Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

The Kidney: Physiology and Pathophysiology

1992 • 1,714 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Cyclic nucleotide research — still expanding after half a century

2002 • 869 citations

Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger

1998 • 839 citations

Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies

2002 • 830 citations

Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.

1998 • 799 citations

Nitric Oxide and Cardiac Function

1996 • 721 citations

Mena, a Relative of VASP and Drosophila Enabled, Is Implicated in the Control of Microfilament Dynamics

1996 • 667 citations

Genetic Decreases in Atrial Natriuretic Peptide and Salt-Sensitive Hypertension

1995 • 650 citations

Accelerated Atherosclerosis, Aortic Aneurysm Formation, and Ischemic Heart Disease in Apolipoprotein E/Endothelial Nitric Oxide Synthase Double-Knockout Mice

2001 • 609 citations

Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle

2000 • 599 citations

Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A

1997 • 569 citations

Regulation of Myosin Phosphatase by a Specific Interaction with cGMP- Dependent Protein Kinase Iα

1999 • 514 citations

Defective smooth muscle regulation in cGMP kinase I-deficient mice

1998 • 510 citations

Regulation of Nitric Oxide-Sensitive Guanylyl Cyclase

2003 • 502 citations

Invited Review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression

2001 • 500 citations

Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function

2003 • 499 citations

Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts.

1998 • 496 citations

Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP

1994 • 467 citations

Negative Regulation of Fibroblast Motility by Ena/VASP Proteins

2000 • 460 citations

Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Iβ

2000 • 448 citations

Scientific and therapeutic advances in antiplatelet therapy

2002 • 412 citations

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

1996 • 405 citations

Distinct and specific functions of cGMP-dependent protein kinases

1997 • 394 citations

Molecular mechanism of cGMP-mediated smooth muscle relaxation

2000 • 378 citations

Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice.

1998 • 339 citations

Rising behind NO: cGMP-dependent protein kinases

2000 • 338 citations

Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A

2003 • 335 citations

Taming platelets with cyclic nucleotides11Abbreviations: ABP, actin binding protein; AC, adenylyl cyclase; cAMP, cyclic AMP; cAMP-PK, cAMP-dependent protein kinase; cGMP, cyclic GMP; cGMP-PK, cGMP-dependent protein kinase; DAG, 1,2-diacylglycerol; EDRF, endothelium-derived relaxing factor; GC, guanylyl cyclase; GP, glycoprotein; Hsp27, heat shock protein 27; IP3, inositol 1,4,5- trisphosphate; IRAG, IP3 receptor-associated cGMP-PK substrate; MAPK, mitogen-activated protein kinase; MAPKAPK-2, …

2001 • 323 citations

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

2002 • 316 citations

Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice

2002 • 309 citations

Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A–deficient mice

2001 • 305 citations

Enhanced atherosclerosis and kidney dysfunction in eNOS–/–Apoe–/– mice are ameliorated by enalapril treatment

2000 • 301 citations

NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle

2002 • 300 citations

Nitric Oxide Enhances Angiogenesis via the Synthesis of Vascular Endothelial Growth Factor and cGMP After Stroke in the Rat

2003 • 288 citations

An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice

2000 • 278 citations

Regulation of Gene Expression by Cyclic GMP

2003 • 276 citations

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

2002 • 274 citations

A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy

2001 • 270 citations

A Stimulatory Role for cGMP-Dependent Protein Kinase in Platelet Activation

2003 • 265 citations

Natriuretic peptides: Physiology, therapeutic potential, and risk stratification in ischemic heart disease

1998 • 261 citations

Structure, Regulation, and Function of Mammalian Membrane Guanylyl Cyclase Receptors, With a Focus on Guanylyl Cyclase-A

2003 • 260 citations

Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice

2002 • 250 citations

Cyclic nucleotide analogs as biochemical tools and prospective drugs

2000 • 246 citations

Genetic Deficiency of Inducible Nitric Oxide Synthase Reduces Atherosclerosis and Lowers Plasma Lipid Peroxides in Apolipoprotein E–Knockout Mice

2001 • 242 citations

Mechanisms of NO/cGMP-Dependent Vasorelaxation

2000 • 241 citations

NO, nitrotyrosine, and cyclic GMP in signal transduction.

