TGF-β in the Cardiovascular System Molecular Mechanisms of a Context-Specific Growth Factor

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

CREB-binding protein/p300 are transcriptional coactivators of p65

1997 • 819 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Silencing of TGF-β signalling by the pseudoreceptor BAMBI

1999 • 691 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

1998 • 469 citations

Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

1999 • 433 citations

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300

1997 • 428 citations

The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis

1995 • 386 citations

Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype

1999 • 384 citations

Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice

1994 • 363 citations

Biomechanical activation: an emerging paradigm in endothelial adhesion biology.

1997 • 348 citations

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

1997 • 325 citations

Endoglin modulates cellular responses to TGF-beta 1.

1996 • 306 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene

1998 • 288 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer

1998 • 230 citations

Overexpression of transforming growth factor β1 in arterial endothelium causes hyperplasia, apoptosis, and cartilaginous metaplasia

1998 • 180 citations

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells

1998 • 179 citations

Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells.

1997 • 175 citations

MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells

1999 • 171 citations

Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells.

1997 • 171 citations

Targeted deletion of Smad4 shows it is required for transforming growth factor β and activin signaling in colorectal cancer cells

1998 • 158 citations

Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease): new insights in pathogenesis, complications, and treatment.

1996 • 154 citations

Vascular Cell Apoptosis

1999 • 149 citations

In Vivo Effect of TGF-β1

1995 • 124 citations

From receptor to nucleus: the Smad pathway

1997 • 110 citations

TGF-β Receptors and Signalling Mechanisms

1998 • 86 citations

Serum levels of the TGF-beta receptor are increased in atherosclerosis

1996 • 73 citations

Immunolocalization of BMP-6, a novel TGF-β-related cytokine, in normal and atherosclerotic smooth muscle cells

1995 • 55 citations

A PIVOTAL ROLE FOR TGF‐β* IN ATHEROGENESIS?

1995 • 54 citations

REGULATION AND INTERACTIONS OF TRANSFORMING GROWTH FACTOR‐β WITH CARDIOVASCULAR CELLS: IMPLICATIONS FOR DEVELOPMENT AND DISEASE

1996 • 45 citations

Transforming growth factor-? proliferated vascular smooth muscle cells from spontaneously hypertensive rats

1995 • 16 citations

TGF-beta: implications for human vascular disease.

1995 • 13 citations

Deleted Work

1955 • 0 citations