Genetic Deficiency of Inducible Nitric Oxide Synthase Reduces Atherosclerosis and Lowers Plasma Lipid Peroxides in Apolipoprotein E–Knockout Mice

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 897 citations

Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages

1980 • 851 citations

Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct.

1987 • 817 citations

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

1997 • 680 citations

Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.

1995 • 585 citations

Nitric oxide and oxygen radicals: a question of balance

1995 • 568 citations

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

1994 • 498 citations

The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.

1981 • 468 citations

Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels

1997 • 468 citations

Inducible Nitric-oxide Synthase Generates Superoxide from the Reductase Domain

1998 • 389 citations

Enhanced atherosclerosis and kidney dysfunction in eNOS–/–Apoe–/– mice are ameliorated by enalapril treatment

2000 • 301 citations

Peroxynitrite modification of low‐density lipoprotein leads to recognition by the macrophage scavenger receptor

1993 • 279 citations

Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production

1995 • 251 citations

Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis.

1997 • 247 citations

Nitric Oxide (NO) Donor Molecules

1995 • 221 citations

Deficiency in Inducible Nitric Oxide Synthase Results in Reduced Atherosclerosis in Apolipoprotein E-Deficient Mice

2000 • 203 citations

<scp>l</scp> -Arginine Prevents Xanthoma Development and Inhibits Atherosclerosis in LDL Receptor Knockout Mice

1997 • 159 citations

Modulation of platelet aggregation by an l-arginine-nitric oxide pathway

1991 • 138 citations

Exacerbated Transplant Arteriosclerosis in Inducible Nitric Oxide–Deficient Mice

1998 • 135 citations

Expression of inducible nitric oxide synthase in T lymphocytes and macrophages of cholesterol-fed rabbits

1997 • 92 citations

The Effect of Nitric Oxide Release Rates on the Oxidation of Human Low Density Lipoprotein

1997 • 78 citations

The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro

1993 • 75 citations

Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury.

1993 • 57 citations

NOS2 Mediates Opposing Effects in Models of Acute and Chronic Cardiac Rejection

1998 • 52 citations

Oxidation of LDL to a biologically active form by derivatives of nitric oxide and nitrite in the absence of superoxide. Dependence on pH and oxygen.

1994 • 44 citations

Mouse models of atherosclerosis.

1998 • 34 citations