2001 • 239 citations

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

2003 • 233 citations

Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase I

1999 • 228 citations

Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system

2005 • 226 citations

Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle

1988 • 223 citations

Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells

2002 • 216 citations

Stroke Prevention Therapy Beyond Antithrombotics: Unifying Mechanisms in Ischemic Stroke Pathogenesis and Implications for Therapy

2002 • 213 citations

Actin-based motility: stop and go with Ena/VASP proteins

2001 • 207 citations

Structure and function of cGMP-dependent protein kinases

2005 • 205 citations

Deficiency in Inducible Nitric Oxide Synthase Results in Reduced Atherosclerosis in Apolipoprotein E-Deficient Mice

2000 • 203 citations

Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice

2000 • 194 citations

RhoA Expression Is Controlled by Nitric Oxide through cGMP-dependent Protein Kinase Activation

2003 • 173 citations

Muscarinic and β-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase

1999 • 171 citations

cGMP-Dependent Protein Kinase I Mediates the Negative Inotropic Effect of cGMP in the Murine Myocardium

2002 • 167 citations

Long-term nitrate use may be deleterious in ischemic heart disease: A study using the databases from two large-scale postinfarction studies

1999 • 162 citations

Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration

2003 • 162 citations

Active Rho Kinase (ROK-α) Associates with Insulin Receptor Substrate-1 and Inhibits Insulin Signaling in Vascular Smooth Muscle Cells

2002 • 159 citations

Direct activation of PDE5 by cGMP

2003 • 158 citations

Protein Kinase G Mediates Vascular Endothelial Growth Factor-induced Raf-1 Activation and Proliferation in Human Endothelial Cells

1998 • 156 citations

Cytoskeletal Effects of Rho-Like Small Guanine Nucleotide–Binding Proteins in the Vascular System

2001 • 155 citations

Impairment of LTD and cerebellar learning by Purkinje cell–specific ablation of cGMP-dependent protein kinase I

2003 • 151 citations

Regulation of Gene Expression by cGMP-dependent Protein Kinase

1996 • 146 citations

Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects

1998 • 144 citations

Hypertension Does Not Account for the Accelerated Atherosclerosis and Development of Aneurysms in Male Apolipoprotein E/Endothelial Nitric Oxide Synthase Double Knockout Mice

2001 • 143 citations

Nitric oxide stimulates guanylate cyclase and regulates sodium transport in rabbit proximal tubule

1996 • 142 citations

Differential role of cyclic GMP–dependent protein kinase II in ion transport in murine small intestine and colon

2000 • 138 citations

Antiproliferative action of cyclic GMP-elevating vasodilators in cultured rabbit aortic smooth muscle cells

1989 • 138 citations

Activation of Mitogen-activated Protein Kinase Pathways by Cyclic GMP and Cyclic GMP-dependent Protein Kinase in Contractile Vascular Smooth Muscle Cells

1999 • 138 citations

Gene Transfer of cGMP-Dependent Protein Kinase I Enhances the Antihypertrophic Effects of Nitric Oxide in Cardiomyocytes

2002 • 136 citations

Exacerbated Transplant Arteriosclerosis in Inducible Nitric Oxide–Deficient Mice

1998 • 135 citations

Engineering the mouse genome by site-specific recombination

1999 • 129 citations

Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)–deficient mice

2003 • 129 citations

Lack of Plasminogen Activator Inhibitor-1 Promotes Growth and Abnormal Matrix Remodeling of Advanced Atherosclerotic Plaques in Apolipoprotein E–Deficient Mice

2002 • 125 citations

KT5823 Inhibits cGMP-dependent Protein Kinase Activity in Vitro but Not in Intact Human Platelets and Rat Mesangial Cells

2000 • 124 citations

Regulation of Gene Expression by Cyclic GMP-Dependent Protein Kinase Requires Nuclear Translocation of the Kinase: Identification of a Nuclear Localization Signal

