Signal transduction and the Ets family of transcription factors

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 1,870 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

Acetylation: a regulatory modification to rival phosphorylation?

2000 • 1,136 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

The Ets family of transcription factors

1993 • 848 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Regulation of E2F1 activity by acetylation

2000 • 654 citations

Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

1998 • 639 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

1994 • 542 citations

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

1990 • 507 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

Ets transcription factors: nuclear effectors of the Ras–MAP-kinase signaling pathway

1998 • 504 citations

The Ca2+–calmodulin-dependent protein kinase cascade

1999 • 502 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

POU domain family values: flexibility, partnerships, and developmental codes.

1997 • 481 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

CBP: A Signal-Regulated Transcriptional Coactivator Controlled by Nuclear Calcium and CaM Kinase IV

1998 • 420 citations

The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

1991 • 380 citations

Journey to the surface of the cell: Fos regulation and the SRE.

1995 • 376 citations

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

1998 • 369 citations

An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.

1991 • 352 citations

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK

1994 • 350 citations

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

1992 • 343 citations

eFGF regulates Xbra expression during Xenopus gastrulation.

1994 • 340 citations

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1996 • 338 citations

The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells

1993 • 330 citations

Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway

1995 • 327 citations

Ras-Mediated Phosphorylation of a Conserved Threonine Residue Enhances the Transactivation Activities of c-Ets1 and c-Ets2

1996 • 325 citations

Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.

1994 • 323 citations

The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

1994 • 315 citations

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1

1998 • 302 citations

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors

1998 • 296 citations

Signal-specific co-activator domain requirements for Pit-1 activation

1998 • 284 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif

1998 • 265 citations

Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

1992 • 258 citations

Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).

1995 • 255 citations

PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene

2000 • 244 citations

Id proteins control growth induction in mammalian cells.

1994 • 229 citations

Convergence of MAP kinase pathways on the ternary complex factor Sap-1a

1997 • 226 citations

Net, a new ets transcription factor that is activated by Ras.

1994 • 216 citations

Calcium Activates Serum Response Factor-Dependent Transcription By A Ras- and Elk-1-Independent Mechanism That Involves a Ca²⁺/Calmodulin-Dependent Kinase

1995 • 215 citations

Activin-mediated mesoderm induction requires FGF

1994 • 208 citations

Involvement of p21ras in Xenopus mesoderm induction

1992 • 207 citations

A Role for CREB Binding Protein and p300 Transcriptional Coactivators in Ets-1 Transactivation Functions

1998 • 202 citations

Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes

2000 • 201 citations

Regulatory Cascades Involving Calmodulin-Dependent Protein Kinases

2000 • 200 citations

Regulation of Activating Transcription Factor-1 and the cAMP Response Element-binding Protein by Ca2+/Calmodulin-dependent Protein Kinases Type I, II, and IV

1996 • 195 citations

Myeloid Development Is Selectively Disrupted in PU.1 Null Mice

1998 • 191 citations

Activation of ternary complex factor Elk-1 by stress-activated protein kinases

1995 • 190 citations

Transformation suppressor activity of a Jun transcription factor lacking its activation domain

1991 • 190 citations

Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import.

1996 • 173 citations

EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm

1996 • 170 citations

Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.

1994 • 167 citations

Role of PU.1 in Hematopoiesis

1998 • 159 citations

Calcineurin: Not Just a Simple Protein Phosphatase

1997 • 159 citations

Involvement of STAT-1 and Ets Family Members in Interferon-γ Induction of CD40 Transcription in Microglia/Macrophages

2000 • 157 citations

Concerted regulation of protein phosphorylation and dephosphorylation by calmodulin

1991 • 155 citations

Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development

1995 • 155 citations

Studies of acetylation and deacetylation in high mobility group proteins. Identification of the sites of acetylation in HMG-1.

1979 • 154 citations

c-fos transcriptional activation and repression correlate temporally with the phosphorylation status of TCF.

1993 • 153 citations

Id helix–loop–helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors

1999 • 152 citations

Nuclear targets for transcription regulation by oncogenes

1991 • 147 citations

Mitogenic Signaling By Colony-Stimulating Factor 1 and ras Is Suppressed by the ets-2 DNA-Binding Domain and Restored by myc Overexpression

1992 • 147 citations

Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation

1999 • 146 citations

Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1.

1990 • 146 citations

The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1.

1994 • 145 citations

Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition

2000 • 143 citations

The key role of PU.1/SPI-1 in B cells, myeloid cells and macrophages

1999 • 141 citations

Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways.

1995 • 140 citations

Combinatorial interactions between AP-1 and ets domain proteins contribute to the developmental regulation of the macrophage scavenger receptor gene.

