TGF-β in infections and infectious diseases

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis.

1997 • 510 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Interleukin 10 production correlates with pathology in human Leishmania donovani infections.

1993 • 445 citations

Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism

1992 • 439 citations

The Leishmaniases in biology and medicine

1987 • 390 citations

Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection.

1992 • 364 citations

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

1985 • 321 citations

Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta).

1991 • 309 citations

Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major.

1994 • 302 citations

Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions.

1995 • 265 citations

In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections.

1988 • 256 citations

Influenza virus neuraminidase activates latent transforming growth factor beta

1996 • 246 citations

Restoration of IFN-gamma production and lymphocyte proliferation in visceral leishmaniasis.

1994 • 224 citations

Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis.

1993 • 217 citations

Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma.

1987 • 215 citations

Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon gamma production.

1996 • 212 citations

IL-10 mediates susceptibility to Trypanosoma cruzi infection.

1994 • 199 citations

Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection.

1990 • 194 citations

Transforming Growth Factor β Production Is Inversely Correlated with Severity of Murine Malaria Infection

1998 • 193 citations

Selective induction of transforming growth factor beta in human monocytes by lipoarabinomannan of Mycobacterium tuberculosis

1996 • 176 citations

Enhancement Of Intracellular Growth Of Mycobacterium Tuberculosis In Human Monocytes by Transforming Growth Factor- l

1994 • 172 citations

Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis.

1996 • 167 citations

Increased expression of proinflammatory cytokines in chronic lesions of human cutaneous leishmaniasis

1994 • 166 citations

Trypanosome invasion of mammalian cells requires activation of the TGFβ signaling pathway

1995 • 158 citations

Transforming growth factor‐β inhibits interleukin‐12‐induced production of interferon‐γ by natural killer cells: A role for transforming growth factor‐β in the regulation of T cell‐independent resistance to Toxoplasma gondii

1995 • 149 citations

In vitrorestoration of T cell responses in tuberculosis and augmentation of monocyte effector function againstMycobacterium tuberculosisby natural inhibitors of transforming growth factor β

1997 • 148 citations

Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1.

1991 • 147 citations

Human cytomegalovirus infection induces transcription and secretion of transforming growth factor beta 1

1994 • 146 citations

The importance of TGF-beta in murine visceral leishmaniasis.

1998 • 141 citations

Plasmid DNA encoding transforming growth factor-beta1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model.

1998 • 134 citations

IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages.

1994 • 134 citations

Production of transforming growth factor-beta by Mycobacterium avium-infected human macrophages is associated with unresponsiveness to IFN-gamma.

1993 • 133 citations

Transforming growth factor‐ß₁ in chronic hepatitis C

1997 • 133 citations

Cytokines and cytokine therapies in HIV infection.

1997 • 127 citations

Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production.

1999 • 122 citations

The Importance of TGF-β in Murine Visceral Leishmaniasis

1998 • 117 citations

TGF-β: A Balancing Act

1998 • 116 citations

Altered Cytokine Production and Impaired Antimycobacterial Immunity in Protein-Malnourished Guinea Pigs

1998 • 103 citations

Anti-TGF-β Treatment Promotes Rapid Healing ofLeishmania majorInfection in Mice by Enhancing In Vivo Nitric Oxide Production

1999 • 96 citations

TGF-beta is important in determining the in vivo patterns of susceptibility or resistance in mice infected with Candida albicans.

1995 • 93 citations

Transforming growth factor-beta in human cutaneous leishmaniasis.

1995 • 90 citations

Effects of cytokines on multiplication of Toxoplasma gondii in microglial cells.

1993 • 90 citations

Transforming growth factor-beta and suppression of humoral immune responses in HIV infection.

1991 • 84 citations

Interleukin-12-stimulated natural killer cells can activate human macrophages to inhibit growth of Mycobacterium avium

1995 • 84 citations

Increased levels of interferon-gamma (IFN-γ), IL-4 and transforming growth factor-beta (TGF-β) mRNA expressing blood mononuclear cells in human HIV infection

1994 • 80 citations

In vitro effect of transforming growth factor-beta on progression of HIV-1 infection in primary mononuclear phagocytes.