1997 • 121 citations

Heat Shock Protein 27 Is a Substrate of cGMP-dependent Protein Kinase in Intact Human Platelets

2001 • 120 citations

Inotropic response to β‐adrenergic receptor stimulation and anti‐adrenergic effect of ACh in endothelial NO synthase‐deficient mouse hearts

2001 • 120 citations

Cyclic GMP-Dependent Protein Kinase II Plays a Critical Role in C-Type Natriuretic Peptide-Mediated Endochondral Ossification

2002 • 116 citations

Natriuretic Factors and Nitric Oxide Suppress Plasminogen Activator Inhibitor-1 Expression in Vascular Smooth Muscle Cells

1998 • 112 citations

Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy

2001 • 112 citations

Dipyridamole Enhances NO/cGMP-Mediated Vasodilator-Stimulated Phosphoprotein Phosphorylation and Signaling in Human Platelets

2003 • 112 citations

Smooth muscle cell expression of type I cyclic GMP-dependent protein kinase is suppressed by continuous exposure to nitrovasodilators, theophylline, cyclic GMP, and cyclic AMP.

1997 • 111 citations

cGMP-mediated signaling via cGKIα is required for the guidance and connectivity of sensory axons

2002 • 108 citations

Functional Reconstitution of Vascular Smooth Muscle Cells With cGMP-Dependent Protein Kinase I Isoforms

2002 • 106 citations

Decreased Neointimal Thickening After Arterial Wall Injury in Inducible Nitric Oxide Synthase Knockout Mice

1999 • 104 citations

Actin Binding of Human LIM and SH3 Protein Is Regulated by cGMP- and cAMP-dependent Protein Kinase Phosphorylation on Serine 146

2003 • 100 citations

Regulation of the Expression of Cyclic GMP-Dependent Protein Kinase by Cell Density in Vascular Smooth Muscle Cells

1994 • 100 citations

ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells

1998 • 97 citations

Hippocampal cGMP-Dependent Protein Kinase I Supports an Age- and Protein Synthesis-Dependent Component of Long-Term Potentiation But Is Not Essential for Spatial Reference and Contextual Memory

2003 • 94 citations

Role of nitric oxide in the control of renin secretion

1998 • 92 citations

Role of cGMP-kinase II in the control of renin secretion and renin expression.

1998 • 92 citations

Functional characteristics of urinary tract smooth muscles in mice lacking cGMP protein kinase type I

2000 • 92 citations

Physiological concentration of atrial natriuretic peptide induces endothelial regeneration in vitro

2003 • 90 citations

cGMP-dependent Protein Kinase Inhibits Serum-response Element-dependent Transcription by Inhibiting Rho Activation and Functions

2002 • 88 citations

Paradoxical Reduction of Fatty Streak Formation in Mice Lacking Endothelial Nitric Oxide Synthase

2002 • 86 citations

cGMP-Dependent Protein Kinase II Modulates mPer1 and mPer2 Gene Induction and Influences Phase Shifts of the Circadian Clock

2003 • 85 citations

Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression.

1996 • 83 citations

A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells

2003 • 83 citations

Cyclic GMP Regulation of the Plasma Membrane (Ca2+-Mg2+)ATPase in Vascular Smooth Muscle1

1987 • 81 citations

Does Nitric Oxide Regulate Smooth Muscle Cell Proliferation?

1998 • 81 citations

The Molecular Basis of Hypertension

1999 • 81 citations

Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia

1993 • 78 citations

Nitric oxide selectively amplifies FGF-2-induced mitogenesis in primary rat aortic smooth muscle cells

1994 • 77 citations

Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells

1998 • 76 citations

Guanylin peptides: renal actions mediated by cyclic GMP

2000 • 74 citations

Guanylin, Uroguanylin, and Heat-stable Euterotoxin Activate Guanylate Cyclase C and/or a Pertussis Toxin-sensitive G Protein in Human Proximal Tubule Cells

