Cyclic nucleotide research — still expanding after half a century

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate

1970 • 3,269 citations

Transcriptional regulation by the phosphorylation-dependent factor CREB

2001 • 2,488 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

1968 • 1,423 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Guanylyl cyclases and signaling by cyclic GMP.

2000 • 1,192 citations

Cyclic Nucleotide-Gated Ion Channels

2002 • 1,116 citations

FRACTIONATION AND CHARACTERIZATION OF A CYCLIC ADENINE RIBONUCLEOTIDE FORMED BY TISSUE PARTICLES

1958 • 1,055 citations

A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor

1989 • 996 citations

Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution.

1975 • 932 citations

Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes

2002 • 843 citations

Cyclic 3′,5′-nucleotide phosphodiesterase

1970 • 824 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 811 citations

Fluorescence ratio imaging of cyclic AMP in single cells

1991 • 686 citations

Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues.

1984 • 676 citations

Regulation and Role of Adenylyl Cyclase Isoforms

2001 • 666 citations

Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering

2001 • 583 citations

The GAF domain: an evolutionary link between diverse phototransducing proteins

1997 • 572 citations

Cyclic 3',5'-Nucleotide Phosphodiesterase

1971 • 531 citations

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

2001 • 493 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 487 citations

THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE

1957 • 486 citations

Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.

1978 • 480 citations

A genetically encoded, fluorescent indicator for cyclic AMP in living cells

1999 • 476 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 469 citations

Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial Memory

2002 • 468 citations

The phosphorylase b to a converting enzyme of rabbit skeletal muscle

1956 • 463 citations

Rapid kinetics of second messenger formation in olfactory transduction

1990 • 438 citations

Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes.

1983 • 428 citations

Protein phosphorylation in the brain

1983 • 428 citations

Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

1986 • 427 citations

Histone Phosphorylation: Stimulation by Adenosine 3′,5′-Monophosphate

1968 • 402 citations

Guanyl Cyclase, an Enzyme Catalyzing the Formation of Guanosine 3',5'-Monophosphate from Guanosine Triphosphate

1969 • 391 citations

Compartmentation of G Protein-Coupled Signaling Pathways in Cardiac Myocytes

2001 • 376 citations

Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.

1978 • 372 citations

Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction.

1989 • 370 citations

Assay of adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate in biological materials by enzymic radioisotopic displacement

1968 • 369 citations

AKAP Mediated Signal Transduction

2002 • 343 citations

Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung.

1986 • 338 citations

Rising behind NO: cGMP-dependent protein kinases

2000 • 338 citations

Isolation of adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate from rat urine

1963 • 335 citations

Mechanism of Activation by Adenosine 3′:5′-Cyclic Monophosphate of a Protein Phosphokinase from Rabbit Reticulocytes

1970 • 283 citations

Resolution of some components of adenylate cyclase necessary for catalytic activity.

1977 • 283 citations

Stimulation of Adenosine 3',5'-Monophosphate Hydrolysis by Guanosine 3',5'-Monophosphate

1971 • 275 citations

Purification and properties of the light-activated cyclic nucleotide phosphodiesterase of rod outer segments

1975 • 271 citations

Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator

2001 • 263 citations

THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE

1956 • 228 citations

THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE

1956 • 218 citations

A cyclic 3′,5′-AMP-stimulated protein kinase from cardiac muscle

1970 • 211 citations

Molecular mechanisms for protein kinase A-mediated modulation of immune function

2002 • 195 citations

Induction of Hepatic Enzymes by Adenosine 3′,5′-Monophosphate in Organ Culture

1969 • 190 citations

Modulation of the Endothelial Nitric-oxide Synthase-Caveolin Interaction in Cardiac Myocytes

1998 • 186 citations

A Simple, Sensitive Protein-binding Assay for Guanosine 3′:5′-Monophosphate

1971 • 176 citations

Induction of Cytolysis of Cultured Lymphoma Cells by Adenosine 3′:5′-Cyclic Monophosphate and the Isolation of Resistant Variants

1973 • 176 citations

Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.