1994 • 140 citations

p300/cAMP-responsive Element-binding Protein Interactions with Ets-1 and Ets-2 in the Transcriptional Activation of the Human Stromelysin Promoter

1999 • 133 citations

Real‐time DNA binding measurements of the ETSl recombinant oncoproteins reveal significant kinetic differences between the p42 and p51 isoforms

1994 • 129 citations

Auto-Inhibition of Ets-1 Is Counteracted by DNA Binding Cooperativity with Core-Binding Factor α2

2000 • 128 citations

Ras-responsive genes and tumor metastasis.

1993 • 127 citations

Calcium/Calmodulin-Dependent Protein Kinase Types II and IV Differentially Regulate CREB-Dependent Gene Expression

1994 • 123 citations

Requirements for Calcium and Calmodulin in the Calmodulin Kinase Activation Cascade

1996 • 122 citations

ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.

1994 • 121 citations

The Zinc Finger Transcription Factor Egr-1 Potentiates Macrophage Differentiation of Hematopoietic Cells

1995 • 120 citations

JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye

1995 • 118 citations

Regulation of the Human TNF Promoter by the Transcription Factor Ets

1995 • 116 citations

Functional Interaction of c-Ets-1 and GHF-1/Pit-1 Mediates Ras Activation of Pituitary-Specific Gene Expression: Mapping of the Essential c-Ets-1 Domain

1995 • 116 citations

Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias

1997 • 115 citations

Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors.

1994 • 113 citations

Signal Transduction by Tumor Necrosis Factor Mediated by JNK Protein Kinases

1994 • 110 citations

Signal integration at the c-fos promoter

1995 • 109 citations

The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalation

1995 • 108 citations

Stimulation of Elk1 Transcriptional Activity by Mitogen-activated Protein Kinases Is Negatively Regulated by Protein Phosphatase 2B (Calcineurin)

1999 • 105 citations

Protein serine/threonine phosphatases

1996 • 105 citations

Fli-1, an Ets-Related Transcription Factor, Regulates Erythropoietin-Induced Erythroid Proliferation and Differentiation: Evidence for Direct Transcriptional Repression of the Rb Gene during Differentiation

1999 • 104 citations

Synergistic Regulation of the Human Interleukin-12 p40 Promoter by NFκB and Ets Transcription Factors in Epstein-Barr Virus-transformed B Cells and Macrophages

1998 • 103 citations

Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2

1997 • 102 citations

The Ets2 Transcription Factor Inhibits Apoptosis Induced by Colony-Stimulating Factor 1 Deprivation of Macrophages through a Bcl-x_L-Dependent Mechanism

1999 • 100 citations

Regulation of the Human Interleukin-5 Promoter by Ets Transcription Factors

1999 • 100 citations

Control of midline glia development in the embryonic Drosophila CNS

1997 • 99 citations

Role of the Ets Transcription Factors in the Regulation of the Vascular-Specific Tie2 Gene

1999 • 98 citations

Calcium-induced phosphorylation of ETS1 inhibits its specific DNA binding activity.

1994 • 95 citations

Ternary complex formation over the c-fos serum response element: p62TCF exhibits dual component specificity with contacts to DNA and an extended structure in the DNA-binding domain of p67SRF.

1992 • 94 citations

NF-IL6 (C/EBPβ) Vigorously Activates il1b Gene Expression via a Spi-1 (PU.1) Protein-Protein Tether

2000 • 92 citations

Overexpression of PU.1 Induces Growth and Differentiation Inhibition and Apoptotic Cell Death in Murine Erythroleukemia Cells

1997 • 90 citations

Inhibitory Cross-talk by cAMP Kinase on the Calmodulin-dependent Protein Kinase Cascade

1997 • 90 citations

PU.1 and the Granulocyte- and Macrophage Colony-Stimulating Factor Receptors Play Distinct Roles in Late-Stage Myeloid Cell Differentiation

1999 • 89 citations

Regulation of Rat Cytochrome P450C24 (CYP24) Gene Expression

2000 • 89 citations

Cooperation Among Stat1, Glucocorticoid Receptor, and PU.1 in Transcriptional Activation of the High-Affinity Fcγ Receptor I in Monocytes

2000 • 85 citations

Oncoprotein-Mediated Signalling Cascade Stimulates c-Jun Activity by Phosphorylation of Serines 63 and 73

1992 • 83 citations

The role of yan in mediating the choice between cell division and differentiation

1995 • 80 citations

A Two-Step Mechanism for Recruitment of Pip by PU.1

1998 • 77 citations

Insights derived from the structures of the Ser/Thr phosphatases calcineurin and protein phosphatase 1

1995 • 72 citations

IgM receptor-mediated transactivation of the IgH 3′ enhancer couples a novel Elf-1-AP-1 protein complex to the developmental control of enhancer function.