2002 • 73 citations

Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression

2005 • 73 citations

Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase

2003 • 71 citations

Cyclic GMP–Dependent Protein Kinase Expression in Coronary Arterial Smooth Muscle in Response to Balloon Catheter Injury

2000 • 69 citations

Cyclic AMP- and Cyclic GMP-dependent Protein Kinases Differ in Their Regulation of Cyclic AMP Response Element-dependent Gene Transcription

1999 • 68 citations

Overexpression of a Constitutively Active Protein Kinase G Mutant Reduces Neointima Formation and In-Stent Restenosis

2002 • 67 citations

Renal function in NHE3-deficient mice with transgenic rescue of small intestinal absorptive defect

2003 • 66 citations

Distinct localization and function of1,4,5IP3 receptor subtypes and the1,3,4,5IP4 receptor GAP1IP4BP in highly purified human platelet membranes

2000 • 65 citations

cGMP-dependent Protein Kinase Iβ Physically and Functionally Interacts with the Transcriptional Regulator TFII-I

2002 • 64 citations

Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP‐dependent protein kinase I

2000 • 62 citations

The Effect of Nitric Oxide on Fetal Pulmonary Artery Smooth Muscle Growth

1995 • 60 citations

(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the β1-adrenoceptor

2003 • 55 citations

Regulation of apical membrane Na⁺/H⁺exchangers NHE2 and NHE3 in intestinal epithelial cell line C2/bbe

1998 • 54 citations

When reverse genetics meets physiology: the use of site‐specific recombinases in mice

2002 • 54 citations

Distinct localization and function of1,4,5IP3 receptor subtypes and the1,3,4,5IP4 receptor GAP1IP4BP in highly purified human platelet membranes

2000 • 54 citations

Functional Analysis of Type 1α cGMP-dependent Protein Kinase Using Green Fluorescent Fusion Proteins

2001 • 52 citations

Association of phospholamban with a cGMP kinase signaling complex

2003 • 52 citations

Site-specific Phosphorylation and Point Mutations of Telokin Modulate Its Ca2+-desensitizing Effect in Smooth Muscle

2001 • 52 citations

[Ca²⁺]_ihomeostasis and cyclic nucleotide relaxation in aorta of phospholamban-deficient mice

1999 • 51 citations

Estrogen-Induced Vasoprotection Is Independent of Inducible Nitric Oxide Synthase Expression

2001 • 50 citations

Atrial natriuretic peptide-stimulated Ca ²⁺ reabsorption in rabbit kidney requires membrane-targeted, cGMP-dependent protein kinase type II

1999 • 49 citations

A genetic model defines the importance of the atrial natriuretic peptide receptor (guanylyl cyclase-A) in the regulation of kidney function

2000 • 38 citations

cGMP-dependent protein kinase is present in high concentrations in contractile cells of the kidney vasculature.

1986 • 38 citations

Phosphorylation of smg p21B/rap1B p21 by cyclic GMP‐dependent protein kinase

1992 • 34 citations

3-D MRI assessment of regional left ventricular systolic wall stress in patients with reperfused MI

2003 • 31 citations

Expression of cGMP‐dependent protein kinase I and its substrate VASP in neointimal cells of the injured rat carotid artery

1998 • 26 citations

Mouse Models of NO/Natriuretic Peptide/cGMP Kinase Signaling

2004 • 18 citations

[Atrial natriuretic hormone].

1987 • 17 citations

Renal proximal tubule function is preserved in Cftr^tm2camΔF508 cystic fibrosis mice

2001 • 15 citations

INCREASED BLOOD PRESSURE AND LOSS OF ANP-INDUCED NATRIURESIS IN MICE LACKING DARPP-32 GENE

2001 • 15 citations

Inhibition of platelet P2Y12 and α2A receptor signaling by cGMP-dependent protein kinase

2002 • 12 citations

Cloning of a chick A 3 adenosine receptor: characterization of ligand binding and receptor-effector coupling of chick A 1 and A 3 adenosine receptors

2001 • 11 citations

NO-, but not ACh-induced arteriolar dilations are impaired in cGMP-dependent protein kinase deficient mice

2003 • 1 citations

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