Oncogenic Ki-ras but Not Oncogenic Ha-rasBlocks Integrin β1-Chain Maturation in Colon Epithelial Cells

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

β1-6 Branching of Asn-Linked Oligosaccharides Is Directly Associated with Metastasis

1987 • 929 citations

Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits.

1987 • 727 citations

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

1989 • 672 citations

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1988 • 620 citations

Integrin Activation by R-ras

1996 • 414 citations

Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V.

1995 • 266 citations

Mutations in N-ras predominate in acute myeloid leukemia

1987 • 239 citations

Signalling pathways: Jack of all cascades

1996 • 186 citations

Functional role of N-glycosylation in alpha 5 beta 1 integrin receptor. De-N-glycosylation induces dissociation or altered association of alpha 5 and beta 1 subunits and concomitant loss of fibronectin binding activity.

1994 • 183 citations

Steps in the morphogenesis of a polarized epithelium: II. disassembly and assembly of plasma membrane domains during reversal of epithelial cell polarity in multicellular epithelial (MDCK) cysts

1990 • 182 citations

Apical, basal, and lateral cues for epithelial polarization

1995 • 181 citations

Review of Chromosome Studies in Urological Tumors. II. Cytogenetics and Molecular Genetics of Bladder Cancer

1994 • 171 citations

Expression of VLA-alpha 2, VLA-alpha 6, and VLA-beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases.

1991 • 166 citations

Low expression of collagen receptors in moderate and poorly differentiated colorectal adenocarcinomas

1990 • 160 citations

Analysis of the role of glycosylation of the human fibronectin receptor

1989 • 154 citations

Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells.

1994 • 151 citations

Genetic Heterogeneity of the c-K-ras Locus in Colorectal Adenomas but not in Adenocarcinomas

1993 • 136 citations

Regulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation.

1995 • 134 citations

Integrin expression and localization in normal MDCK cells and transformed MDCK cells lacking apical polarity

1994 • 121 citations

Epidermal Growth Factor Regulates the Exchange Rate of Guanine Nucleotides on p21^ras in Fibroblasts

1993 • 117 citations

Regulation of epithelial cell surface polarity reversal by β1 integrins

1994 • 115 citations

Determination of Tumor Aggressiveness in Colorectal Cancer by K-ras-2 Analysis

1993 • 107 citations

The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly.

1994 • 97 citations

Oncogenes conferring metastatic potential induce increased branching of Asn-linked oligosaccharides in rat2 fibroblasts.

1989 • 96 citations

Transcriptional and post-translational regulation of beta 1 integrin expression during keratinocyte terminal differentiation.

1992 • 92 citations

Multilayering and loss of apical polarity in MDCK cells transformed with viral K-ras.

1991 • 92 citations

Transforming growth factor beta 1 acts as an autocrine-negative growth regulator in colon enterocytic differentiation but not in goblet cell maturation.

1990 • 91 citations

Enzymatic amplification involving glycosyltransferases forms the basis for the increased size of asparagine-linked glycans at the surface of NIH 3T3 cells expressing the N-ras proto-oncogene.

1991 • 88 citations

K‐ras point mutations in human colorectal carcinomas: Relation to aneuploidy and metastasis

1992 • 77 citations

Map Kinases Erk1 And Erk2: Pleiotropic Enzymes In A Ubiquitous Signaling Network

1994 • 74 citations

Antisense Oligonucleotides Demonstrate a Dominant Role of c-Ki-RAS Proteins in Regulating the Proliferation of Diploid Human Fibroblasts

1996 • 73 citations

Alteration of expression in integrin β1-subunit correlates with invasion and metastasis in colorectal cancer

1995 • 60 citations

The c-K-ras gene and human cancer (review).

1987 • 55 citations

Frequency of H-rasmutations in human bladder cancer detected by direct sequencing

1994 • 55 citations

Signal transduction through extracellular signal-regulated kinase-like pp57 blocked in differentiated cells having low protein kinase C beta activity.

1993 • 45 citations

Transfection of N-Acetylglucosaminyltransferase III Gene Suppresses Expression of Hepatitis B Virus in a Human Hepatoma Cell Line, HB611

1995 • 43 citations

Two roles for transforming growth factor beta 1 in colon enterocytic cell differentiation.

1992 • 42 citations

Transforming growth factor beta 1 (TGF-beta 1) inhibits retinoblastoma gene expression but not pRB phosphorylation in TGF-beta 1-growth stimulated colon carcinoma cells.

1992 • 40 citations

Overexpression of ras in mucus-secreting human colon carcinoma cells of low tumorigenicity.

1987 • 33 citations

The size of the intracellular β 1-integrin precursor pool regulates maturation of β 1-integrin subunit and associated α-subunits

1994 • 31 citations

The capacity for growth stimulation by TGF beta 1 seen only in advanced colon cancers cannot be ascribed to mutations in APC, DCC, p53 or ras.

1994 • 27 citations

Induction of markers of normal differentiation in human colon carcinoma cells by the v-rasH oncogene.

1993 • 27 citations

Treatment of Bladder Neck Contracture by Plastic Operation

1955 • 19 citations