1977 • 175 citations

Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl ⁻ channel activation

1998 • 172 citations

Magnitude of increase in retinal cGMP metabolic flux determined by 18O incorporation into nucleotide alpha-phosphoryls corresponds with intensity of photic stimulation.

1983 • 171 citations

In Vivo Assessment of Local Phosphodiesterase Activity Using Tailored Cyclic Nucleotide–Gated Channels as Camp Sensors

2001 • 163 citations

TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca2+-triggered Membrane Association with Selectivity for Interaction with Phosphatidic Acid

2002 • 158 citations

Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein.

1987 • 157 citations

Role of the Receptor in the Mechanism of Action of Adenosine 3′:5′-Cyclic Monophosphate

1971 • 149 citations

Glucagon-Sensitive Adenyl Cyclase in Plasma Membrane of Hepatic Parenchymal Cells

1969 • 147 citations

Organelle-specific Targeting of Protein Kinase AII (PKAII)

1997 • 145 citations

Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone?

1998 • 139 citations

Functional compartmentation of cyclic AMP and protein kinase in heart.

1981 • 118 citations

The Molecules of Visual Excitation

1987 • 109 citations

Measurement of Guanosine 3‘,5‘-Monophosphate and Other Cyclic Nucleotides

1966 • 108 citations

Somatic genetic analysis of cyclic AMP action: Characterization of unresponsive mutants

1975 • 96 citations

Positive Inotropic Agents

1984 • 95 citations

Identification of endogenous substrate proteins for cAMP-dependent protein kinase in bovine brain.

1980 • 90 citations

Light-induced increases in cGMP metabolic flux correspond with electrical responses of photoreceptors.

1986 • 89 citations

Effects of Glyceryl Trinitrate on Endothelium-Dependent and -Independent Relaxation and Cyclic GMP Levels in Rat Aorta and Human Coronary Artery

1987 • 83 citations

Adenosine-3': 5'-phosphoric Acid: A Proof of Structure¹

1959 • 78 citations

THE FORMATION OF A CYCLIC DIANHYDRODIADENYLIC ACID (I) BY THE ALKALINE DEGRADATION OF ADENOSINE-5'-TRIPHOSPHORIC ACID (II)¹

1957 • 72 citations

Simultaneous measurements of intracellular cAMP and L‐type Ca²⁺ current in single frog ventricular myocytes

2001 • 67 citations

High-Affinity Binding and Localization of the Cyclic GMP-Dependent Protein Kinase with the Intermediate Filament Protein Vimentin

1994 • 63 citations

The measurement of cyclic nucleotides by radioimmunoassay.

1970 • 51 citations

Cyclic AMP and cell function

1971 • 36 citations

Hormonal regulation of lipase, phosphorylase, and glycogen synthase in adipose tissue.

1975 • 35 citations

18O labeling of adenine nucleotide alpha-phosphoryls in platelets. Contribution by phosphodiesterase-catalyzed hydrolysis of cAMP.

1983 • 32 citations

The fate of 18O in guanosine monophosphate during enzymic transformations leading to guanosine 3‘,5‘-monophosphate generation.

1981 • 17 citations

[Properties of the adenyl cyclase systems in liver and adipose cells: the mode of action of hormones].

1970 • 14 citations

Imaging of cAMP signals and A-kinase translocation in single living cells.

1993 • 13 citations

Analysis of cyclic AMP and cyclic GMP by enzymic cycling procedures.

1972 • 10 citations

Proceedings: Stimulation of adenylate cyclase from avian erythrocyte membranes by GTP analogs. Separation and partial purification of a GTP-binding protein.

1974 • 3 citations

Cyclic AMP metabolism in intact platelets determined by 18O incorporation into adenine nucleotide alpha-phosphoryls.

1984 • 3 citations

Getting the Message Across

1990 • 2 citations

Deleted Work

1955 • 0 citations