1995 • 69 citations

Analysis of the Bruton's tyrosine kinase gene promoter reveals critical PU.1 and SP1 sites

1996 • 69 citations

Raf and Fibroblast Growth Factor Phosphorylate Elk1 and Activate the Serum Response Element of the Immediate Early Genepip92 by Mitogen-Activated Protein Kinase-Independent as Well as -Dependent Signaling Pathways

1998 • 68 citations

Calcium/Calmodulin-Dependent Protein Kinase Kinase: Identification of Regulatory Domains

1997 • 67 citations

GHF-1/Pit-1 Functions as a Cell-specific Integrator of Ras Signaling by Targeting the Ras Pathway to a Composite Ets-1/GHF-1 Response Element

1996 • 65 citations

ATF and Jun transcription factors, acting through an Ets / CRE promoter module, mediate lipopolysaccharide inducibility of the chemokine RANTES in monocytic Mono Mac 6 cells

2000 • 65 citations

A Role for the Mitogen-Activated Protein Kinase in Mediating the Ability of Thyrotropin-Releasing Hormone to Stimulate the Prolactin Promoter

1999 • 63 citations

The Net Repressor Is Regulated by Nuclear Export in Response to Anisomycin, UV, and Heat Shock

1999 • 62 citations

The Transcription Factors Elk-1 and Serum Response Factor Interact by Direct Protein-Protein Contacts Mediated by a Short Region of Elk-1

1994 • 57 citations

The Pit-1 Homeodomain and β-Domain Interact with Ets-1 and Modulate Synergistic Activation of the Rat Prolactin Promoter

2000 • 55 citations

Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators.

1990 • 53 citations

IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells

2000 • 51 citations

Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-β type II receptor expression and restores the TGF-β signaling pathway in Hs578t human breast cancer cells

2000 • 49 citations

The p42 variant of ETS1 protein rescues defective Fas-induced apoptosis in colon carcinoma cells

1999 • 48 citations

Prolactin-releasing Peptide Activation of the Prolactin Promoter Is Differentially Mediated by Extracellular Signal-regulated Protein Kinase and c-Jun N-terminal Protein Kinase

2000 • 46 citations

Non-nuclear oncogenes and the regulation of gene expression in transformed cells.

1993 • 42 citations

Elf-1 Contributes to the Function of the Complex Interleukin (IL)-2–responsive Enhancer in the Mouse IL-2 Receptor α Gene

1997 • 41 citations

Elf-1 Regulates Basal Expression from the T Cell Antigen Receptor ζ-Chain Gene Promoter

1998 • 41 citations

Granulocyte Colony-stimulating Factor Induces egr-1Up-regulation through Interaction of Serum Response Element-binding Proteins

2000 • 40 citations

Role of ETS1 in IL-2 gene expression.

1995 • 40 citations

The Spemann organizer-expressed zinc finger gene Xegr-1 responds to the MAP kinase/Ets-SRF signal transduction pathway

1998 • 40 citations

ERP, a New Member of the ets Transcription Factor/Oncoprotein Family: Cloning, Characterization, and Differential Expression during B-Lymphocyte Development

1994 • 37 citations

Combinatorial Interactions between AP-1 and ets Domain Proteins Contribute to the Developmental Regulation of the Macrophage Scavenger Receptor Gene

1994 • 37 citations

Activation of the p21Waf1/Cip1Promoter by theetsOncogene Family Transcription Factor E1AF

1997 • 36 citations

ets-1 in Astrocytes: Expression and Transmitter-Evoked Phosphorylation

1995 • 31 citations

A Potential Role for Elf-1 in CD4 Promoter Function

1999 • 31 citations

ets-2 Regulates cdc2 Kinase Activity in Mammalian Cells: Coordinated Expression of cdc2 and Cyclin A

1995 • 28 citations

Net-b, a Ras-Insensitive Factor That Forms Ternary Complexes with Serum Response Factor on the Serum Response Element of the fos Promoter

1997 • 27 citations

Dopamine Inhibits TRH-Induced MAP Kinase Activation in Dispersed Rat Anterior Pituitary Cells

1994 • 27 citations

The mechanism of complex formation between Fli-1 and SRF transcription factors

2000 • 26 citations

Activation of the c-fos SRE through SAP-1a

1997 • 17 citations

Anti-immunoglobulin M activates nuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes.

1995 • 15 citations

The ets Family of Genes: Molecular Biology and Functional Implications

1989 • 15 citations

View Factor Between Inclined Rectangles

1997 • 13 citations

Elf-1 and Stat5 Bind to a Critical Element in a New Enhancer of the Human Interleukin-2 Receptor α Gene

1997 • 7 citations