Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Isolation of High‐Molecular‐Weight DNA from Mammalian Cells

1973 • 1,723 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)

1996 • 1,203 citations

Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

1996 • 993 citations

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

1987 • 923 citations

Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.

1985 • 833 citations

Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

1993 • 708 citations

Tumor necrosis factor.

1991 • 568 citations

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.

1988 • 545 citations

Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart Failure

1995 • 534 citations

Increased circulating cytokines in patients with myocarditis and cardiomyopathy.

1994 • 525 citations

Circulating Levels of Cytokines and Their Endogenous Modulators in Patients With Mild to Severe Congestive Heart Failure Due to Coronary Artery Disease or Hypertension

1996 • 505 citations

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

1991 • 479 citations

Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration.

1995 • 436 citations

Transthoracic Echocardiography in Models of Cardiac Disease in the Mouse

1996 • 372 citations

Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy

1996 • 365 citations

Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failure.

1991 • 348 citations

Expression and Functional Significance of Tumor Necrosis Factor Receptors in Human Myocardium

1995 • 348 citations

Isolation and characterization of the mouse cardiac myosin heavy chain genes

1991 • 331 citations

Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac G _sα Overexpression

1996 • 266 citations

Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression

1985 • 266 citations

In Vivo Echocardiographic Detection of Enhanced Left Ventricular Function in Gene-Targeted Mice With Phospholamban Deficiency

1995 • 241 citations

INTERCELLULAR ADHESION MOLECULE 1 ON LIVER ALLOGRAFTS DURING REJECTION

1989 • 238 citations

The Structure of Rat Preproatrial Natriuretic Factor as Defined by a Complementary DNA Clone

1984 • 233 citations

The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.

1992 • 228 citations

The Cardiomyopathy of Overload: An Unnatural Growth Response in the Hypertrophied Heart

1994 • 218 citations

Echocardiographic Assessment of Left Ventricular Mass and Systolic Function in Mice

1995 • 217 citations

Circulating Interleukin-6 in Severe Heart Failure

1997 • 211 citations

Tumour necrosis factor alpha in severe congestive cardiac failure.

1993 • 172 citations

Cachectin (Tumor Necrosis Factor)

1988 • 170 citations

Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice

1997 • 161 citations

Endotoxin and Cytokines Induce Direct Cardiodepressive Effects in Mammalian Cardiomyocytes via Induction of Nitric Oxide Synthase

1996 • 157 citations

Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-Alpha in Myocardium in Human Dilated Cardiomyopathy

1997 • 143 citations

In vivo assessment of LV mass in mice using high-frequency cardiac ultrasound: necropsy validation

1994 • 135 citations

Effects of TNF-alpha on [Ca2+]i and contractility in isolated adult rabbit ventricular myocytes

1996 • 131 citations

Cardiac MRI of the normal and hypertrophied mouse heart

1998 • 114 citations

Coexistence of sudden cardiac death and end-stage heart failure in familial hypertrophic cardiomyopathy

1993 • 73 citations

Nucleotide sequence of the murine TNF locus, including the TNF-α (tumor necrosis factor) and TNF-β (lymphotoxin) genes

1987 • 69 citations

Tumor necrosis factor α up-regulates Giα and Gß proteins and adenylyl cyclase responsiveness in rat cardiomyocytes

1991 • 64 citations

INDUCTION OF TNFα AND TNFβ GENE EXPRESSION IN RAT CARDIAC TRANSPLANTS DURING ALLOGRAFT REJECTION

1993 • 62 citations

Atrial natriuretic peptide transcription, storage, and release in rats with myocardial infarction

1987 • 57 citations

Tumour necrosis factor is expressed in cardiac tissues of patients with heart failure

1996 • 52 citations

Idiopathic Hypertrophic Cardiomyopathy in Identical Twins

1992 • 21 citations

Tumor necrosis factor is expressed in cardiac tissues of patients with heart failure

1996 • 7 citations