KT5823 Inhibits cGMP-dependent Protein Kinase Activity in Vitro but Not in Intact Human Platelets and Rat Mesangial Cells

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

[1] Assays of protein kinase

1983 • 832 citations

Defective smooth muscle regulation in cGMP kinase I-deficient mice

1998 • 510 citations

Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP

1994 • 467 citations

cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.

1994 • 451 citations

Distinct and specific functions of cGMP-dependent protein kinases

1997 • 394 citations

Pharmacology of Protein Kinase Inhibitors

1992 • 367 citations

The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function

1999 • 347 citations

Analysis and Regulation of Vasodilator-stimulated Phosphoprotein Serine 239 Phosphorylation in Vitro and in Intact Cells Using a Phosphospecific Monoclonal Antibody

1998 • 333 citations

Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture

1980 • 306 citations

The graphical determination of Km and Ki

1972 • 290 citations

Glomerular cells in culture

1983 • 237 citations

Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase I

1999 • 228 citations

Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system

2005 • 226 citations

Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice

1999 • 221 citations

Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase

1995 • 218 citations

Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor

1996 • 213 citations

cGMP-Elevating Agents Suppress Proliferation of Vascular Smooth Muscle Cells by Inhibiting the Activation of Epidermal Growth Factor Signaling Pathway

1997 • 208 citations

Cyclic GMP-dependent Protein Kinase Activates Cloned BKCa Channels Expressed in Mammalian Cells by Direct Phosphorylation at Serine 1072

1999 • 207 citations

Structure and function of cGMP-dependent protein kinases

2005 • 205 citations

The Large Conductance, Voltage-dependent, and Calcium-sensitive K+ Channel, Hslo, Is a Target of cGMP-dependent Protein Kinase Phosphorylation in Vivo

1998 • 174 citations

Concentration and regulation of cyclic nucleotides, cyclic‐nucleotide‐dependent protein kinases and one of their major substrates in human platelets

1992 • 168 citations

Adenovirus-mediated Gene Transfer of cGMP-dependent Protein Kinase Increases the Sensitivity of Cultured Vascular Smooth Muscle Cells to the Antiproliferative and Pro-apoptotic Effects of Nitric Oxide/cGMP

1998 • 163 citations

(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor

1994 • 156 citations

Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP

1992 • 145 citations

Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects

1998 • 144 citations

The cGMP-dependent protein kinase-gene, protein, and function

1993 • 143 citations

Activation of Mitogen-activated Protein Kinase Pathways by Cyclic GMP and Cyclic GMP-dependent Protein Kinase in Contractile Vascular Smooth Muscle Cells

1999 • 138 citations

Inhibition of cGMP‐dependent protein kinase by (Rp)‐guanosine 3',5'‐monophosphorothioates

1990 • 130 citations

Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator.

1995 • 127 citations

Expression of cGMP-Dependent Protein Kinase I and Phosphorylation of Its Substrate, Vasodilator-Stimulated Phosphoprotein, in Human Endothelial Cells of Different Origin

1995 • 122 citations

Immunological distinction between guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases.

1980 • 121 citations

Soluble guanylyl cyclase: Structure and regulation

2005 • 120 citations

Vimentin is transiently co-localized with and phosphorylated by cyclic GMP-dependent protein kinase in formyl-peptide-stimulated neutrophils.

1991 • 118 citations

Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein.

1986 • 112 citations

Inhibition of cyclic GMP‐dependent protein kinase‐mediated effects by (Rp)‐8‐bromo‐PET‐cyclic GMPS

1995 • 111 citations

Plasmin Is a Potent and Specific Chemoattractant for Human Peripheral Monocytes Acting Via a Cyclic Guanosine Monophosphate–Dependent Pathway

1997 • 107 citations

Regulation of Cloned Cardiac L-type Calcium Channels by cGMP-dependent Protein Kinase

2000 • 102 citations

cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases

1995 • 98 citations

Distinct Role of cAMP and cGMP in the Cell Cycle Control of Vascular Smooth Muscle Cells

1999 • 93 citations

The use of dixon plots to study enzyme inhibition

1972 • 90 citations

Activation of the cystic fibrosis transmembrane conductance regulator by cGMP in the human colonic cancer cell line, Caco-2.

1994 • 84 citations

Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia

1993 • 78 citations

Nitric oxide – cyclic GMP pathway regulates vascular smooth muscle cell phenotypic modulation: implications in vascular diseases

1998 • 70 citations

Activation of p38 Mitogen-activated Protein Kinase by Lipopolysaccharide in Human Neutrophils Requires Nitric Oxide-dependent cGMP Accumulation

1999 • 66 citations

Mechanisms of regulation and functions of guanylyl cyclases

2005 • 64 citations

[16] Peptide inhibitors of CAMP-dependent protein kinase

1988 • 57 citations

Mitogen-Activated Protein Kinase Cascades and the Signaling of Hyperosmotic Stress to Immediate Early Genes

1997 • 48 citations

K+ channels in the basolateral membrane of rat cortical collecting duct are regulated by a cGMP-dependent protein kinase

1995 • 47 citations

Troponin I isoforms and differential effects of acidic pH on soleus and cardiac myofilaments

1995 • 45 citations

Regulation of Sensory Neuron Precursor Proliferation by Cyclic GMP‐Dependent Protein Kinase

1998 • 34 citations

The glomerular mesangium: studies of its developmental origin and markers in vivo and in vitro.

1995 • 29 citations

Interaction of native and oxidized lipoprotein(a) with human mesangial cells and matrix

1996 • 22 citations

A novel cGMP‐regulated K⁺ channel in immortalized human kidney epithelial cells (IHKE‐1)

1999 • 22 citations

The glomerular mesangium: studies of its developmental origin and markers in vivo and in vitro

1995 • 22 citations

The involvement of protein kinase G in stimulation of neutrophil migration by endothelins

1998 • 16 citations

Two Distinct Ca²⁺ Influx Pathways Activated by the Bradykinin B₂ Receptor

1996 • 11 citations

Interferon-gamma increases cytoplasmic motility of alveolar macrophages via nitric oxide-dependent signaling pathways.

1994 • 6 citations