN ANTI-TUMOR NECROSIS FACTOR α MONOCLONAL ANTIBODY IN PATIENTS WITH SEVERE SEPSIS

1994 • 37 citations

Cardiotrophin-1 inhibits tumor necrosis factor production in the heart and serum of lipopolysaccharide-treated mice and in vitro in mouse blood cells.

1996 • 34 citations

Left ventricular performance during continuous endotoxin-induced hyperdynamic endotoxemia in sheep

1993 • 32 citations

Cytokine Induction During Cardiac Surgery: Analysis of TNF-? Expression Pre-and Postcardiopulmonary Bypass

1995 • 32 citations

Reduction of intrinsic contractile reserves of the left ventricle by Escherichia coli endotoxin shock in guinea-pigs

1985 • 24 citations

CONTRACTILE DYSFUNCTION OF VENTRICULAR MYOCYTES ISOLATED FROM ENDOTOXEMIC GUINEA PIGS

1994 • 21 citations

Effects of transforming growth factor-beta 1 on nitric oxide synthesis by C2C12 skeletal myocytes

1996 • 8 citations

SEPTIC CARDIOMYOPATHY

1997 • 4 citations

Treatment of sepsis

1992 • 4 citations