1991 • 77 citations

Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors

1993 • 77 citations

Induction of transforming growth factor beta 1 by purified protein derivative of Mycobacterium tuberculosis

1995 • 74 citations

TGFβ and HIV Infectiona

1993 • 74 citations

Transforming Growth Factor β and Immunosuppression in Experimental Visceral Leishmaniasis

1998 • 73 citations

Parainfluenza virus-induced persistence of airway inflammation, fibrosis, and dysfunction associated with TGF-beta 1 expression in brown Norway rats.

1996 • 73 citations

Production of TNF-alpha, IL-6 and TGF-beta, and expression of receptors for TNF-alpha and IL-6, during murine Mycobacterium avium infection.

1995 • 71 citations

Recombinant human immunodeficiency virus type‐1 (HIV‐1) Tat protein sequentially up‐regulates IL‐6 and TFG‐β1 mRNA expression and protein synthesis in peripheral blood monocytes

1994 • 70 citations

Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis.

1998 • 66 citations

American cutaneous and mucocutaneous leishmaniasis.

1987 • 59 citations

Immune deficiency in chronic Trypanosoma cruzi infection. Recombinant IL-1 restores Th function for antibody production.

1989 • 46 citations

Oral Delivery of Group A Streptococcal Cell Walls Augments Circulating TGF-β and Suppresses Streptococcal Cell Wall Arthritis

1998 • 44 citations

Histological features predictive of liver fibrosis in chronic hepatitis C infection.

1996 • 43 citations

Response to stimulation with recombinant cytokines and synthesis of cytokines by murine intestinal macrophages infected with the Mycobacterium avium complex

1995 • 41 citations

HIV-1 gp160 Induces Transforming Growth Factor-β Production in Human PBMC

1996 • 39 citations

An in vitro model for infection with Leishmania major that mimics the immune response in mice

1997 • 38 citations

Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression.

1994 • 36 citations

Spleen cell-mediated suppression of IgG production to a non-parasite antigen during chronic Trypanosoma cruzi infection in mice.

1983 • 35 citations

Transforming growth factor beta (TGF-b1) plays a detrimental role in the progression of experimental Mycobacterium avium infection; in vivo and in vitro evidence

1991 • 35 citations

Suppressed antibody responses to sheep erythrocytes in mice with chronic Trypanosoma cruzi infections are restored with interleukin 2.

1984 • 34 citations

Recombinant granulocyte-macrophage colony-stimulating factor restores deficient immune responses in mice with chronic Trypanosoma cruzi infections.

1990 • 31 citations

Experimental oncogene induced prostate cancer.

1991 • 29 citations

Transforming growth factor beta production during rat cytomegalovirus infection.

1997 • 26 citations

TGF-β: upregulator of HIV replication in macrophages

1991 • 26 citations

Secretion of cytokines by human synoviocytes during in vitro infection with Chlamydia trachomatis.

1998 • 24 citations

Neutralization of transforming growth factor beta 1 augments hepatitis C virus-specific cytotoxic T lymphocyte induction in vitro.

1997 • 21 citations

An Immunoaffinity‐Purified Trypanosoma cruzi Antigen Suppresses Cellular Proliferation through a TGF‐β‐Mediated Mechanism

1998 • 21 citations

Contact sensitivity responses in mice infected with Trypanosoma cruzi

1978 • 21 citations

Interleukin-2 suppresses activated macrophage intracellular killing activity by inducing macrophages to secrete TGF-β

1994 • 20 citations

Activation of latent transforming growth factor beta during Chlamydia trachomatis-induced murine pneumonia

1996 • 19 citations

The Replicative Restriction of Lymphocytotropic Isolates of HIV-1 in Macrophages Is Overcome by TGF-β

1992 • 11 citations

The leishmaniases in biology and medicine. Volume II. Clinical aspects and control.

1987 • 10 citations

Inhibition of Human Immunodeficiency Virus Type 1 Multiplication by Transforming Growth Factor β₁and AZT in HIV-1-Infected Myeloid Cells

1995 • 7 citations