A new method for isolating tyrosine kinase substrates used to identify Fish, an SH3 and PX domain-containing protein, and Src substrate

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein modules and signalling networks

1995 • 2,447 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1995 • 1,185 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1997 • 658 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

The biochemical basis of the NADPH oxidase of phagocytes

1993 • 631 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

1994 • 525 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

1995 • 431 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

1994 • 407 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

Recognition and specificity in protein tyrosine kinase-mediated signalling

1995 • 367 citations

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

1996 • 364 citations

A target for Src in mitosis

1994 • 361 citations

Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

1997 • 350 citations

Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak- binding region

1994 • 311 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.

1992 • 309 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3‐kinases: Binding partners of SH3 domains?

1996 • 304 citations

Cooperative interaction of S. pombe proteins required for mating and morphogenesis

1994 • 303 citations

Src family protein tyrosine kinases and cellular signal transduction pathways

1995 • 298 citations

p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains

1993 • 295 citations

Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.

1994 • 283 citations

Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis.

1990 • 280 citations

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.

1992 • 271 citations

pp60c-src activation in human colon carcinoma.

1989 • 267 citations

p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo.

1992 • 266 citations

The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.

1996 • 265 citations

The 2.35 å crystal structure of the inactivated form of chicken src: a dynamic molecule with multiple regulatory interactions

1997 • 251 citations

Presence of an SH2 Domain in the Actin-Binding Protein Tensin

1991 • 248 citations

PTB Domain Binding to Signaling Proteins Through a Sequence Motif Containing Phosphotyrosine

1995 • 245 citations

Ras-related GTPases and the cytoskeleton.

1992 • 232 citations

Cloning of ligand targets: Systematic isolation of SH3 domain-containing proteins

1996 • 224 citations

The Src family of tyrosine protein kinases in hemopoietic signal transduction

1992 • 221 citations

A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains

1992 • 219 citations

A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton

1997 • 214 citations

Pheromone Response in Yeast: Association of Bem1p with Proteins of the MAP Kinase Cascade and Actin

1995 • 209 citations

A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappa B signalling pathways

1998 • 208 citations

Structure‐function relationships in Src family and related protein tyrosine kinases

1995 • 201 citations

Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast.

1994 • 199 citations

The complex of polyoma virus middle-T antigen and pp60c-src.

1984 • 196 citations

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins.

1996 • 176 citations

Transit of pp60v-src to the plasma membrane.

1982 • 165 citations

PairWise and SearchWise: Finding the Optimal Alignment in a Simultaneous Comparison of a Protein Profile against All DNA Translation Frames

1996 • 164 citations

Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions.

1995 • 163 citations

Extending the C2 domain family: C2s in PKCs δ, ϵ,η,θ, phospholipases, GAPs, and perforin

1996 • 158 citations

Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA

1997 • 155 citations

Mouse p170 Is a Novel Phosphatidylinositol 3-Kinase Containing a C2 Domain

1996 • 154 citations

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

1995 • 137 citations

Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate.

1993 • 125 citations

Stable association of pp60^src and pp59^fyn with the focal adhesion-associated protein tyrosine kinase, pp125^FAK

1994 • 119 citations

Identification and Characterization of a Novel Cytoskeleton-Associated pp60^src Substrate

1991 • 113 citations

Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn.

1995 • 111 citations

The Rac Target NADPH Oxidase p67 Interacts Preferentially with Rac2 Rather Than Rac1

1996 • 110 citations

Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein.

1992 • 94 citations

The Saccharomyces cerevisiae MVP1 Gene Interacts with VPS1 and Is Required for Vacuolar Protein Sorting

1995 • 77 citations

Cpk Is a Novel Class of Drosophila PtdIns 3-Kinase Containing a C2 Domain

1996 • 65 citations

Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. II. VAM7, a gene for regulating morphogenic assembly of the vacuoles.

1992 • 53 citations

The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases.

1993 • 50 citations

Molecular-Cloning of cDNA Encoding Human Drebrin E and Chromosomal Mapping of Its Gene

1993 • 34 citations

Examining the Specificity of Src Homology 3 Domain–Ligand Interactions with Alkaline Phosphatase Fusion Proteins

1997 • 33 citations

Identification and Sequence Analysis of cDNAs Encoding a 110-Kilodalton Actin Filament-Associated pp60^src Substrate

1993 • 30 citations

Genetic mapping and embryonic expression of a novel, maternally transcribed gene Mem3

1996 • 23 citations

Molecular Cloning of a Novel Rat Salt-Tolerant Protein by Functional Complementation in Yeast

1996 • 3 citations